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Alveolar bone repair material and preparation method and application thereof

A technology for repairing materials and alveolar bone, which is applied in the field of alveolar bone repairing materials and its preparation, and medical materials for alveolar bone repairing. The effect of forming, accelerating alveolar bone repair, and increasing bone mass

Active Publication Date: 2017-12-15
QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the guided tissue regeneration membrane is expensive, which significantly increases the medical expenses of patients.

Method used

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  • Alveolar bone repair material and preparation method and application thereof
  • Alveolar bone repair material and preparation method and application thereof
  • Alveolar bone repair material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Evaluation of the promoting effect of amino sugar on osteoblast growth

[0023] Prepare 100ml of 0.05% (w / v, the same below) chondroitin sulfate aqueous solution, 100ml of 0.05% carboxymethyl chitosan oligosaccharide aqueous solution, and 100ml of 0.05% N-acetylglucosamine aqueous solution, sterilize with moist heat, and set aside. Take the concentration as 2.0×10 4 200 µl of single cell suspension of osteoblast cell line MC3T3-e1 per ml, in a 96-well cell culture plate for routine cell culture in α-MEM medium containing 10% fetal bovine serum for 24 hours, then discard the original culture medium , with the culture medium as the control, the effects of sterile chondroitin sulfate aqueous solution, carboxymethyl chitosan oligosaccharide aqueous solution, and acetylglucosamine aqueous solution with concentrations of 100, 250, and 500 μg / ml on the growth of osteoblasts were respectively tested. The cells were incubated for 48 h, and the absorbance value at 490...

Embodiment 2

[0027] Example 2: Evaluation of the promotion effect of metal salts on osteoblast growth

[0028] Prepare 100ml of 0.05% (w / v, the same below) calcium chloride aqueous solution, 100ml of 0.05% zinc chloride aqueous solution, 100ml of 0.05% magnesium chloride aqueous solution, and 100ml of 0.01% strontium chloride aqueous solution, sterilize with moist heat, and set aside. Take the concentration as 2.0×10 4200 µl of single cell suspension of osteoblast cell line MC3T3-e1 per ml, in a 96-well cell culture plate for routine cell culture in α-MEM medium containing 10% fetal bovine serum for 24 hours, then discard the original culture medium , with the culture medium as the control, the effects of sterile calcium chloride aqueous solution, zinc chloride aqueous solution, and magnesium chloride aqueous solution with concentrations of 10, 50, and 100 µg / ml on the growth of osteoblasts were tested, and the concentration of 10, 25, and 50 µg / ml Effect of sterile strontium chloride sol...

Embodiment 3

[0032] Example 3: Evaluation of the promoting effect of amino sugar-metal salt complex on osteoblast growth

[0033] Prepare 0.1% chondroitin sulfate aqueous solution 100ml, 0.1% carboxymethyl chitosan oligosaccharide aqueous solution 100ml, 0.1% zinc chloride aqueous solution 100ml, 0.1% magnesium chloride aqueous solution 100ml, 0.02% strontium chloride aqueous solution 100ml; take 50ml Chondroitin sulfate solution, add 5ml of zinc chloride solution dropwise under stirring, add water to 100ml, stir and mix to obtain chondroitin zinc solution, wherein the concentration of chondroitin sulfate is 0.05% (w / v, the same below), chondroitin sulfate The ratio of the number of parts by mass to zinc chloride is 100:10; then take 50ml of chondroitin sulfate solution, add dropwise 10ml of magnesium chloride solution and 0.5ml of strontium chloride solution under stirring, add water to 100ml, stir and mix to obtain chondroitin Magnesium strontium solution, wherein the concentration of ch...

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Abstract

The invention discloses an alveolar bone repair material and a preparation method and application thereof. The alveolar bone repair material is a powdery, granular or massive composite formed by bone meal, metal salt and amino sugar, wherein the mass part ratio of bone meal, metal salt and amino sugar is 10:(0.01-20):(0.1-100). The composite adopts a multi-layered structure taking bone meal as the core, and comprises bone meal, metal salt, amino sugar and metal salt from the inside out. Bone meal, calcium, zinc, magnesium, manganese, strontium metal element, glycosaminoglycan, amino-oligosaccharide and amino-monosaccharide all have bone guiding and promoting functions. Therefore, the alveolar bone repair material has better bone guiding and promoting functions, and can serve as a bone filler in alveolar bone repair and bone defect repair to quicken formation of new bones, to increase bone weight and to promote bone defect repair.

Description

technical field [0001] The invention relates to a medical material for alveolar bone repair, in particular to an alveolar bone repair material compounded with bone powder and amino sugar, a preparation method and application thereof, and belongs to the field of biomedical materials. Background technique [0002] The alveolar bone defect caused by periodontal disease is a common disease in oral diseases. The alveolar bone defect causes the patient's teeth to loosen, fall off, and lose teeth, which seriously affects the quality of life of the patient. Dental implant restoration after tooth loss is a relatively advanced restoration method at present, but insufficient alveolar bone in the implant area, and the reduction in alveolar bone width and height caused by continuous alveolar bone resorption caused by inflammation and other etiologies, both It will affect the effect of implant restoration and become a common problem faced by dental implants. Therefore, it is necessary to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/02A61L27/12A61L27/20
CPCA61L27/02A61L27/12A61L27/20A61L27/3608A61L27/3645A61L27/365A61L2430/02A61L2430/12
Inventor 刘万顺
Owner QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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