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A kind of preparation method of Jinma Gantai preparation

A technology of Jinmagantai and Jinmagantai, which is applied in the field of preparation of Jinmagantai preparations, can solve the problems of loss of active ingredients, incomplete removal of impurities, and large loss of active ingredients, so as to increase the content of active substances, avoid heat volatilization loss, The effect of purification process stability

Active Publication Date: 2021-02-09
GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method simply uses water extraction and alcohol precipitation process to extract and purify six kinds of traditional Chinese medicines except Rhizoma Chrysanthemum, Fangji, and Epimedium. Small molecule active ingredients such as alkaloids, flavonoids, saponins, and organic acids will be lost to varying degrees, and a large part of the active ingredients will be lost due to the adsorption and encapsulation during the alcohol precipitation process. Influenced by concentration and human factors, the removal rate and type of impurities vary greatly
In addition, the alcohol precipitation process causes a serious loss of total solids and active ingredients, and the amount of ethanol is large, the recovery rate is low, and the production cycle is long. After alcohol precipitation treatment, the content of its active ingredients is affected, and the intrinsic quality of the finished product is greatly reduced.
After the precipitation is removed, ethanol must be recovered. This process of recovering ethanol is not only time-consuming and energy-consuming, but also has a great impact on the active ingredients of traditional Chinese medicine.
[0005] Although "refining" by alcohol precipitation method is the main mode of industrial production in most pharmaceutical factories at present, due to its disadvantages such as large loss of active ingredients, incomplete removal of impurities, and poor stability, it is necessary to seek new technologies and new processes to replace water extraction. Alcohol precipitation method is imperative

Method used

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  • A kind of preparation method of Jinma Gantai preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 Jinmagantai capsule

[0046] Prescription: Horseshoe Gold 960.7g, Iron-clad Gold 511g, Verbena 383.3g, Fangji 638.7g, Patrinia 383.3g, Epimedium 511g, Astragalus 511g, Radix Paeoniae Rubra 511g, Salvia miltiorrhiza 766.7g

[0047] Process:

[0048] (1) Grind the water chestnut into a coarse powder, reflux extract with 6 times the amount of 90% ethanol for 3 times, each time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate it to a thick paste with a relative density of 1.34 to 1.40 at 50 to 60°C Ointment, spare;

[0049] (2) Fangji is dried and pulverized into a coarse powder, extracted 3 times with 85% ethanol under reflux, each time for 1 hour, combined the extracts, recovered the ethanol until there is no alcohol smell, added 1% hydrochloric acid drop by drop under stirring, to make PH=5 , stand still for 48 hours, filter, adjust the pH to 9 with concentrated ammonia water, and suction filter after standin...

Embodiment 2

[0056] The preparation of embodiment two Jinmagantai granules

[0057] Prescription: Horseshoe Gold 1000g, Iron-clad Gold 600g, Verbena 450g, Fangji 700g, Patrinia 450g, Epimedium 600g, Astragalus 600g, Radix Paeoniae Rubra 600g, Salvia miltiorrhiza 800g

[0058] Process:

[0059] (1) Grind the water chestnut into a coarse powder, reflux extract with 6 times the amount of 90% ethanol for 3 times, each time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate it to a thick paste with a relative density of 1.34 to 1.40 at 50 to 60°C Ointment, spare;

[0060] (2) Fangji is dried and pulverized into a coarse powder, extracted 3 times with 85% ethanol under reflux, each time for 1 hour, combined the extracts, recovered the ethanol until there is no alcohol smell, added 1% hydrochloric acid drop by drop under stirring, to make PH=5 , stand still for 48 hours, filter, adjust the pH to 9 with concentrated ammonia water, and suction filter after standing for ...

Embodiment 3

[0067] The preparation of embodiment three Jinmagantai tablets

[0068] Prescription: Horseshoe Gold 900g, Iron-coated Gold 450g, Verbena 300g, Fangji 600g, Patrinia 300g, Epimedium 450g, Astragalus 450g, Radix Paeoniae Rubra 450g, Salvia miltiorrhiza 700g

[0069] Process:

[0070] (1) Grind the water chestnut into a coarse powder, reflux extract with 6 times the amount of 90% ethanol for 3 times, each time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate it to a thick paste with a relative density of 1.34 to 1.40 at 50 to 60°C Ointment, spare;

[0071] (2) Fangji is dried and pulverized into a coarse powder, extracted 3 times with 85% ethanol under reflux, each time for 1 hour, combined the extracts, recovered the ethanol until there is no alcohol smell, added 1% hydrochloric acid drop by drop under stirring, to make PH=5 , stand still for 48 hours, filter, adjust the pH to 9 with concentrated ammonia water, and suction filter after standing fo...

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Abstract

The invention discloses a preparation method of Jinmagantai preparation, which belongs to the technical field of traditional Chinese medicine preparations. Jinmagantai preparations are prepared from horseshoe gold, iron-coated gold, verbena, fangji, Patrinia, epimedium, astragalus, red peony root, salvia miltiorrhiza and auxiliary materials; The categories and properties of active ingredients are classified and extracted from Chinese medicinal materials, and the combination of high-speed centrifugation and macroporous adsorption resin is used to extract and purify the effective substances of each traditional Chinese medicine to the maximum extent, and to improve the curative effect of Jinmagantai preparations on acute and chronic hepatitis , compared with the prior art, the product prepared by the process of the present invention has high active ingredient content, good clinical curative effect, non-toxic and stable preparation, simple extraction and purification process, and can be applied industrially.

Description

technical field [0001] The invention relates to a preparation method of Jinma Gantai preparation, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Pain and burning in the flanks, abdominal distension and anorexia, bitter mouth and nausea, short red or yellow urine, irregular stool, or yellow body and eyes, red tongue with yellow greasy coating, and rapid pulse are common clinical symptoms. Traditional Chinese medicine often treats it by soothing the liver and nourishing blood, regulating qi and removing blood stasis. Traditional Chinese medicine believes that the lack of righteousness makes it very easy to be infected with epidemic toxins. Bad eating habits damage the spleen and stomach and cannot eliminate dampness. Or acute and chronic hepatitis caused by stagnation of qi and blood stasis due to stagnation of damp evil and long-term heat accumulated in the liver and gallbladder, damp and heat in the liver and gal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61P1/16
Inventor 薛捷田紫平蒋禹章杨胜国李辉何容
Owner GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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