Sorbic acid-tea polyphenol composite nanoparticles and application thereof

Abstract

A sorbic acid-tea polyphenol composite nanoparticle and application thereof, the invention relates to the technical field of nanocomposite particle synthesis; its preparation method is as follows: 1. preparing composite nanoparticle; 2. detecting the encapsulation efficiency and Drug loading, the prepared composite nanoparticles have been tested for functional response performance, and qualified composite nanoparticles have been obtained; 3. Safety performance testing of composite nanoparticles: starting from the overall safety of composite nanoparticles, through the hemolytic test , In vitro cytotoxicity test and mouse acute toxicity test to study the in vitro and in vivo toxicity of composite nanoparticles, to initially understand the intensity and nature of their toxicity, and to obtain the dose-effect relationship; 4. Apply composite nanoparticles to the development of fresh-keeping health care. The safety performance of the composite nanoparticles is guaranteed, which provides an important guarantee for later application, and has a wide range of applications, providing a new application for the existing fresh-keeping health care field.

Description

technical field [0001] The invention relates to the technical field of synthesis of nanocomposite particles, in particular to a sorbic acid-tea polyphenol composite nanoparticle and its application. Background technique [0002] Nanocarriers (phytosterols, gelatin, chitosan, lycopene) have not only the characteristics of the drug itself, but also good adsorption properties, sustained release properties, dissolution properties and targeting properties due to their small molecule chemical characteristics. Loading functional products such as sorbic acid-tea polyphenols on the surface of nanocarriers can enhance the biological activity of the products and realize the targeted delivery of active substances. The project involves the controllable synthesis and modification of various nanocarriers, and screening out nanocarriers with strong loading capacity and good biocompatibility. [0003] Sorbic acid and its salts have a good inhibitory effect on the growth of mold and yeast, a...

AI Technical Summary

Problems solved by technology

However, the stability of tea polyphenol powder is poor, and it is easy to undergo reactions such as oxidation, polymerization, and condensation under conditions such as humidity, sunlight, and high temperature.

The bioavailability of catechins and other active substances in tea polyphenols is not high in the unprotected state. When taken directly as health care medicines, the structure of gastrointestinal digestion will be destroyed, affecting its health care effect