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Traditional Chinese medicine topical gel and preparation method thereof

A technology of gel for external use and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve problems such as poor compatibility, increase the stability of preparations, and shorten swelling. Effect of time, optimal pharmacodynamic effect

Active Publication Date: 2017-11-07
广州中医药大学附属骨伤科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the formula of Wentong ointment also contains volatile oil components of traditional Chinese medicine, and these volatile oil components have poor compatibility with the water-based gel matrix, so it is necessary to further improve this deficiency

Method used

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  • Traditional Chinese medicine topical gel and preparation method thereof
  • Traditional Chinese medicine topical gel and preparation method thereof
  • Traditional Chinese medicine topical gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Formula:

[0030]

[0031] 2. The original preparation method of Wentong ointment

[0032] (1) The above twenty-two flavors, except menthol, borneol, camphor balls, methyl salicylate, and turpentine, and the other seventeen flavors such as psoralen, were extracted twice with 70% ethanol under reflux, each time for 2 hours, and combined The extract is filtered, and the filtrate is concentrated to a clear paste with a relative density of 0.85-0.95 (60°C);

[0033] (2) Take 960g of carbomer, add 18400mL of water to soak for 24h, add clear paste and continue to soak for 24h, mix well, add 500g of triethanolamine to dissolve, polysorbate-80 1600g, mix well;

[0034] Add menthol, borneol, camphor, methyl salicylate, turpentine and 500 g of laurocaprazine to dissolve, mix well, pack separately, and make 1000 sticks to obtain.

[0035] 3. A new process is used to prepare Wentong ointment emulsion-type gel, including the following steps:

[0036] (1) The above twenty-tw...

Embodiment 2

[0041] Optimization of extraction process

[0042] (1) Evaluation criteria: content of psoralen and isopsoralen, yield of dry paste, weighted comprehensive score.

[0043] Determination method of psoralen and isopsoralen content:

[0044] Chromatographic conditions:

[0045] Chromatographic column: InertsilODS-SPC18 column (150mm×4.6mm, 5μm); mobile phase: acetonitrile-0.02mol / L sodium dihydrogen phosphate solution (28:72); detection wavelength: 246nm; column temperature: 30°C; flow rate: 1.0 mL / min; take 10 μL of the test solution, and inject it for determination according to the above-mentioned high-performance liquid chromatography method.

[0046] Preparation of the test solution:

[0047] Preparation of the test solution: take the alcohol extract of Wentong ointment, put it in a separatory funnel, add n-hexane to extract 5 times, 15mL each time, combine the n-hexane solution, evaporate the solvent, add methanol to dissolve the residue and dilute it to a 10mL volumetric...

Embodiment 3

[0058] Embodiment 3 formulation process optimization

[0059] 1. The choice of glycerin dosage

[0060] Take 1.2 parts of carbomer, add 0 parts, 1.75 parts, 2.75 parts, 3.75 parts and 4.75 parts of glycerin respectively, and then add 24 mL of water to swell, and investigate the effect of glycerin dosage on the swelling time of carbomer. The experimental results are shown in Table 2.

[0061] Table 2 The effect of glycerin dosage on the swelling time of carbomer

[0062] Glycerin dosage (parts)

[0063] The experimental results show that the addition of glycerin can wet the carbomer and shorten the swelling time. When the amount of glycerin is 1.75 parts, glycerin and carbomer are just mixed until the carbomer is no longer dusty; when the amount of glycerin is 3.75 parts, glycerin and carbomer can be mixed evenly; If the pom clusters are too large, the swelling time will be longer. Therefore, adding an appropriate amount of glycerin to the new process can significa...

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Abstract

The invention relates to a preparation method of traditional Chinese medicine topical gel. The method comprises the following steps: taking fructus psoraleae, radix aconiti carmichaeli, fructus cnidii, radix dipsaci, fructus rubi, benzoin, rhizoma zingiberis, chilli, radix polygalae, rhizoma cibotii, radix aconiti, radix angelicae sinensis, rhizoma seu radix notopterygii, radix angelicae pubescentis, rhizoma galangae, rhizoma arisaematis and flos caryophyllata, adding ethanol for heating reflux extraction, combining extracting solutions, filtering and concentrating into clear paste; take carbomer, adding glycerin, and adding water to obtain a carbomer swelling solution; then adding the clear paste, soaking, mixing uniformly, and then adding triethanolamine to obtain carbomer aqueous gel containing alcohol extracts; dissolving albolene in turpentine and methyl salicylate, and adding menthol, borneol, camphor and laurocapram for dissolving, and then adding Tween-80 to obtain an oily matrix mixture; adding the mixture into the carbopol aqueous gel containing alcohol extracts, and emulsifying uniformly, so as to obtain the traditional Chinese medicine topical gel. The Wentong ointment obtained by the preparation method disclosed by the invention has better efficacy of being analgesic and detumescent and removing stasis than that of the Wentong ointment obtained through the original technology.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a gel for external use of traditional Chinese medicine and a preparation method thereof. Background technique [0002] Traditional Chinese medicine gel refers to a semi-solid or thick liquid preparation with gel properties made of Chinese medicine extracts and an appropriate amount of matrix. Among them, water-based gels have developed rapidly as external preparations of traditional Chinese medicines due to their good skin affinity. Commonly used water-based substrates mainly include carbomer, cellulose derivatives, alginate, tragacanth, acrylic resin, polyvinyl alcohol, chitosan, etc. The common preparation technology of gel is relatively simple. For example, if carbomer is used as the gel matrix, generally the carbomer is fully swelled with water first, and then alkaline substances such as triethanolamine or sodium hydroxide are added under stirring to ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/9068A61K47/32A61K47/10A61K47/06A61K47/44A61P29/00
CPCA61K9/0014A61K9/06A61K36/12A61K36/185A61K36/232A61K36/234A61K36/237A61K36/487A61K36/61A61K36/69A61K36/714A61K36/73A61K36/81A61K36/8884A61K36/9062A61K36/9068A61K47/06A61K47/10A61K47/32A61K47/44A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 谢华民吴涵袁伟彬
Owner 广州中医药大学附属骨伤科医院
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