Traditional Chinese medicine composition with function of adjuvant improvement in kidney function of chronic kidney disease patient
A technology for chronic kidney disease and renal function, applied in drug combinations, medical preparations containing active ingredients, medical formulas, etc., can solve problems such as poor efficacy of western and traditional Chinese medicines
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[0023] Part I Experimental Research
[0024] 1. Purpose
[0025] Establish unilateral ureteral obstruction renal fibrosis rat model, observe Chinese medicine composition of the present invention to rat renal function, urine protein quantification, kidney pathology, epithelial cell-mesenchymal transition differentiation (hereinafter referred to as EMT) index, explore Chinese medicine combination of the present invention The mechanism of action of the substance.
[0026] 2. Experimental animals
[0027] 75 healthy, male, pure-line SD rats, SPF level, 7-8 weeks old, body weight 220-250g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number SCXK (Beijing) 2012-0001 .
[0028] Feeding feed: common feed.
[0029] Breeding environment: the barrier environment of the Experimental Animal Center of Jiangsu Academy of Traditional Chinese Medicine, clean level, and the temperature was maintained at 20±2. ℃ Rats drank water freely, and 12h (h m...
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