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Preparation method for anti-corrosion zirconia/poly(lactic-co-glycolic acid) (PLGA) hybrid coating based on atomic layer deposition

An atomic layer deposition and glycolic acid technology, applied in coating, medical science, tissue regeneration, etc., can solve the problems of magnesium metal losing mechanical properties, failing to achieve clinical effects, unable to play a role in fixation and protection, etc. Controllable, simple method and high safety effect

Active Publication Date: 2017-11-21
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, American metal is relatively active, and the degradation rate in the body is too fast, so that the injured bone tissue has not been repaired, and the magnesium metal loses its inherent mechanical properties, and cannot play the role of fixation and protection. The hydrogen and -OH will affect the growth of surrounding tissue cells, and can not achieve a certain clinical effect. Therefore, modifying the surface of the metal to enhance its anti-corrosion performance in the early stage has great practical significance

Method used

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  • Preparation method for anti-corrosion zirconia/poly(lactic-co-glycolic acid) (PLGA) hybrid coating based on atomic layer deposition
  • Preparation method for anti-corrosion zirconia/poly(lactic-co-glycolic acid) (PLGA) hybrid coating based on atomic layer deposition
  • Preparation method for anti-corrosion zirconia/poly(lactic-co-glycolic acid) (PLGA) hybrid coating based on atomic layer deposition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] S1. The magnesium metal disc (16mm*16mm*5mm) is polished step by step with sandpaper as a substrate (the surface structure and topography is shown in figure 1 shown), then the substrate was ultrasonicated in ethanol and acetone for 30 min, and then dried naturally for later use;

[0026] S2. Perform atomic layer deposition on the dried substrate in step S1: specifically, heat the zirconium source to 150°C, then use 35°C deionized water as the O source, the deposition temperature is 250°C, and perform 100 cycles, and once The cycle consists of four (dimethylamino) zirconium pulses for 30ms, high-purity nitrogen cleaning for 20s, deionized water pulses for 150ms, and high-purity nitrogen cleaning for 20s; the substrate with zirconia coating on the surface can be obtained (the surface structure topography map like figure 2 shown);

[0027] S3, configure the PLGA (polylactic acid-glycolic acid copolymer) solution of 4% (w / v), and get 0.4ml dropwise on the material that s...

Embodiment 2

[0030] The difference from Example 1 is:

[0031] In step S2: the atomic layer deposition parameters are: the zirconium source is heated to 150°C, then 35°C deionized water is used as the O source, the deposition temperature is 250°C, 25 cycles are performed, and one cycle consists of tetrakis(dimethylamino)zirconium Pulse 30ms, high-purity nitrogen cleaning 20s, deionized water pulse 150ms, high-purity nitrogen cleaning 20s.

Embodiment 3

[0033] The difference from Example 1 is:

[0034] In step S2: the atomic layer deposition parameters are: the zirconium source is heated to 150°C, then 35°C deionized water is used as the O source, the deposition temperature is 200°C, 100 cycles are performed, and one cycle consists of tetrakis (dimethylamino) zirconium Pulse 30ms, high-purity nitrogen cleaning 20s, deionized water pulse 150ms, high-purity nitrogen cleaning 20s.

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Abstract

The invention provides a preparation method for an anti-corrosion zirconia / PLGA hybrid coating based on atomic layer deposition. The preparation method comprises the following steps: S1, with a magnesium metal disc as a substrate, carrying out ultrasonic treatment and natural air drying so as to obtain a treated substrate for subsequent usage; S2, subjecting the air-dried substrate obtained in the step S1 to atomic layer deposition so as to obtain a substrate containing a zirconia coating; and S3, preparing a PLGA solution, adding the prepared PLGA solution onto a substance obtained in the step S2 drop by drop and carrying out spin coating so as to obtain the anti-corrosion zirconia / PLGA hybrid coating on the surface of the substrate. The preparation method has the advantages that the hybrid coating integrates the characteristics of biocompatibility, wear resistance, corrosion resistance, crushing resistance, ossification performance, mechanical properties and low toxicity of zirconia and good biocompatibility, good biodegradability and no toxicity of PLGA together; the anti-corrosion hybrid coating is prepared on the surface of the substrate via an atom deposition process and a spin coating process sequentially; and the hybrid coating has high corrosion resistant due to synergism of zirconia and PLGA.

Description

technical field [0001] The invention relates to the technical field of application of nano-ceramic thin films and polymer hybrid thin films, in particular to a preparation method of a zirconia / polylactic acid-glycolic acid copolymer anti-corrosion hybrid coating based on atomic layer deposition. Background technique [0002] Biomedical materials such as stainless steel and titanium alloys are widely used due to their good mechanical properties and fracture toughness, which allow them to better maintain mechanical integrity and biocompatibility during bone tissue healing. However, certain metallic biomaterials, such as nickel-titanium alloys, release toxic ions during corrosion, which can cause allergic reactions. More importantly, these conventional biometallic materials do not degrade in physiological environments, which may require a follow-up surgery to remove the implant material after the bone has healed. This not only increases the patient's misery but also increases ...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/34A61L27/50A61L27/04
CPCA61L27/047A61L27/306A61L27/34A61L27/50A61L2300/604A61L2420/02A61L2430/02C08L67/04
Inventor 吴水林杨秋月刘想梅
Owner HUBEI UNIV
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