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Traditional Chinese medicine composition with function of adjuvant improvement in kidney function of chronic kidney disease patient

A technology for chronic kidney disease and renal function, applied in drug combinations, medical preparations containing active ingredients, medical formulas, etc., can solve problems such as poor efficacy of western and traditional Chinese medicines

Active Publication Date: 2017-12-08
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] It solves the technical problem of poor curative effect of western medicine and traditional Chinese medicine used in the treatment of chronic kidney disease at the present stage. On the basis of the original traditional treatment, the traditional Chinese medicine composition of the present invention is added to help improve the renal function of patients with chronic kidney disease

Method used

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  • Traditional Chinese medicine composition with function of adjuvant improvement in kidney function of chronic kidney disease patient
  • Traditional Chinese medicine composition with function of adjuvant improvement in kidney function of chronic kidney disease patient
  • Traditional Chinese medicine composition with function of adjuvant improvement in kidney function of chronic kidney disease patient

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Embodiment Construction

[0023] Part I Experimental Research

[0024] 1. Purpose

[0025] Establish unilateral ureteral obstruction renal fibrosis rat model, observe Chinese medicine composition of the present invention to rat renal function, urine protein quantification, kidney pathology, epithelial cell-mesenchymal transition differentiation (hereinafter referred to as EMT) index, explore Chinese medicine combination of the present invention The mechanism of action of the substance.

[0026] 2. Experimental animals

[0027] 75 healthy, male, pure-line SD rats, SPF level, 7-8 weeks old, body weight 220-250g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number SCXK (Beijing) 2012-0001 .

[0028] Feeding feed: common feed.

[0029] Breeding environment: the barrier environment of the Experimental Animal Center of Jiangsu Academy of Traditional Chinese Medicine, clean level, and the temperature was maintained at 20±2. ℃ Rats drank water freely, and 12h (h m...

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Abstract

The invention belongs to the field of application of traditional Chinese medicines to adjuvant improvement in the treatment of a kidney function of a chronic kidney disease patient. Renal tubulointerstitial fibrosis is a common pathological process from CKD progress caused by various disease causes to end-stage renal failure, and the anti-renal fibrosis treatment becomes an important link of preventing and delaying the CKD progress. A traditional Chinese medicine composition with a function of adjuvant improvement in the kidney function of the chronic kidney disease patient consists of the following components in parts by weight: 200-600 parts of astragalus membranaceus, 200-600 parts of radix polygonum multiflorum preparata, 100-300 parts of prepared rhubarb, 100-300 parts of ligusticum wallichii, 10-120 parts of leech particles, 200-600 parts of charred fructus crataegi, 200-800 parts of exocarpium benincasae, 100-400 parts of peach kernels, 100-600 parts of centella asiatica and 100-300 parts of herba lycopi. In the formula, the astragalus membranaceus and the radix polygonum multiflorum preparata as monarchs have the efficacies of benefiting Qi and tonifying kidney; the leech particles as ministers have the efficacies of breaking glycogen storage disease, removing blood stasis, promoting blood circulation and prmoting diuresis through channel tunnels; the peach kernels, the ligusticum wallichii, theherba lycopi and the fructus crataegi have the efficacy of promoting blood circulation to remove blood stasis; the prepared rhubarb has the efficacy of dispelling caramelized, damp and turbid blood stasis; the exocarpium benincasae, the herba lycopi and the centella asiatica as adjuvant medicines have the efficacies of dissipating diuresis and dampness. Experiments and clinical trials show that the traditional Chinese medicine composition has the effect of adjuvant treatment on renal insufficiency.

Description

technical field [0001] The invention belongs to the application of traditional Chinese medicine in the field of treating kidney diseases, especially in the field of improving renal function of chronic kidney disease patients. Background technique [0002] Chronic kidney disease (hereinafter referred to as CKD) is chronic renal structure and dysfunction caused by various reasons (history of kidney damage is more than 3 months), or unexplained decrease in glomerular filtration rate (hereinafter referred to as GFR) (<60mL / min / 1.73m 2 ) more than 3 months of a group of chronic diseases, epidemiological data show that the incidence of CKD in my country is 10.8%, showing an upward trend. With the continuous progression of CKD, it can lead to end-stage renal failure, and the incidence rate is as high as one in 100,000. It seriously endangers human health and becomes a global public health problem. It is of great significance to prevent and treat CKD and delay renal failure. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P13/12A61K35/62
CPCA61K35/62A61K36/236A61K36/35A61K36/42A61K36/481A61K36/53A61K36/704A61K36/708A61K36/734A61K36/736A61K2300/00
Inventor 姚源璋谢圣芳
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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