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Nattokinase composition and preparation method thereof

The technology of nattokinase and composition is applied in the field of nattokinase composition and its preparation, which can solve the problems of lack of effective substances of nattokinase, low activity of nattokinase, etc., and achieve the effect of preventing thrombolysis, inhibiting platelet aggregation, Ease of use

Active Publication Date: 2017-12-01
乐研新生物科技(成都)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are transgenic technology products, natto-extracted kinase, and natto-freeze-dried powder products appearing in the market. These products have technically disadvantages such as clinical safety, lack of effective substances other than nattokinase, and low activity of nattokinase. Nattokinase products with high vitality and complete nutrition are of great significance

Method used

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  • Nattokinase composition and preparation method thereof
  • Nattokinase composition and preparation method thereof
  • Nattokinase composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0033] The preparation method of nattokinase composition comprises the following steps:

[0034] (1) Put nattokinase, β-cyclodextrin, citric acid, and xylitol into the boiling granulator according to the ratio of raw materials in Table 1, and open the boiling granulator to fully prepare various raw and auxiliary materials in the boiling granulator. Mix for 8 minutes, then use water as the wetting agent for spray granulation, control the air inlet temperature to 85°C, and the outlet air temperature to 45°C, stop spraying and dry for 1 hour, and the moisture content of the particles is 3wt%;

[0035] (2) The prepared granules are sized with a 30-mesh sieve by a granulator.

[0036] Table 1: Raw material ratio and performance test results table of nattokinase composition

[0037]

[0038]

[0039] Find out by table 1, adopt the raw material proportioning of embodiment 2, embodiment 3, i.e. nattokinase is 9-11 weight part, and β-cyclodextrin is 84-86 weight part, and citric...

Embodiment 6-10

[0041] The preparation method of nattokinase composition comprises the following steps:

[0042] (1) Put nattokinase, β-cyclodextrin, citric acid, xylitol into the boiling granulator according to the raw material ratio of Table 2, open the boiling granulator and put various raw and auxiliary materials in the boiling granulator fully Mix for 8 minutes, then use water as the wetting agent for spray granulation, control the air inlet temperature to 85°C, and the outlet air temperature to 45°C, stop spraying and dry for 1 hour, and the moisture content of the particles is 3wt%;

[0043] (2) The prepared granules are sized with a 30-mesh sieve by a granulator.

[0044] Table 2: Raw material ratio and performance test results of nattokinase composition

[0045]

[0046]

[0047] Find out from Table 2, adopt the raw material ratio of embodiment 8, namely the performance of nattokinase composition is comparatively ideal when citric acid is 2.5 weight parts.

Embodiment 11-15

[0049] The preparation method of nattokinase composition comprises the following steps:

[0050] (1) Put nattokinase, β-cyclodextrin, citric acid, xylitol into the boiling granulator according to the raw material ratio of Table 3, open the boiling granulator and put various raw and auxiliary materials in the boiling granulator fully Mix for 8 minutes, then use water as the wetting agent for spray granulation, control the air inlet temperature to 85°C, and the outlet air temperature to 45°C, stop spraying and dry for 1 hour, and the moisture content of the particles is 3wt%;

[0051] (2) The prepared granules are sized with a 30-mesh sieve by a granulator.

[0052] Table 3: Raw material ratio and performance test results of nattokinase composition

[0053]

[0054]

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Abstract

The invention discloses a nattokinase composition and a preparation method of the nattokinase composition. The nattokinase composition is prepared from the following raw materials: nattokinase, dextrin, spice and sweeteners. According to the nattokinase composition and the preparation method of the nattokinase composition, intensive study is carried out on the ingredients of a prescription and the use amounts of the ingredients, then the suitable sweeteners and spice are optimized, and thus the good effects of preventing thrombus formation and dissolving thrombus are achieved; in addition, the preparation method is simple, the production cost is low, and thus the large-scale production is facilitated; the nattokinase can dissolve thrombus, resist coagulation, regulate blood pressure, reduce fat, improve blood circulation, stimulate the vascular endothelial cells to generate tissue-type plasminogen (t-PA), and activate the plasminogen to form plasmin, thus fibrous protein is dissolved, and thrombus is degraded; the nattokinase composition is mild and can continuously dissolve thrombus, and thus platelet aggregation is inhibited.

Description

technical field [0001] The invention relates to a nattokinase composition, in particular to a nattokinase composition and a preparation method thereof. Background technique [0002] Natto originated in ancient China and is a food made from soybeans fermented by Bacillus natto. During the Tang Dynasty, natto was introduced to Japan by Master Jianzhen. It first developed in temples, and gradually became popular among Japanese people, occupying an important position on the Japanese table. In the 1980s, Hiroyuki Sumi (必见洋行), who was engaged in thrombus research in the United States, used artificial thrombus plates to screen a large number of various natural products in order to find new antithrombotic substances. In an accidental attempt, he discovered that natto has a strong ability to dissolve artificial thrombus. After in-depth research, he finally isolated a serine protease capable of dissolving thrombus from the viscous substance of natto, and named it nattokinase . [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/16A61K47/26A61K47/12A61P7/02A61P9/00A61P9/12A61P3/04A61P7/00
CPCA61K9/1617A61K9/1623A61K38/482C12Y304/21062
Inventor 铃木理史余江
Owner 乐研新生物科技(成都)有限公司
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