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Novel bactericidal ultrasonic gel for tracts and preparation method thereof

A kind of bactericidal effect and a new type of technology, which is applied in the field of new ultrasonic gel for cavity and its preparation, and achieves the effects of ensuring physical health, reducing production costs, and having safe and reliable performance.

Inactive Publication Date: 2018-01-05
安徽深蓝医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical practice, the couplant also acts as a lubricant, so people are not only concerned about its acoustic properties, but also the risk of iatrogenic infection caused by the use of the couplant has attracted more and more attention.

Method used

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  • Novel bactericidal ultrasonic gel for tracts and preparation method thereof
  • Novel bactericidal ultrasonic gel for tracts and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one: get chitosan 1g by weight, trichlorohydroxy diphenyl ether 0.1g, chlorhexidine acetate 0.1g, add polysorbate 80 altogether 1g, then add purified water 100g, mix uniformly; Add 300g of purified water to 10g to swell, and then add the mixed solution prepared above; after stirring the solution evenly, add 10g of glycerin and triethanolamine to adjust the viscosity and pH so that the viscosity (25°C) is not less than 15Pa·s ; PH value 5.5 ~ 8.0; dilute to 1000g with purified water.

Embodiment 2

[0019] Embodiment two: get chitosan 2g by weight, trichlorohydroxy diphenyl ether 0.2g, chlorhexidine acetate 0.2g, add polysorbate 80 to count 2g, add purified water 100g again, mix homogeneously; First add 300g of purified water to 20g to swell, and then add the mixed solution prepared above; after stirring the solution evenly, add 20g of glycerin and triethanolamine to adjust the viscosity and pH so that the viscosity (25°C) is not less than 15Pa·s; PH value 5.5~8.0; use purified water to make up to 1000g.

Embodiment 3

[0020] Embodiment three: get chitosan 3g by weight, trichlorohydroxy diphenyl ether 0.3g, chlorhexidine acetate 0.3g, add polysorbate 80 to count 3g, add purified water 100g again, mix homogeneously; First add 300g of purified water to 30g to swell, and then add the above-mentioned mixed solution; after stirring the solution evenly, add 30g of glycerin and triethanolamine to adjust the viscosity and pH so that the viscosity (25°C) is not less than 15Pa·s; PH value 5.5~8.0; use purified water to make up to 1000g.

[0021] The following experiments prove that the clinical use of the product of the present invention can kill and inhibit the cross-infection and transmission of Gram bacteria, fecal coliform colonies, Pseudomonas aeruginosa, fungi, etc. caused by the contact between the probe and the human body during the ultrasonic diagnostic inspection process.

[0022] Among the 100 samples selected comprehensively, 50 cases of transcutaneous ultrasound, 35 cases of transvaginal ...

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Abstract

The invention belongs to the field of biomedicine, and discloses a novel ultrasonic gel for cavity with bactericidal effect and a preparation method thereof. The ingredients include chitosan, trichlorohydroxydiphenyl ether, chlorhexidine acetate, polysorbate 80, Carbomer, Glycerin, Triethanolamine, Purified Water. The invention can not only keep the convenience of the existing coupling gel, but also achieve the advantages of clear image, good lubricating performance, no corrosion damage to the probe, no irritation to the skin and mucous membrane, no allergy, absorbability and the like. In terms of main performance, the viscosity (25°C) is not less than 15Pa·s; the pH value is 5.5-8.0; it can kill and inhibit the Gram bacteria, fecal coliform colonies, Pseudomonas aeruginosa, Cross-infection and transmission of fungi and the like. It is clinically used for vaginal ultrasonography, non-intact skin examination, proctoscopy, cystoscopy, puncture examination, high-risk groups, examination of patients with severe infection, all ultrasonography in intensive care unit; all other ultrasonography will be safer.

Description

technical field [0001] The invention relates to a novel ultrasonic gel for cavities with bactericidal effect and a preparation method thereof, which can be widely used in the field of medical ultrasonic examination and treatment of various parts such as skin, cavities, and punctures. Background technique [0002] Medical ultrasonic gel is an indispensable medium in ultrasonic diagnosis and treatment. For medical ultrasound, if the probe (or treatment head, the same below) is in "dry contact" with the skin, due to the strong reflection of the thin (or sometimes thick) air layer between the two, the ultrasonic wave cannot reach and enter the human body at all. , ultrasound diagnosis or treatment is out of the question. To do this, something must be filled between the surface of the probe and the skin to drive out the air and form a channel for the smooth and undistorted transmission of ultrasound. This substance is called "medical ultrasonic coupling agent (medical ultrasoni...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K9/06A61K31/722A61K47/26A61K47/32A61P31/04A61P31/10A61K31/155A61K31/085
Inventor 张超陈奉玲金国乐
Owner 安徽深蓝医疗科技股份有限公司
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