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Method for measuring medicines and personal care products in water samples

A technology for personal care and water samples, applied in measuring devices, instruments, scientific instruments, etc., can solve problems such as inapplicability to PPCPs detection, and achieve the effects of low cost, high sensitivity and low detection limit

Inactive Publication Date: 2017-12-19
BEIJING WATER SCI & TECH INST
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  • Claims
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Problems solved by technology

PPCPs are generally substances with high boiling points, and the commonly used detection instruments such as GC-MS are not suitable for the detection of PPCPs

Method used

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  • Method for measuring medicines and personal care products in water samples
  • Method for measuring medicines and personal care products in water samples
  • Method for measuring medicines and personal care products in water samples

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Embodiment

[0078] Utilize the method of the present invention, certain reclaimed water and groundwater irrigated with regenerated water are sampled, and 13 kinds of PPCPs are analyzed wherein, namely sulfamethoxine, sulfathiazole, acesulfamethoxazole, sulfisoxazole, sulfachloropyridazine , sulfamethazine, sulfamethazine, trimethoprim, chloramphenicol, ibuprofen, sulfamethoxazole, estrone (E1), estriol (E3).

[0079] Specific operation: Take 2 L of water sample filtered with a 0.45 μm glass fiber membrane, and add the substitute ibuprofen-D3 at a concentration of 200 ng / L. Use 5mL of acetonitrile, methanol and ultrapure water to activate the HLB column of Waters Company and the Envi-18 solid phase extraction (SPE) column of Supelco Company in turn, pass through the solid phase extraction device, the water sample added with the substitute is evenly passed through the For the activated SPE cartridge, the flow rate of the water sample passing through the column is about 6mL / min until it is d...

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Abstract

The invention relates to a method for measuring medicines and personal care products in water samples. The method comprises the following steps: 1) measuring standard samples of a target object and a substituent by using LC-MS / MS to calculate response factors of the target object and the substituent; 2) preparing simulated water samples and enriching the simulated water samples by connecting solid-phase extracting small columns with different polarity in series to calculate the absolute recovery rate of the target object and the substituent in the simulated water samples; 3) adding the substituent with a certain concentration into the to-be-detected water samples and enriching the water samples by using the solid-phase extracting small columns which are connected in series; 4) detecting the enriched water samples by using LC-MS / MS; 5) calculating the concentration Cx of the to-be-detected target object in the water samples. The method has the advantages of simplicity in pretreatment, low cost, low detection limit, high sensitivity and the like, and is suitable for sensitive and accurate qualitative and quantitative analysis of a trace amount of PPCPs in different water.

Description

technical field [0001] The invention relates to a method for determining pharmaceuticals and personal care products in water samples, and more particularly to a method for detecting 13 kinds of pharmaceuticals and personal care products (PPCPs) by liquid chromatography-mass spectrometry. Background technique [0002] A large number of pharmaceuticals and personal care products (PPCPs) were detected in water bodies, making them a research hotspot of international environmental pollution problems and a typical representative of emerging pollutants. The source of PPCPs in the environment is closely related to human activities. PPCPs are directly or indirectly discharged into the environment after humans or animals take drugs as the main source, such as sulfamethoxine, sulfathiazole, acesulfamethoxazole, Sulfaisoxazole, sulfachloropyridazine, sulfamethazine, sulfamethazine, trimethoprim, chloramphenicol, ibuprofen, sulfamethoxazole, estrone (E1), estriol (E3), etc. Wait. A lar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/88G01N30/06G01N2030/062G01N2030/884
Inventor 李炳华黄俊雄郝仲勇梁存珍韩丽李其军杨勇刘立才
Owner BEIJING WATER SCI & TECH INST
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