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Adsorption material for blood purification and preparation method thereof

An adsorption material and blood purification technology, applied in chemical instruments and methods, blood circulation treatment, other chemical processes, etc., can solve problems such as poor blood compatibility, hidden dangers to patient health and safety, and destruction of formed components, and achieve stereoselectivity Strong, personalized and functional, simple reaction conditions

Active Publication Date: 2017-12-19
GUANGZHOU KONCEN BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of this synthetic technology route will easily lead to the residue of strong irritating chemical substances chloromethyl ether and nitrobenzene, both of which are strong carcinogens and have great potential safety hazards to the health of patients
Moreover, the adsorbent resin usually has poor blood compatibility, and its direct contact with blood will destroy formed components such as red blood cells, white blood cells and platelets.

Method used

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  • Adsorption material for blood purification and preparation method thereof
  • Adsorption material for blood purification and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Synthesis of adsorbent materials for blood purification by photoinitiated polymerization:

[0054] 1. Synthesis of low-density lipoprotein adsorption material

[0055] (1) Add 18wt% sodium hydroxide solution to the resin, pretreat at 20°C for 24 hours, then filter and rinse until the rinse solution is neutral, and dry in the air;

[0056] (2) Under the condition of 4 ℃ and dark, soak the resin obtained in step (1) with 0.10wt% photoinitiator Quantacure BTC and 0.10wt% acrylic acid monomer solution for 4h, then suction filter to obtain the photoinitiator deposited on the surface and acrylic resins;

[0057] (3) Place the resin with photoinitiator and acrylic acid deposited on the surface of the obtained step (2) in the photoreactor, form a 1.0cm thick resin layer at the bottom of the photoreactor, then add a quartz glass upper cover, and deoxygenate with nitrogen for 8min After that, turn on the UV light for 20 minutes;

[0058] (4) Soak in water to clean the resin ob...

Embodiment 2

[0065] Synthesis of Adsorbent Materials for Blood Purification by Plasma Jet Deposition:

[0066] Resin as a carrier

[0067] 1. Activated resin

[0068] on the resin surface by using NH 3 Plasma polymerization method (Plasma Science, USA, Type PS 0350 Plasma Surface Treatment System) for modification, code number PD-0.

[0069] The amount of primary amines on the surface of the obtained resin was determined by trinitrotoluene sulfonate (TNBS) assay.

[0070] 2. Synthetic protein A immunoadsorbent material

[0071] The resin PD-0 was added to a mixed solution of 0.25 times the mass of glutaraldehyde and 2 times the mass of 0.2M phosphate buffer (pH 7.4), and reacted at 37° C. and 120 rpm for 3 hours. After washing with pH 7.4, 0.1M phosphate buffer, add the resin to borate buffer containing 3M mercapto-ammonium acid ammonium of SPA 3mg / mL, pH 8.2, 37℃, 120rpm for 24h, and then use pH7 .4. Wash with 0.1M phosphate buffer, and finally use NaBH 3 The double bond generated d...

Embodiment 3

[0093] Mercapto-ene click reaction synthesis of adsorbent materials for blood purification:

[0094] Resin as a carrier

[0095] 1. Ligand thiolation

[0096] First activate cysteine, add 1eq cysteine, 2-(7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU, 2eq ) as condensing agent, N,N-diisopropylethylamine (DIPEA) (4eq) as base, N,N-dimethylformamide (DMF) as solvent, react at room temperature, and then add 2eq amino group The ligand (n-butylamine, polymyxin B sulfate, colistin B, lysozyme) was reacted for 6 hours to obtain the thiolated ligand, numbered QX-0.

[0097] 2. Synthesis of Bilirubin Adsorbent Material

[0098] 2g of mercaptolated n-butylamine was dissolved in 20ml of absolute ethanol, 2mg of photoinitiator was added, and then added to the resin after swelling and suction filtration washing with ethylene dichloride (in the system, the carbon-carbon double bond and thiol The molar ratio is 1:1), light reaction under 254nm ultraviolet lig...

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Abstract

The invention discloses an adsorption material for blood purification and a preparation method thereof. The adsorption material is prepared by coupling a functionalization area with at least one ligand, wherein the functionalization area is formed by a carrier with 0.05-2mm particle size alone or by performing surface modifying on the carrier with 0.05-2mm particle size; and the ligand is capable of binding to at least one pathogenic component in blood or plasma, so that at least one pathogenic composition in whole blood or plasma can be selectively adsorbed. For the adsorption material disclosed by the invention, functional polymers and different ligands are introduced onto the surface of the carrier by using different methods according to different blood purification requirements, so as to achieve an effect of reducing circulating pathogenic substances and harmful pro-inflammatory mediators in a human body, and achieve personalized and functional aims of the adsorption material for blood purification. The adsorption material has the good market value and application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical related materials and blood purification, more specifically, the invention relates to an adsorption material, its preparation method and its application in blood purification. Background technique [0002] The occurrence and development of many diseases are the result of the accumulation of pathogenic factors in the body. It is a problem that clinical medicine has been constantly exploring in recent years to specifically and effectively remove these pathogenic factors from the body through the method of purifying the blood without causing damage to the body. One of the important methods is the adsorption therapy of blood purification. Its principle is to firmly bind a ligand to a fixed carrier to form an adsorption column, and specifically adsorb and remove pathogens in the patient's blood through extracorporeal circulation. Related molecules can purify the blood, so as to achieve the purpose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C08J7/18A61M1/36A61M1/14
CPCA61M1/14A61M1/36B01J20/265C08J7/18
Inventor 李永桂胡家亮杨正根陈校园
Owner GUANGZHOU KONCEN BIOSCI
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