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Method for preparing main ingredient in mangosteen shells and application of main ingredient in pharmacy

A technology of mangosteen husk and mangosteen shell, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, plant/algae/fungus/moss ingredients, etc., which can solve the problems of long time, low yield and restricted ingredient purification and application issues, to achieve the effects of low production cost, wide range of uses, and simple and easy operation

Inactive Publication Date: 2018-01-19
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In these previous research works, a large number of column chromatography separation methods such as silica gel columns, reversed-phase materials, and gel molecular exclusion chromatography were used. The time was long and the yield was not high, which restricted the purification and application of such components.

Method used

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  • Method for preparing main ingredient in mangosteen shells and application of main ingredient in pharmacy
  • Method for preparing main ingredient in mangosteen shells and application of main ingredient in pharmacy
  • Method for preparing main ingredient in mangosteen shells and application of main ingredient in pharmacy

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Take 1500g of dried mangosteen husk powder, add 80% ethanol at a ratio of 1:5, reflux and extract at 90°C for 180min, cool to room temperature, filter with suction, repeat the extraction once more, combine the filtrates twice, concentrate under reduced pressure to recover ethanol, and obtain Mangosteen husk crude extract extract, dissolve extract with 30% ethanol water, centrifuge (4000rpm / min, 10min), get supernatant and precipitate, transfer to freeze-drying box respectively, dry, and obtain red powder after crushing respectively Shape, yellow powder. Calculated by raw materials, the yield of the red product is 21.93% (after consulting the literature, the main component of the red product is proanthocyanidins), and in the red powder, the epicatechin content is 1.24%; the yield of the yellow powder product is 9.6% ( After consulting the literature, the main component of the yellow product is mangostin), and in the yellow powder, the content of α-mangostin is 49.05%; th...

Embodiment 2

[0057] Take 2400g of dried mangosteen husk powder, add 80% ethanol at a ratio of 1:6, reflux extraction at 92°C for 150min, cool to room temperature, filter with suction, repeat the extraction once more, combine the filtrates twice, concentrate under reduced pressure and recover ethanol to obtain Mangosteen husk crude extract extract, dissolve extract with 30% ethanol water, centrifuge (4000rpm / min, 10min), get supernatant and precipitate, transfer to freeze-drying box respectively, dry, and obtain red powder after crushing respectively Shape, yellow powder. Calculated by raw materials, the yield of the red product is 16.4% (through research, it is proved that the main component of the red product is proanthocyanidins), and in the red powder, the content of epicatechin is 1.26%; the yield of the yellow powder is 7.8% (After consulting the literature, the main component of the yellow product is mangostin). In the yellow powder, the content of α-mangostin is 49.2%; the content o...

Embodiment 3

[0059] Take 7000g of dried mangosteen husk powder, add 80% ethanol at a ratio of 1:5, reflux and extract at 92°C for 180min, cool to room temperature, filter with suction, repeat the extraction once more, combine the filtrates twice, concentrate under reduced pressure to recover ethanol, and obtain Mangosteen husk crude extract extract, dissolve extract with 30% ethanol water, centrifuge (4000rpm / min, 10min), get supernatant and precipitate, transfer to freeze-drying box respectively, dry, and obtain red powder after crushing respectively Shape, yellow powder. Calculated by raw materials, the yield of the red product is 15.6% (through literature review, the main component of the red product is proanthocyanidins). In the red powder, the content of epicatechin is 1.40%; the yield of the yellow powder product is 7.2% (by Check the literature, the main component of the yellow product is mangostin), in the yellow powder, the content of α-mangostin is 49.5%; the content of γ-mangost...

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Abstract

The invention provides a method for preparing mangostin-enriched ingredient and procyanidine-enriched ingredient in mangosteen shells and application of the prepared substances in medicines, health products and skin-care products. According to the method, massive pigments and main chemical ingredients in the mangosteen shells are researched and developed, pigments and xanthone are extracted from waste mangosteen shells, so that the production cost of pigments and xanthone can be reduced, shells are recycled, and technical basis is provided to further development and utilization of the mangosteen shells.

Description

technical field [0001] The invention belongs to the field of biomedicine and health, and in particular relates to a method for preparing its main component from mangosteen husk, and its application in the preparation of health care products and skin care products. Background technique [0002] Mangosteen (Garcinia mangostana), also known as mangosteen and mangosteen, is a tropical evergreen tree belonging to the genus Garcinia of the family Guttiferae. The mangosteen fruit is a spherical fruit, the thick and hard shell is purple-red, the pulp accounts for 29-45% of the fruit weight, and the shell accounts for about 50% of the fresh weight. In Southeast Asian countries, mangosteen husk has been used as traditional medicine for skin diseases. Many studies have found that mangosteen husk contains a large amount of xanthone, which is a traditional polyphenolic acid substance, which has anti-inflammatory, anti-oxidation, anti-thrombotic, anti-tumor activities, and is effective a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/38A61P39/06A61P35/00A61P31/04A61P29/00A61P7/02A61K8/9789A61Q19/00A61Q19/02A23L33/105A61K131/00
CPCY02A50/30
Inventor 胡江苗杨柳袁明焱徐顶巧周俊
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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