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Bionic myocardial stent preparation method

A bionic and myocardial technology, applied in medical science, prosthesis, etc., can solve the problems of chemical substance residue release, reduce the mechanical strength of fabrics, etc., and achieve the effect of enhancing functional recovery, increasing adhesion, and good elasticity

Inactive Publication Date: 2017-11-03
常州帝君金属构件厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide an anti-wrinkle treatment method for real silk fabrics in view of the problems that the existing silk fabrics are easy to reduce the mechanical strength of the fabric after anti-wrinkle treatment, and there are residual chemical substances that release formaldehyde

Method used

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  • Bionic myocardial stent preparation method

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example 1

[0018] Take velvet antler and ball mill and pass through a 200-mesh sieve to get velvet antler powder. According to the mass ratio of 1:10, mix the velvet antler powder with 0.05mol / L, pH7.0 dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution, Homogenize at 800r / min for 2h, let it stand, and then centrifuge at 3500r / min for 10min, collect the supernatant and rotary evaporate to 1 / 5 of the original volume to prepare a concentrated gel solution; take scallop adductor muscle, According to the mass ratio of 1:5, mix the scallop adductor muscle with 0.05mol / L, pH7.0 disodium hydrogen phosphate-sodium dihydrogen phosphate solution, homogenize it in an ice-water bath at 0°C for 3 hours, and then let it stand for 1 hour , centrifuged at 3500r / min for 10min, collected the lower precipitate and vacuum freeze-dried to obtain adductor myofibrils; by volume ratio 1:10, mix 0.05mol / L sodium chloride solution with 0.05mol / L, pH7. 0 disodium hydrogen phosphate-sodium...

example 2

[0020] Take velvet antler and ball mill and pass through a 200-mesh sieve to get velvet antler powder. According to the mass ratio of 1:10, mix the velvet antler powder with 0.05mol / L, pH7.0 dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution, Homogenize at 950r / min for 3h, then centrifuge at 3750r / min for 12min after standing still, collect the supernatant and rotary evaporate to 1 / 5 of the original volume to prepare a concentrated gel solution; take scallop adductor muscle, According to the mass ratio of 1:5, mix the scallop adductor muscle with 0.05mol / L, pH7.0 disodium hydrogen phosphate-sodium dihydrogen phosphate solution, homogenize it in an ice-water bath at 2°C for 4 hours, and then let it stand for 2 hours , centrifuged at 3750r / min for 13min, collected the lower precipitate and vacuum freeze-dried to obtain adductor myofibrils; by volume ratio 1:10, mix 0.05mol / L sodium chloride solution with 0.05mol / L, pH7. 0 disodium hydrogen phosphate-so...

example 3

[0022]Take velvet antler and ball mill and pass through a 200-mesh sieve to get velvet antler powder. According to the mass ratio of 1:10, mix the velvet antler powder with 0.05mol / L, pH7.0 dipotassium hydrogen phosphate-potassium dihydrogen phosphate buffer solution, Homogenize at 1100r / min for 3h, then centrifuge at 4000r / min for 15min after standing still, collect the supernatant and rotary evaporate to 1 / 5 of the original volume to prepare a concentrated gel solution; take scallop adductor muscle, According to the mass ratio of 1:5, mix the scallop adductor muscle with 0.05mol / L, pH7.0 disodium hydrogen phosphate-sodium dihydrogen phosphate solution, homogenize it in an ice-water bath at 5°C for 5 hours, and then let it stand for 2 hours , centrifuged at 4000r / min for 15min, collected the lower precipitate and vacuum freeze-dried to obtain adductor myofibrils; mix 0.05mol / L sodium chloride solution with 0.05mol / L, pH7. 0 disodium hydrogen phosphate-sodium dihydrogen phosph...

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Abstract

The invention relates to a bionic myocardial stent preparation method, and belongs to the technical field of medical material preparation. According to the bionic myocardial stent preparation method, adductor muscles of scallops are extracted, and troponin of the adductor muscles are collected. Since phenolic hydroxyl groups in troponin molecules are capable of providing H-generated hydrogen bonds, and lone pair electrons existing in the troponin molecules are capable of receiving the H-generated hydrogen bonds, strong hydrogen bonds can be formed between the troponin molecules, adhesion between a prepared myocardial stent and myocardial fibers can be enhanced effectively, the myocardial stent will not depart from a myocardial infarction position due to high-speed and high-intensity heartbeats after being transplanted, and high elasticity, extensibility, stability, plasticity and certain mechanical strength of the bionic myocardial stent are realized, and meanwhile, the prepared bionic myocardial stent is high in biocompatibility, does not cause inflammatory response, toxic reaction and immunological rejection, and is self-degradable and harmless to human bodies.

Description

technical field [0001] The invention relates to a preparation method of a myocardial bionic support, which belongs to the technical field of medical material preparation. Background technique [0002] For example, the purpose of muscle tissue engineering is to achieve damage and repair of myocardium under the guidance of scaffolds that can simulate in vivo cardiac muscle tissue, cells and biomaterials, or to perform drug screening in vitro to exclude possible cardiotoxic side effects Drug. Important factors in the design of biomimetic scaffolds include the selection of biomaterials and the fabrication process of scaffolds. In recent years, a variety of natural polymers (such as collagen, chitosan, fibrin, gelatin, etc.) and synthetic polymers (such as polycaprolactone, polydimethylsiloxane) have been used in myocardial tissue engineering. The physical properties (such as spatial structure, mechanical properties, porosity, etc.) and chemical properties (such as hydrophilici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/58A61L27/50A61L27/22
Inventor 高俊季美
Owner 常州帝君金属构件厂
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