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Recombinant oxygen inhibition oriented transdermal drug delivery skin stubborn disease removing emulsion

A recombination and skin technology, applied in skin diseases, emulsion delivery, liquid delivery, etc., can solve the problems of skin irritation, easy recurrence, volatile precipitation of crystals, etc., to achieve fast treatment speed, wide application range, unique therapeutic effect

Inactive Publication Date: 2017-12-08
骆凌翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing medicines for treating skin have unsatisfactory therapeutic effects and are prone to relapse after healing, and the existing chemical medicines have problems such as high irritation to the skin, volatile crystallization, poor stability, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment provides a recombined oxygen-suppressing and directional drug penetrating skin stubborn disease one-wiping emulsion, which uses the following raw materials in parts by weight:

[0032] 1 part by weight of ketoconazole, 0.08 parts by weight of clobetasol propionate, 95 parts by weight of cream base, 45 parts by weight of hibiscus bark tincture, 2 parts by weight of benzoic acid, 45 parts by weight of salicylic acid, and 3 parts by weight of absolute ethanol parts, 6 parts by weight of gel matrix.

[0033] Wherein, the hibiscus bark tincture is prepared by the following method:

[0034] Take hibiscus bark, dry and pulverize it to obtain hibiscus bark fine powder; add 4 times the volume of ethanol (volume concentration is 80%) to the hibiscus bark fine powder, and carry out reflux extraction at 70°C for 6h, Obtain the extract and filter to obtain the hibiscus bark tincture.

[0035] The cream base is prepared by the following method: 5% stearic acid, 10% ...

Embodiment 2

[0042] This embodiment provides a recombined oxygen-suppressing and directional drug penetrating skin stubborn disease one-wiping emulsion, which uses the following raw materials in parts by weight:

[0043] 1.5 parts by weight of ketoconazole, 0.04 parts by weight of clobetasol propionate, 99 parts by weight of cream base, 30 parts by weight of hibiscus bark tincture, 4 parts by weight of benzoic acid, 30 parts by weight of salicylic acid, 6 parts by weight of absolute ethanol part, 3 parts by weight of gel matrix.

[0044] Wherein, the hibiscus bark tincture is prepared by the following method:

[0045]Take hibiscus bark, dry and pulverize it to obtain hibiscus bark fine powder; add 8 times the volume of ethanol (volume concentration is 75%) to the hibiscus bark fine powder, and carry out reflux extraction at 90° C. for 1 h, Obtain the extract and filter to obtain the hibiscus bark tincture.

[0046] The cream base is prepared by the following method: 10% stearic acid, 5% ...

Embodiment 3

[0053] This embodiment provides a recombined oxygen-suppressing and directional drug penetrating skin stubborn disease one-wiping emulsion, which uses the following raw materials in parts by weight:

[0054] 1.1 parts by weight of ketoconazole, 0.07 parts by weight of clobetasol propionate, 96 parts by weight of cream base, 42 parts by weight of hibiscus bark tincture, 2.5 parts by weight of benzoic acid, 42 parts by weight of salicylic acid, 4 parts by weight of absolute ethanol part, 5 parts by weight of gel matrix.

[0055] Wherein, the hibiscus bark tincture is prepared by the following method:

[0056] Take hibiscus bark, after drying and pulverizing, make hibiscus bark fine powder; add 6 times the volume of ethanol (volume concentration is 75%) to the hibiscus bark fine powder, carry out reflux extraction at 80°C for 4h, Obtain the extract and filter to obtain the hibiscus bark tincture.

[0057] The cream base is prepared by the following method: 8% stearic acid, 8% c...

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PUM

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Abstract

The invention relates to recombinant oxygen inhibition oriented transdermal drug delivery skin stubborn disease removing emulsion. External emulsion for treating skin diseases is prepared by adopting ketoconazole, clobetasol, a cream base, pseudolarice tincture, benzoic acid, salicylic acid, absolute ethanol and a gel substrate as raw materials and carrying out proper weight proportioning, all components in the external emulsion which is finally prepared and obtained realize a synergistic effect, and an oriented drug penetration force is formed; oxygen in air is blocked through glue sealing on the surface of disease skin, and germs die due to lack of oxygen supply; meanwhile, inward action of pharmaceutical effect is realized, and powerful sterilization is realized, so that inside and outside coordination can be realized, and all kinds of skin stubborn diseases can be rapidly and efficiently treated. The external emulsion disclosed by the invention has very good effect and curative effect in treating all kinds of tinea corporis, tinea of feet and hands, skin itch, tinea cruris and the like, and has specific curative effect on difficult disease, miscellaneous internal disease and stubborn disease of the skin diseases caused by multiple germ cross infection and unknown pathogeny.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an emulsion for external use for treating skin diseases and a preparation method thereof, in particular to a recombined oxygen-suppressing and directional drug penetrating skin stubborn disease one wipe away emulsion. Background technique [0002] The skin is the superficial tissue of the human body that prevents the infiltration of germs, promotes the exchange of nutrients between the human body and the outside world, and maintains the health of the human body. Healthy skin is not only the main symbol of life and health, but also the basic line of defense to prevent germs from penetrating, spreading, mutating and infecting the internal organs of the human body. People's mental health and so on have extensive and long-term meaning and effect. [0003] However, in modern society, due to the cross-influence of comprehensive factors such as the deterioration of the environment, the...

Claims

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Application Information

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IPC IPC(8): A61K36/15A61K9/10A61P17/00A61P31/10A61P17/04A61K31/496A61K31/573A61K31/192A61K31/60
CPCA61K9/0014A61K9/08A61K31/192A61K31/496A61K31/573A61K31/60A61K36/15A61K47/14A61K2236/333A61K2300/00
Inventor 骆凌翔
Owner 骆凌翔
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