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VVYP used for preventing and/or treating liver injuries

A technology for liver injury and chemical liver injury, applied in the directions of antitoxins, digestive system, tetrapeptide components, etc., to reduce the pathological changes of liver tissue, repair liver damage, and protect the liver.

Active Publication Date: 2018-01-09
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no record in the prior art about the protective effect of Val-Val-Tyr-Pro peptide on the prevention and treatment of liver damage

Method used

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  • VVYP used for preventing and/or treating liver injuries
  • VVYP used for preventing and/or treating liver injuries
  • VVYP used for preventing and/or treating liver injuries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 The protective effect of Val-Val-Tyr-Pro peptide on acute liver injury in mice caused by carbon tetrachloride

[0065] 1. Materials and methods

[0066] (1) Materials and main reagents

[0067] Test animals: Clean grade KM mice, male, 120, 18-22g

[0068] Test drug:

[0069] Val-Val-Tyr-Pro peptide: 99% pure, provided by Jiangxi Bencao Tiangong Technology Co., Ltd.

[0070] Bicyclol Tablets: National Pharmaceutical Zhunzi H20040467, Beijing Union Pharmaceutical Factory

[0071] Silybin: National Pharmaceutical Standard H20040299, Tianjin Tasly Sainte Pharmaceutical Co., Ltd.

[0072] Carbon tetrachloride was purchased from Tianjin Fuchen Chemical Reagent Factory

[0073] Alanine aminotransferase (ALT) kit, aspartate aminotransferase (AST), total bilirubin (TBIL), total cholesterol (CHO1) and triglyceride (TG) kit were purchased from Japan Wako Pure Chemical Industry Co., Ltd.

[0074] The superoxide dismutase (SOD) kit was purchased from Nanjing Jianchen...

Embodiment 2

[0114] Example 2: Protective effect of Val-Val-Tyr-Pro peptide on acute alcoholic liver injury in mice

[0115] 1. Materials and methods

[0116] (1) Material

[0117] Alcohol content 56%, purchased from Beijing Red Star Wine Co., Ltd.

[0118] Others are the same as embodiment 1

[0119] (2) Main instruments

[0120] Same as Example 1

[0121] (3) method

[0122] Grouping of experimental animals: 70 Kunming mice were randomly divided into blank control group, model group, positive drug silibinin group (75mg / kg), positive drug bicyclol group (25mg / kg), Val-Val-Tyr-Pro Peptide high dose group (25mg / kg), Val-Val-Tyr-Pro peptide medium dose group (12.5mg / kg), Val-Val-Tyr-Pro peptide low dose group (6.25mg / kg), 10 rats in each group animal.

[0123] Experimental animal dosing: The mice in each group of the dosing group were given the corresponding medicine once in the morning, afternoon and morning of the next day in random order, and the dosing method was intragastric admi...

Embodiment 3

[0132] Example 3 Protective effect of Val-Val-Tyr-Pro peptide on acute liver injury in mice induced by acetaminophen

[0133] 1. Materials and methods

[0134] (1) Material

[0135] Alcohol content 56%, purchased from Beijing Red Star Wine Co., Ltd.

[0136] Others are the same as embodiment 1

[0137] (2) main instrument: with embodiment 1

[0138] (3) method

[0139] Experimental animal grouping: 72 Kunming mice were randomly divided into blank control group, model group, bicyclol low-dose group (25mg / kg), bicyclol high-dose group (50mg / kg), Val-Val-Tyr-Pro peptide High-dose group (32mg / kg), Val-Val-Tyr-Pro peptide middle-dose group (16mg / kg), Val-Val-Tyr-Pro peptide low-dose group (8mg / kg), 12 animals in each group.

[0140] Experimental animal dosing: The mice in each group of the dosing group were given the corresponding medicine once in the morning, afternoon and morning of the next day in random order, and the dosing method was intragastric administration, and the ...

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Abstract

The invention relates to applications of peptide as shown in the sequence Val-Val-Tyr-Pro in preparing medicines for preventing and / or treating liver injuries and in preparing medicines for reducing transaminase.

Description

technical field [0001] The present invention relates to the use of VVYP (that is, the peptide represented by the sequence Val-Val-Tyr-Pro) in the preparation of drugs for preventing and / or treating liver damage. Background technique [0002] In recent years, liver damage caused by factors such as viral infection, drugs, chemical poisons (such as chemical pollutants in the environment, etc.), alcoholism, is increasingly endangering people's health. Liver damage can induce hepatitis, cirrhosis and even liver cancer, seriously affecting the quality of life and health. China is recognized as a major hepatitis country in the world, with about 130 million hepatitis virus carriers. Environmental pollution brought about by China's rapid economic development, increasing alcohol consumption, irrational use and abuse of drugs, and the resulting chemical, alcoholic and drug-induced liver injuries are increasing year by year in my country. Therefore, there is a huge market demand for d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/07A61P1/16A61P35/00A61P39/02
Inventor 金一王日康孙勇兵杨世林
Owner JIANGXI HERBFINE HI TECH
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