A detection method of a pharmaceutical preparation of Houpu Qiwu Decoction
A technology for pharmaceutical preparations and detection methods, which is applied in the field of detection of pharmaceutical preparations, and can solve problems such as the inability to systematically and comprehensively reflect the inherent quality, type and content of Houpu Qiwutang granules.
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Embodiment 1
[0130] The raw materials of Houpu Qiwu Decoction Granules are as follows: Magnolia officinalis 24g, licorice 9g, rhubarb 9g, jujube 25g, citrus aurantium 10g, cassia twig 6g, ginger 15g;
[0131] The preparation method is as follows: respectively take magnolia officinalis, licorice, rhubarb, jujube, citrus aurantium, cassia twig and ginger in selected parts by weight, add water to decoct twice, add 12 times the amount of water for the first time, decoct for 2 hours, Add 10 times the amount of water for the second time, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.30 at 60°C, dry it, add conventional excipients, and make clinical acceptable granules.
Embodiment 2
[0133] The present embodiment establishes the method for the fingerprint of Hopu Qiwu Decoction granule, comprises the following steps:
[0134] Take the granules of Houpu Qiwu Decoction to be tested, grind it finely, take 1g, weigh it accurately, put it in a stoppered conical flask, add 25mL of methanol aqueous solution with a volume concentration of 80% precisely, weigh it, treat it with ultrasonic for 30 minutes, take it out , allowed to cool, then weighed again, with 80% aqueous methanol solution to make up the lost weight, shake well, filter, and get the filtrate to obtain the test solution;
[0135] Take an appropriate amount of naringin reference substance, weigh it accurately, add methanol aqueous solution with a volume concentration of 80% to make a solution containing 4 mg of naringin per 1 mL, shake well, and obtain the reference substance solution;
[0136] Using octadecylsilane bonded silica gel as filler, acetonitrile as mobile phase A, and 0.1% phosphoric acid a...
Embodiment 3
[0139] The present embodiment establishes the method for the fingerprint of Hopu Qiwu Decoction granule, comprises the following steps:
[0140] Take the granules of Houpu Qiwu Decoction to be tested, grind it finely, take 0.5g, accurately weigh it, put it in a stoppered Erlenmeyer flask, add precisely 10mL of methanol aqueous solution or methanol with a volume concentration of 95%, weigh it, and ultrasonically reflux or Shake for 60 minutes, take it out, let it cool, weigh again, make up the lost weight with methanol water or methanol with a volume concentration of 95%, shake well, filter, and take the subsequent filtrate to obtain the test solution;
[0141] Take an appropriate amount of naringin reference substance, weigh it accurately, add methanol aqueous solution with a volume concentration of 95% to make a solution containing 1 mg of naringin per 1 mL, shake well, and obtain the reference substance solution;
[0142] Using octadecylsilane bonded silica gel as filler, ac...
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