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Ibuprofen imprinted composite membrane initiated by surface-grafted atom transfer radical polymerization and preparation method and application thereof

A technology of atom transfer and polymerization initiation, applied in the direction of separation methods, chemical instruments and methods, membranes, etc., to achieve the effect of repeated use times, not easy to destroy, and fast adsorption kinetic properties

Active Publication Date: 2017-12-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: 0.025-0.475mg·L was detected in surface water and drinking water in the UK -1 The commonly used detection methods for ibuprofen are mainly high performance liquid chromatography, gas chromatography, solid phase extraction, and solid phase microextraction, while the methods for detecting and separating and enriching ibuprofen using molecularly imprinted composite membranes are rarely reported.

Method used

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  • Ibuprofen imprinted composite membrane initiated by surface-grafted atom transfer radical polymerization and preparation method and application thereof
  • Ibuprofen imprinted composite membrane initiated by surface-grafted atom transfer radical polymerization and preparation method and application thereof
  • Ibuprofen imprinted composite membrane initiated by surface-grafted atom transfer radical polymerization and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of preparation method of the ibuprofen imprinted composite film that ATRP causes, concrete process is as follows:

[0035] (1) Synthesis of gold@polyaniline (Au@PANI) metal-organic nanocomposites

[0036] First, 0.75g of aniline and 1mL of HCl with a mass fraction of 36% were placed in 10mL of ethylene glycol solution and stirred evenly to obtain aniline solution; 0.165g of tetrachloroauric acid (HAuCl 4 ) was added to 15mL ethylene glycol solution, and stirred evenly to obtain HAuCl 4 solution; then, the 0.91g mass fraction is 30% hydrogen peroxide (H 2 o 2 ) was added to 15mL ethylene glycol solution, stirred evenly to obtain H 2 o 2 solution. The resulting aniline solution, HAuCl 4 solution, H 2 o 2 The solutions were cooled to 5°C, and under stirring conditions, the HAuCl 4 solution and H 2 o 2 The solution was added to the aniline solution at the same time, and the mouth of the reaction flask was sealed with paraffin, and the static reaction was c...

Embodiment 2

[0057] A kind of preparation method of the ibuprofen imprinted composite film that ATRP causes, concrete process is as follows:

[0058] (1) Synthesis of gold@polyaniline (Au@PANI) metal-organic nanocomposite, the synthesis method of Au@PANI nanocomposite is the same as that in Example 1.

[0059] (2) Synthesis of metal-organic (Br-Au@PANI) nanocomposites modified by ATRP initiator

[0060] First, add 4.5 mL of bromoisobutyryl bromide (2-BIB) to 15 mL of refined tetrahydrofuran, mix well and add to the dropping funnel for later use. Put 0.2 g of Au@PANI obtained in (1) into 100 mL of three-necked Add 30mL refined tetrahydrofuran and 4mL dry triethylamine (TEA) to a round-bottomed flask, shake at 0°C and blow nitrogen for 10min, add the above-mentioned 2-BIB tetrahydrofuran solution dropwise, and keep at 0°C for 2h , take out the flask, seal the flask with paraffin and continue to shake and react at 25°C for 24h. After the reaction, centrifuge at 10,000r / min, wash thoroughly w...

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Abstract

The invention relates to an ibuprofen imprinted composite membrane initiated by surface-grafted atom transfer radical polymerization and a preparation method and application thereof, and belongs to the technical field of the environmental material preparation. The preparation method comprises the following steps: using a nano-composite membrane as a base membrane, using ibuprofen as template molecules, using acrylamide (AM) as a functional monomer, and using ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, combining metal-organic nano-composite modification process, blending a metal-organic nano-compound (Br-Au-PANI) modified by a surface-grafted atom transfer radical polymerization (ATRP) initiator in the membrane material, and preparing the ibuprofen imprinted composite membrane by using an ATRP polymerization method. Through a static adsorption experiment, a preferential adsorption test and a differential permeability test, the ibuprofen imprinted composite membrane obtained by the preparation method is proved to have the higher adsorption capacity and excellent ibuprofen identification permeability.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and in particular relates to an ibuprofen imprinted composite film initiated by surface grafted atom transfer radical polymerization (ATRP) and a preparation method and application thereof. Background technique [0002] Since its inception, Molecular Imprinting Technology (MIT) has attracted great interest from scientists in the fields of materials science, life science, chemical engineering, and pharmacy. This technology has the following three characteristics: (i) high recognition similar to natural receptors; (ii) high stability compared with natural molecules; (iii) simple and easy preparation process with wide practicability. MIT is a technology that simulates the recognition of molecules such as enzymes and substrates, antibodies and antigens, hormones and receptors in nature, and prepares high-molecular imprinted polymers with specific selection and recognition characteristics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J7/12C08F259/08C08F220/56C08F222/14C08F2/44C08K9/12C08K3/08B01D71/76B01D69/12B01D69/02B01D15/38B01J20/26B01J20/28B01J20/30
CPCB01D15/3852B01D69/02B01D69/125B01D71/76B01D2325/12B01D2325/22B01J20/226B01J20/267B01J20/268B01J20/28033C08F2/44C08F259/08C08F2438/01C08J7/12C08J7/16C08J2327/16C08K3/08C08K9/12C08K2003/0831C08F222/102
Inventor 李荷吴秀玲
Owner GUANGDONG PHARMA UNIV
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