Tiamulin famarate soluble powder

A tiamulin fumarate soluble technology is applied in the field of tiamulin fumarate soluble powder, which can solve the problems affecting the drug compliance of animals, the granulation method is not suitable for use, and it is difficult to extrude and spheronize, so as to improve bioavailability degree, no bad taste, and the effect of improving the package and sex

Inactive Publication Date: 2017-11-03
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tiamulin fumarate has an unpleasant smell, which affects the compliance of animals to take medicine and brings great inconvenience to disease prevention and control
Commonly used soluble powders are more irritating. Some manufacturers use wet granulation technology to make them into granules in an attempt to reduce irritation. However, when the content of tiamulin fumarate is high, the viscosity of tiamulin fumarate is relatively high. Large, the prepared soft material is sticky, difficult to be extruded and rounded, and still has a certain pungent smell, so the conventional granulation method is not suitable for use

Method used

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  • Tiamulin famarate soluble powder
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A soluble tiamulin fumarate powder is prepared from the following raw materials in parts by weight: 60 parts of tiamulin fumarate, 20 parts of pullulan-polyglutamic acid cross-linked polymer, garlic polysaccharide solid dispersion 10 parts, 9 parts of soluble starch, 4 parts of sodium alginate, 3 parts of sodium tripolyphosphate, 1.6 parts of disodium edetate, and 0.3 parts of citric acid.

[0033] As described, the pullulan-polyglutamic acid cross-linked polymer is prepared by the following method: the pullulan solution is added dropwise to the polyglutamic acid solution at a rate of 5 drops / s, at 30°C Stir and react for 2 hours under the same conditions, precipitate the mixed solution with absolute ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 2 hours, and freeze-dry the dialysis retentate to obtain pullulan-polygu Amino Acid Crosslinked Polymer.

[0034] Described, th...

Embodiment 2

[0050] A soluble tiamulin fumarate powder is prepared from the following raw materials in parts by weight: 55 parts of tiamulin fumarate, 25 parts of pullulan-polyglutamic acid cross-linked polymer, garlic polysaccharide solid dispersion 13 parts, 7 parts of soluble starch, 5 parts of sodium alginate, 2.5 parts of sodium tripolyphosphate, 1.3 parts of disodium edetate, and 0.4 parts of citric acid.

[0051] As described, the pullulan-polyglutamic acid cross-linked polymer is prepared by the following method: the pullulan solution is added dropwise to the polyglutamic acid solution at a rate of 5 drops / s, at 30°C Stir and react for 2 hours under the same conditions, precipitate the mixed solution with absolute ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 2 hours, and freeze-dry the dialysis retentate to obtain pullulan-polygu Amino Acid Crosslinked Polymer.

[0052] Described, ...

Embodiment 3

[0068] A soluble tiamulin fumarate powder is prepared from the following raw materials in parts by weight: 50 parts of tiamulin fumarate, 30 parts of pullulan-polyglutamic acid cross-linked polymer, garlic polysaccharide solid dispersion 15 parts, 5 parts of soluble starch, 6 parts of sodium alginate, 2 parts of sodium tripolyphosphate, 1 part of disodium edetate, and 0.5 part of citric acid.

[0069] As described, the pullulan-polyglutamic acid cross-linked polymer is prepared by the following method: the pullulan solution is added dropwise to the polyglutamic acid solution at a rate of 5 drops / s, at 30°C Stir and react for 2 hours under the same conditions, precipitate the mixed solution with absolute ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 2 hours, and freeze-dry the dialysis retentate to obtain pullulan-polygu Amino Acid Crosslinked Polymer.

[0070] Described, the ma...

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Abstract

The invention discloses tiamulin famarate soluble powder which is prepared by the following raw materials in parts by weight: 50-60 parts of tiamulin famarate, 20-30 parts of a pullulan polysaccharide-polyglutamic acid cross-linked polymer, 10-15 parts of garlic polysaccharide solid dispersion, 5-9 parts of soluble starch, 4-6 parts of sodium alginate, 2-3 parts of sodium tripolyphosphate, 1-1.6 parts of disodium ethylenediaminetetraacetate and 0.3-0.5 part of citric acid. The tiamulin famarate soluble powder disclosed by the invention is uniform in particle size distribution, stronger in high temperature and high humidity resistance and good in stability. The tiamulin famarate soluble powder is simple and efficient in preparation process, recyclable in used ethanol solvent, mature in recycling process, energy-saving, environment-friendly, suitable for industrial production and wide in application prospect.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a soluble tiamulin fumarate powder. Background technique [0002] Tiamulin is also known as tiamulin, tiamulin, tiamulin, Zhiyuanjing, tiamulin, and tiamulin fumarate is mostly used in practice. Tiamulin is an animal-specific antibiotic. Its antibacterial effect is to inhibit the synthesis of susceptible bacterial proteins and act on the ribosomes in the bacteria. Tiamulin has special effects on a variety of Gram-positive bacteria and mycoplasma, especially on Staphylococcus aureus, streptococcus, various molds and some spirochetes. Tiamulin is used to prevent and treat diseases caused by mycoplasma infection, Escherichia coli, Salmonella, spirochete and other infections. It has special effects on swine mycoplasma pneumonia, Haemophilus pleuropneumonia, endemic pneumonia (asthma) and swine dysentery. It has good curative effect on mycoplasma arthritis, ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/22A61K47/69A61K47/36A61P31/04
CPCA61K9/146A61K31/22A61K47/36
Inventor 王统高
Owner 山东中牧兽药有限公司
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