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Giant salamander secretion hydrogel and its preparation method and application

A secretion and hydrogel technology, applied in the field of giant salamander secretion hydrogel and its preparation, can solve problems such as limitation and poor adhesion performance

Active Publication Date: 2020-01-17
武汉华联科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although the secretion of giant salamander extracted from the epidermis of giant salamander has certain adhesive properties in vitro, in water, the secretion of giant salamander has poor adhesive performance, which limits its use in aqueous environments such as wound adhesion in vivo. and other applications

Method used

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  • Giant salamander secretion hydrogel and its preparation method and application
  • Giant salamander secretion hydrogel and its preparation method and application
  • Giant salamander secretion hydrogel and its preparation method and application

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preparation example Construction

[0070] Also, see figure 2 , the preparation method of giant salamander secretion hydrogel according to one embodiment, comprising the following steps S110-S130.

[0071] S110. Add 1-10 parts of giant salamander secretion into the acidic solution and mix to form an emulsion, wherein the acidic solution contains 3-10 parts of acetic acid.

[0072] In one embodiment, the giant salamander secretion is prepared by the following method: scrape the giant salamander mucus from the outer surface of the adult giant salamander, then oxidize the giant salamander mucus in the air until the giant salamander mucus is white gel, and freeze-dry the oxidized giant salamander mucus Or vacuum dry. Specifically, freeze-drying can be carried out at -80°C to -20°C to obtain giant salamander secretions. Preliminary air oxidation can form a gel, and the giant salamander secretion obtained after freeze-drying or vacuum drying has good self-assembly ability, which further increases the viscosity of t...

Embodiment 1～5

[0089] Preparation of giant salamander secretion hydrogel

[0090] Dissolve acetic acid in a solvent with the mass in Table 1 to form an acidic solution. The giant salamander secretions were taken separately and added to the acidic solution, and mixed to form an emulsion. Take 0.5-5 parts of alginate and dissolve it in another part of solvent to prepare electrolyte solution. The emulsion is mixed with the electrolyte solution to obtain the giant salamander secretion hydrogel. Wherein, the alginate of embodiment 1 is sodium alginate, the alginate of embodiment 2 is potassium alginate, the alginate of embodiment 3 is sodium alginate and calcium alginate of 1:1, the alginate of embodiment 4 Alginate is 1:1 sodium alginate and potassium alginate. The alginate of embodiment 5 is sodium alginate. The solvent is all water.

[0091] Example Giant salamander secretion (g) Alginate (g) Acetic acid (g) Solvent (g) 1 5 1 6 88 2 1 0.5 3 70 3 10 ...

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Abstract

The invention discloses an andrias davidianus secretion hydrogel, and a preparation method and an application thereof. Raw materials of the andrias davidianus secretion hydrogel comprise andrias davidianus secretions, acetic acid or an acetic acid solution, an alginate, and a solvent. Acetic acid small molecules can break interchain and intrachain ionic complexation and hydrogen bonds of an andrias davidianus secretion protein, and when the alginate is added, a cross-linked network is formed in short time through ionic complexation of amino groups from the protein chains and carboxylic groups from the alginate, so that the andrias davidianus secretion hydrogel still having good adhesion property in water is obtained. The andrias davidianus secretion hydrogel also has good self-healing ability, and can be extensively used for biological adhesives and preparation of medicines for treating wounds.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a giant salamander secretion hydrogel and a preparation method and application thereof. Background technique [0002] Amphibians are exposed to a wide variety of environments, and their unique skin plays a key role in their physiological regulation. Their skin secretions are rich in bioactive substances and have been extensively explored as a great wealth of drug candidates for analgesia, antibiotics, wound healing, antidiabetic, antiviral, anticancer and cardiovascular treatments. However, to date, few studies have focused on the preparation of amphibian skin secretions for biomaterial applications, despite increasing research on their unique and intrinsic biological activities. [0003] The giant salamander, also known as the "Chinese giant salamander", belongs to the giant salamander family and is one of the largest extant amphibian species and a famous "living fossil", wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L89/00C08L5/04A61K35/65A61K9/06A61P17/02A61L24/00A61L24/08
CPCA61K9/06A61K35/65A61K47/36A61L24/0005A61L24/0031A61L24/08C08J3/075C08J2389/00C08J2405/04C08L89/00C08L5/04
Inventor 邢孟秋刘雨青商海涛魏泓蒋坤
Owner 武汉华联科生物技术有限公司
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