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A traditional Chinese medicine composition for assisting in improving renal function in patients with chronic kidney disease

A technology for chronic kidney disease and renal function, applied in drug combinations, medical formulas, plant raw materials, etc., can solve the problems of poor curative effect of western medicine and traditional Chinese medicine

Active Publication Date: 2020-07-28
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0004] It solves the technical problem of poor curative effect of western medicine and traditional Chinese medicine used in the treatment of chronic kidney disease at the present stage. On the basis of the original traditional treatment, the traditional Chinese medicine composition of the present invention is added to help improve the renal function of patients with chronic kidney disease

Method used

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  • A traditional Chinese medicine composition for assisting in improving renal function in patients with chronic kidney disease
  • A traditional Chinese medicine composition for assisting in improving renal function in patients with chronic kidney disease
  • A traditional Chinese medicine composition for assisting in improving renal function in patients with chronic kidney disease

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Embodiment Construction

[0024] Part I Experimental Research

[0025] 1. Purpose

[0026] Establish unilateral ureteral obstruction renal fibrosis rat model, observe Chinese medicine composition of the present invention to rat renal function, urine protein quantification, kidney pathology, epithelial cell-mesenchymal transition differentiation (hereinafter referred to as EMT) index, explore Chinese medicine combination of the present invention The mechanism of action of the substance.

[0027] 2. Experimental animals

[0028] 75 healthy, male, pure-line SD rats, SPF level, 7-8 weeks old, body weight 220-250g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number SCXK (Beijing) 2012-0001 .

[0029] Feeding feed: common feed.

[0030] Breeding environment: the barrier environment of the Experimental Animal Center of Jiangsu Academy of Traditional Chinese Medicine, clean level, and the temperature was maintained at 20±2. ℃ Rats were free to drink water, and 12...

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Abstract

The invention belongs to the application field of traditional Chinese medicine in assisting the treatment of improving renal function of patients with chronic kidney disease. Tubulointerstitial fibrosis is a common pathological process that causes CKD to progress to end-stage renal failure caused by various etiologies. Anti-renal fibrosis therapy has become an important link to prevent and delay the progression of CKD. The traditional Chinese medicine composition for assisting in improving renal function of patients with chronic kidney disease of the present invention is composed of the following ingredients in weight ratio: 200-600 parts of astragalus, 200-600 parts of Polygonum multiflorum, 100-300 parts of rhubarb, and 100-300 parts of Ligusticum chuanxiong , 10‑120 parts of leech granules, 200‑600 parts of burnt hawthorn, 200‑800 parts of wax gourd skin, 100‑400 parts of peach kernel, 100‑600 parts of Luo De Da, and 100‑300 parts of Zeilan. In the prescription, Astragalus and Radix Shouwu benefit Qi and kidney as king; leech breaks disease accumulation, removes blood stasis, unblocks blood vessels, and sharpens meridians and tunnels as minister; peach kernel, Chuanxiong, Zelan, hawthorn promote blood circulation and remove blood stasis, rhubarb removes damp turbidity and blood stasis in lower Jiao, Winter melon rind, Zeilan, and Luode are used as adjuvant medicines to relieve water and turbidity. Both experiments and clinics show that the present invention has the effect of auxiliary treatment of renal insufficiency.

Description

technical field [0001] The invention belongs to the application of traditional Chinese medicine in the field of treating kidney diseases, especially in the field of improving renal function of chronic kidney disease patients. Background technique [0002] Chronic kidney disease (hereinafter referred to as CKD) is chronic renal structure and dysfunction caused by various reasons (history of kidney damage is more than 3 months), or unexplained decrease in glomerular filtration rate (hereinafter referred to as GFR) (<60mL / min / 1.73m 2 ) more than 3 months of a group of chronic diseases, epidemiological data show that the incidence of CKD in my country is 10.8%, showing an upward trend. With the continuous progression of CKD, it can lead to end-stage renal failure, and the incidence rate is as high as one in 100,000. It seriously endangers human health and becomes a global public health problem. It is of great significance to prevent and treat CKD and delay renal failure. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P13/12A61K35/62
CPCA61K35/62A61K36/236A61K36/35A61K36/42A61K36/481A61K36/53A61K36/704A61K36/708A61K36/734A61K36/736A61K2300/00
Inventor 姚源璋谢圣芳
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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