Medicinal composition for treating acute cerebral ischemic stroke

A technology of ischemic stroke and composition, applied in the field of medicine, can solve the problems of narrow time window of thrombolysis, lack of rapid thrombolytic effect of traditional Chinese medicine and single drug, etc.

Inactive Publication Date: 2018-02-02
张惊宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Due to the many contraindications of the above-mentioned thrombolytic drugs, and the narrow time window for thrombolysis, traditional Chinese medicine and single drugs lack rapid thrombolytic effect

Method used

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  • Medicinal composition for treating acute cerebral ischemic stroke
  • Medicinal composition for treating acute cerebral ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0039] Prescription: batroxobin 3500 mg, citicoline 1000 mg, ginkgolide B 600 mg, protoporphyrin sodium 60 mg.

[0040] Preparation:

[0041] 1) Take the prescribed amount of citicoline and sodium protoporphyrin, mix them, add sterile water for injection and dissolve to obtain solution A, and the concentration of the solution is 5 mg / ml based on citicoline;

[0042] 2) Take the prescribed amount of batroxobin, add sterile water for injection, 35,000 mg of phosphoric acid, 105,000 mg of L-arginine, 14,000 mg of mannitol, and 350 mg of Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain a solution B, the concentration of the solution is calculated as 2mg / ml with batroxobin;

[0043] 3) Mix solution A and solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml steriliz...

Embodiment 2

[0044] Example 2 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0045] Prescription: batroxobin 4000mg, citicoline 1500mg, ginkgolide B 900mg, protoporphyrin sodium 62 mg.

[0046] Preparation:

[0047] 1) Take the prescribed amount of citicoline and sodium protoporphyrin, mix them, add sterile water for injection and dissolve to obtain solution A, and the concentration of the solution is 5 mg / ml based on citicoline;

[0048] 2) Take the prescribed amount of batroxobin, add sterile water for injection, 40,000 mg of phosphoric acid, 120,000 mg of L-arginine, 16,000 mg of mannitol, and 400 mg of Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain a solution B, the concentration of the solution is calculated as 2 mg / ml based on batroxobin;

[0049] 3) Mix solution A and solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml steril...

Embodiment 3

[0050] Example 3 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0051] Prescription: batroxobin 6000 mg, citicoline 3000 mg, ginkgolide B 2800 mg, protoporphyrin sodium 70 mg.

[0052] Preparation:

[0053] 1) Take the prescribed amount of citicoline and sodium protoporphyrin, mix them, add sterile water for injection and dissolve to obtain solution A, and the concentration of the solution is 5 mg / ml based on citicoline;

[0054] 2) Take the prescribed amount of batroxobin, add sterile water for injection, 60,000 mg of phosphoric acid, 180,000 mg of L-arginine, 24,000 mg of mannitol, and 600 mg of Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain a solution B, the concentration of the solution is calculated as 2 mg / ml based on batroxobin;

[0055] 3) Mix solution A and solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml st...

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Abstract

The invention belongs to the field of medicines, and particularly relates to a medicinal composition for treating acute cerebral ischemic stroke. The medicinal composition is prepared from pharmaceutically acceptable medicinal auxiliary materials, batroxobin, citicoline, ginkgolide and protoporphyrin sodium. The dosage form of the medicinal composition is preferably lyophilized powder for injection. The protoporphyrin sodium in the medicinal composition has a significant effect of enhancing the batroxobin functions of preventing thrombosis and improving cerebral blood perfusion, so that improvement on the cerebral ischemic stroke treating effect of the batroxobin is benefited.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pharmaceutical composition for treating acute ischemic stroke. Background technique [0002] Cerebral ischemic stroke is a brain tissue necrosis and neurological impairment caused by local blood supply and inflammation caused by blood circulation disturbance in the brain, usually caused by stenosis or thromboembolism of blood supply vessels in the brain. Ischemic stroke accounts for more than 85% of strokes and is currently the most fatal and disabling disease. Post-stroke hemiplegia and loss of mobility are the main problems that plague the majority of patients. [0003] Acute ischemic stroke (Acute cerebral arterial thrombosis) is the main type of ischemic stroke, accounting for about 60-80% of the total number of stroke patients. There are approximately 1.5 to 2 million new patients with acute ischemic stroke in China every year. The case fatality rate is about 80-120 / 100,000 peopl...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/19A61P9/10A61K31/7068A61K31/365A61K31/409
CPCA61K9/19A61K31/365A61K31/409A61K31/7068A61K38/4806A61K2300/00
Inventor 张惊宇谢芳萍张力娜
Owner 张惊宇
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