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Calcium-based dentifrice for enhanced absorption of active ingredients

A technology of antibacterial agent and average molecular weight, applied in the field of oral care composition, can solve the problems of increasing batch cycle time, increasing preparation cost, etc.

Inactive Publication Date: 2021-04-23
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, containing even lower amounts of GANTREZ TM and Combinations of HV clays may increase formulation cost prohibitively
Additionally, clay-containing formulations are known to increase batch cycle time due to mixing and hydration requirements

Method used

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  • Calcium-based dentifrice for enhanced absorption of active ingredients
  • Calcium-based dentifrice for enhanced absorption of active ingredients
  • Calcium-based dentifrice for enhanced absorption of active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Example 1 - Dentifrice Formulation

[0110] Seven dentifrice formulations A, C, D, E, F, G and H were prepared by mixing the ingredients in the amounts specified in Table 1 as described below. Include The competitor's dentifrice formulation is called Formulation B (Table 2).

[0111] A stainless steel vessel (SS vessel) equipped with a stirrer was charged with 70% sorbitol and heated to 60°C while stirring. Pasteurized, filtered, purified water was added to the sorbitol and heated to 85°C.

[0112] A premix containing carrageenan, sodium monofluorophosphate, sodium saccharin and sodium bicarbonate was slowly added to a separate container (SS container) to form a gel mass. The gel mass was mixed at a temperature ranging from 64°C to 65°C until no lumps were observed (approximately 20 minutes). 0.5% by weight pasteurized water was added to the SS vessel to compensate for water loss. The gelled mass was then transferred to a stainless steel mixing vessel (Alpro sti...

Embodiment 2

[0123] Example 2. Absorption and retention

[0124] Using saliva-coated hydroxyapatite (SCHAP) discs (i.e., the mineral phase of tooth enamel) as an in vitro experimental model of human teeth, the effects of polyethylene glycol (such as PEG 6000) in oral care compositions of the present disclosure on teeth were evaluated. Effect of surface absorption and retention of triclosan. In vitro assessments were found to correlate with in vivo delivery and retention of antimicrobial agents on oral surfaces.

[0125] To test the rate of triclosan uptake by SCHAP discs, parafilm-stimulated whole saliva was collected into beakers and clarified by centrifugation at 10,000 rpm for 10 minutes. Hydrate each hydroxyapatite disc with sterile water in a test tube. The water is then removed and replaced with 2 ml of clarified saliva. Salivary films were formed by incubating the discs overnight at 37°C with continuous shaking in a water bath. After this treatment, excess saliva was removed b...

Embodiment 3

[0128] Example 3. Results

[0129] As demonstrated in Table 2, high molecular weight polyethylene glycols such as PEG 6000 unexpectedly increased the rate of absorption (0 hours) and retention (4 hours) of antimicrobial agents such as triclosan. As shown in Table 2, formulations containing PEG6000 had better absorption at 0 hours than Control Formulation A on hydroxyapatite (HAP) discs. For example, as seen in Table 2, formulations containing PEG-6000 resulted in the presence of 24 μg on hydroxyapatite discs at 0 hours (Formulation E) compared to Control Formulation A (i.e. 18 μg Triclosan / HAP at 0 hours). , 20 μg (formulation F) and 38 μg (formulation G) of triclosan. see also figure 1 .

[0130] In addition, Table 2 also shows that formulations containing PEG 6000 had better retention than Control Formulation A at 4 hours on hydroxyapatite discs. For example, as seen in Table 2, formulations containing PEG-6000 resulted in the presence of 11 μg on hydroxyapatite discs ...

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Abstract

The present invention discloses an oral care composition comprising (i) a calcium-based abrasive; (ii) polyethylene glycol having an average molecular weight of about 1500 to about 6000 (iii) antibacterial agents; and (iv) orally acceptable vehicles. The invention also discloses methods of preparing the oral care composition and using the oral care composition to promote oral health.

Description

[0001] Cross references to related patent applications [0002] This application claims the benefit of priority from Indian Patent Application No. 1132 / DEL / 2015 filed 23 April 2015, the entire content of which is incorporated herein by reference. Background technique [0003] Oral care compositions, such as toothpastes, generally come in two types: opaque and clear. Opaque toothpastes often contain calcium-based abrasives, such as calcium carbonate. In contrast, clear (eg, gel) toothpastes typically contain silica as an abrasive. Any of these formulations may beneficially contain an antibacterial agent, such as 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan). However, delivery of antimicrobial agents often requires the use of vinyl methyl ether and maleic acid polymers such as GANTREZ TM . Such polymers, which are widely used in silica-based toothpaste, improve the absorption and retention of antimicrobial agents by, for example, entrapping them and then adhering them t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/19A61K8/24A61K8/34A61K8/86A61Q11/00
CPCA61K8/347A61Q11/00A61K8/86A61K8/24A61K2800/28A61K8/19A61P31/04A61K2800/48
Inventor 沙尚克·维什瓦纳特·波特尼斯罗兰多·普拉塔阿米特·希尔德赛塞格尔·滕贝纳文·刘易斯
Owner COLGATE PALMOLIVE CO
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