Absorbable biomedical composite material and preparation method thereof

A composite material and biomedical technology, which is applied in the field of biomedical composite materials, can solve the problems of unfavorable application, damaged toughness of composite materials, and easy brittle fracture, etc., and achieve the effect of inhibiting the decline of strength, improving toughness, and alleviating microcracks

Active Publication Date: 2017-11-24
SHENZHEN CORLIBER SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this can largely contribute to the dispersion of hydroxyapatite and improve the interfacial force, improve the mechanical properties of the material, however, in the hydroxyapatite / polylactic acid composite material, due to the rigid hydroxyapatite particles There is no buffer mechanism with polylactic acid, which will easily lead to severe damage to the toughness of the composite material and brittle fracture, which is not conducive to its clinical application in orthopedics

Method used

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  • Absorbable biomedical composite material and preparation method thereof
  • Absorbable biomedical composite material and preparation method thereof
  • Absorbable biomedical composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Mix 0.1g of hydroxyapatite with a particle diameter of 5nm, 0.06g of L-lactide monomer and 0.06g of caprolactone monomer evenly, add 40ul of stannous octoate, then stir and heat to 180°C under nitrogen protection , after the reaction mixture melted evenly, the stirring reaction was continued for 2 hours to form a hydroxyapatite-rubber layer. Then, 10 g of L-lactide was added to the reaction system, and the reaction was continued at 180° C. for 2 hours.

[0081] After the reaction, the reaction mixture was dissolved in chloroform, then precipitated in methanol, and washed three times with methanol to obtain a hydroxyapatite-rubber layer-polylactic acid composite material.

[0082] The resulting hydroxyapatite-rubbery layer composite material and hydroxyapatite-rubbery layer-polylactic acid composite material were dissolved in chloroform respectively, and then centrifuged at a speed of 15000rpm, and the supernatant was precipitated in methanol and After cleaning, the fre...

Embodiment 2

[0089] Mix 1g of hydroxyapatite with a particle diameter of 200um, 0.4g of L-lactide monomer, 0.4g of p-dioxanone monomer and 0.4g of glycolide monomer in 100ml of dry toluene, add 160ul of octanoic acid Stinous, then stirred and heated to 80 degrees Celsius under the protection of argon, after the reactants were mixed and dissolved evenly, continued to stir and react for 48 hours to form a hydroxyapatite-rubber layer. Then, 8.5 g of glycolide was added to the reaction system, and the reaction was continued at 80 degrees Celsius for 48 hours.

[0090] After the reaction, the reaction mixture was precipitated in methanol and washed three times with methanol to obtain a hydroxyapatite-rubbery layer-polyglycolide composite material.

[0091] The obtained hydroxyapatite-rubbery layer composite material and hydroxyapatite-rubbery layer-polyglycolide composite material were respectively dissolved in chloroform, then centrifuged at a speed of 15000rpm, and the supernatant was taken i...

Embodiment 3

[0094]Mix 0.5g of hydroxyapatite with a particle diameter of 200nm and 0.3g of caprolactone monomer in 100ml of dry toluene, add 100ul of stannous octoate, then stir and heat to 120 degrees Celsius under the protection of argon, and wait until the reactants are mixed After dissolving evenly, continue to stir and react for 12 hours, then add 0.3 g of p-dioxanone monomer, and continue to react at 120 degrees Celsius for 12 hours to form a hydroxyapatite-rubber layer. Then add 4.6g of glycolide to the reaction system, continue to react at 130 degrees Celsius for 24 hours, then add 4.6g of L-lactide, continue to react at 130 degrees Celsius for 24 hours.

[0095] After the reaction, the reaction mixture was precipitated in methanol and washed three times with methanol to obtain a hydroxyapatite-rubber layer-polylactic acid glycolic acid composite material.

[0096] The obtained hydroxyapatite-rubbery layer composite material and hydroxyapatite-rubbery layer-polylactic acid glycoli...

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Abstract

The invention provides an absorbable biomedical composite material and a preparation method thereof. The absorbable biomedical composite material includes substrate particles, an intermediate layer and a polymer matrix, wherein the substrate particles include calcium-phosphorus-containing compounds; the intermediate layer is coated on the surfaces of the substrate particles and has a first glass transition temperature; the first glass transition temperature is not higher than a normal body temperature; the polymer matrix is formed on the outer surface of the intermediate layer and has a second glass transition temperature; and the second glass transition temperature is higher than the first glass transition temperature. According to the absorbable biomedical composite material disclosed by the invention, the absorbable biomedical composite material is capable of improving the mechanical strength and toughness.

Description

technical field [0001] The invention belongs to the field of biomedical composite materials, in particular to an absorbable biomedical composite material and a preparation method thereof. Background technique [0002] Human bones contain water, organic matter (bone glue), and inorganic salts. Among them, the inorganic salts are mainly composed of calcium and phosphorus compounds, which are distributed in the organic matter in the form of crystalline hydroxyapatite and amorphous calcium phosphate. Therefore, inorganic salts containing calcium and phosphorus compounds, especially hydroxyapatite, calcium phosphate, etc., are similar to the inorganic salt components of human bone, and have excellent biocompatibility and bioactivity. Biodegradable polyester materials, such as polylactic acid, polycaprolactone, polyglycolide, etc., have good biodegradability, biocompatibility and mechanical properties, and are common absorbable medical polymer materials. The application is more e...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/12A61L27/58A61L27/50
CPCA61L27/12A61L27/18A61L27/50A61L27/58A61L2430/02C08L67/04
Inventor 孙杨潘峰黄裕程向冬
Owner SHENZHEN CORLIBER SCI
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