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Preparation method of medical fiber wound dressing prepared through composition of natural polysaccharide derivatives and natural polymers

A technology of natural polymers and natural polysaccharides, which is applied in the field of preparation of natural polysaccharide derivatives/natural polymer composite fiber medical wound dressings, can solve problems such as not being able to meet the needs of skin tissue repair, and achieve excellent biodegradability and strength. control, excellent biocompatibility

Inactive Publication Date: 2017-12-15
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, single-component dressings are far from meeting the needs of skin tissue repair, so it is urgent to develop a dressing made of composite materials to meet related needs

Method used

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  • Preparation method of medical fiber wound dressing prepared through composition of natural polysaccharide derivatives and natural polymers
  • Preparation method of medical fiber wound dressing prepared through composition of natural polysaccharide derivatives and natural polymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Under the protection of nitrogen at 85°C, dissolve 3.0g dextran (molecular weight: 40,000) in 8wt% LiCl / DMF solution. After complete dissolution, the solution temperature drops to 55°C, add 5.6g pyridine, and stir for 40min. Add 8.6 g of methacrylic anhydride dropwise, react for 5 hours, cool down to room temperature after the reaction, precipitate in cold isopropanol, centrifuge, and vacuum dry to obtain modified dextran derivatives.

[0028] 2) Take 0.5g of the modified dextran derivative obtained in step 1), 0.5g of gelatin, 2g of deionized water, 1.1×10 -3 gDarocur 2959, fully carry out magnetic stirring at 40°C, and put the solution under ultrasonication for 1-2 hours to precipitate all the bubbles to obtain a uniform and transparent electrospinning solution.

[0029] 3) Take the electrospinning solution prepared in step 2), and use a multi-nozzle electrospinning machine to perform large-area electrospinning to obtain composite fibers of dextran derivatives and ...

Embodiment 2

[0032]1) Under nitrogen protection at 60°C, dissolve 3.0g konjac glucomannan (molecular weight: 200,000) in 6wt% LiCl / DMF. After complete dissolution, the solution temperature drops to 40°C, add 8.5g pyridine, and stir for 20min , add 13.0 methacrylic anhydride dropwise, react for 24 hours, cool down to room temperature after the reaction, precipitate in cold isopropanol, centrifuge, and vacuum dry to obtain modified konjac glucomannan derivatives.

[0033] 2) Take 0.2g of the modified konjac glucomannan derivative obtained in step 1), 0.8g of hyaluronic acid, 3.0g of deionized water, 5.5×10 -4 g Darocur 2959, fully carry out magnetic stirring at 40°C, and place the solution for 1-2 hours in ultrasonic to make all the bubbles precipitate out to obtain a uniform and transparent electrospinning solution.

[0034] 3) Take the electrospinning solution prepared in step 2), and use a multi-nozzle electrospinning machine to perform large-area electrospinning to obtain composite fiber...

Embodiment 3

[0037] 1) Under nitrogen protection at 70°C, dissolve 3.0g inulin (molecular weight 6,200) in 5wt% LiCl / DMF. After complete dissolution, the solution temperature drops to 40°C, add 5.6g pyridine, stir for 30min, dropwise Add 8.6g of methacrylic anhydride, react for 12h, cool down to room temperature after the reaction, precipitate in cold isopropanol, centrifuge, and vacuum dry to obtain modified inulin derivatives.

[0038] 2) Take 0.4g of the modified inulin derivative obtained in step 1), 0.6g of carboxymethyl cellulose, 3g of deionized water, 1.1×10 -3 g Quantacure QTX, fully carry out magnetic stirring at 40°C, and place the solution for 1-2 hours in ultrasonic to make all the bubbles precipitate out to obtain a uniform and transparent electrospinning solution.

[0039] 3) Take the electrospinning solution prepared in step 2), and use a multi-nozzle electrospinning machine to perform large-area electrospinning to obtain composite fibers of inulin derivatives and carboxyme...

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Abstract

The invention provides a preparation method of medical fiber wound dressing prepared through composition of natural polysaccharide derivatives and natural polymers and belongs to the field of medical dressing preparation. The preparation method of the medical fiber wound dressing prepared through composition of the natural polysaccharide derivatives and the natural polymers comprises steps as follows: natural polysaccharides are chemically modified, the modified natural polysaccharide derivatives and natural polymers are composited, the modified natural polysaccharide derivatives are obtained, fibers are prepared with an electrostatic spinning technology, the composite fibers are subjected to a crosslinking reaction under the irradiation of an ultraviolet lamp, cobalt-60 gamma ray radiation sterilization, segmentation and packaging are performed, and the medical fiber wound dressing prepared through composition of the natural polysaccharide derivatives and the natural polymers is obtained. The medical wound dressing is prepared from natural and renewable raw materials, is rich in source, adopts a simple preparation process, can realize extensive production, is controllable in strength, safe, environment-friendly and good in breathability and biocompatibility and has the functions of stopping bleeding, diminishing inflammation, resisting allergy and the like.

Description

technical field [0001] The invention discloses a preparation method of a novel natural polysaccharide derivative / natural polymer composite fiber medical wound dressing, which belongs to the field of medical dressing manufacture. Background technique [0002] At present, there are more than 300 varieties of high-end new medical dressings, which can be roughly divided into four categories: high-end wet dressings (mainly including foam, hydrocolloid, transparent film, hydrogel, seaweed, and hydrated fiber), antibacterial dressings (mainly including Silver, zinc, iodine, natural product additives, antibacterial polymers, antibiotics), vacuum closure wound treatment VAC and nanofiber dressings. However, the current global high-end biomedical dressing market is mainly occupied by more than 30 companies in Europe and the United States, such as 3M, AcryMed, Kendall Healthcare, etc. The products of these companies are basically distributed in the Chinese market, and the prices are ex...

Claims

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Application Information

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IPC IPC(8): A61L15/22A61L15/42A61L15/44A61L15/64D06M10/00D01D5/00
CPCA61L15/225A61L15/42A61L15/44A61L15/64A61L2300/232A61L2300/236A61L2300/252A61L2300/41A61L2300/412A61L2400/04D01D5/003D06M10/001D06M10/008C08L5/02C08L89/00C08L5/08C08L5/04C08L1/286C08L5/00
Inventor 马贵平朱晓磊聂俊许艳婷李哲夫
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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