Method for catalytic conversion of cyano group into deuterated methyl, prepared aromatic deuterated methyl compound and application of compound

Abstract

The invention provides a method for catalytic conversion of a cyano group into deuterated methyl, a prepared aromatic deuterated methyl compound and an application of the compound. The method comprises the steps as follows: an aromatic cyano compound reacts to produce the aromatic deuterated methyl compound under the action of a metal catalyst with deuterium gas serving as a deuterium source. The cyano group is directly catalyzed into deuterated methyl with the deuterium gas serving as the deuterium source, the operation is simple, the raw material is cheap and easy to obtain, the reaction yield is high, the product deuteration rate is high, and the method can be applied to mass production. The prepared aromatic deuterated methyl compound can be used as a deuterated medicine or can be used for preparation of a deuterated medicine or deuterated medicine composition, and the pharmacokinetics, pharmacodynamics or metabolism toxicity of the medicine can be reduced while the medicine molecular activity is kept unchanged basically.

Description

technical field [0001] The invention belongs to the technical field of compound synthesis, and relates to a method for converting a cyano group into a deuterated methyl group through catalysis, an aromatic deuterated methyl compound prepared therefrom and an application thereof. Background technique [0002] Deuterium is a stable isotope of hydrogen, its relative atomic mass is twice that of hydrogen, and in general, deuterium has very low toxicity. Due to the nature of deuterium, the carbon-deuterium bond (C-D) in the compound has a lower vibrational zero-point energy than the carbon-hydrogen bond (C-H) and is more stable. Therefore, in drugs, part of the hydrogen atoms are replaced by deuterium atoms, so as to maintain the activity of the drug molecule basically unchanged, improve the pharmacokinetics and pharmacodynamics of the drug or reduce the metabolic toxicity of the drug. [0003] At present, the common deuterated drugs are to replace part of the methyl groups in t...

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Problems solved by technology

Synthesis, 1980, 10, 802-803 reported that under hydrogen pressure, nickel / alumina as a catalyst can directly convert cyano groups into methyl groups, but this method requires very high temperatures to achieve

There are also some methods for converting cyano groups into methyl groups, but the source of hydrogen does not originate from hydrogen. As Chem Ber, 99,227,1966 reported that cyano groups were directly converted into methyl groups under the catalysis of 10% Pd / C, but Its hydrogen source is a kind of iron compound, unless there is a deuterated iron compound as a deuterium source, otherwise such a method cannot be applied to the synthesis of deuterated methyl

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