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A kind of chlorogenic acid purification and concentration method

A technology of chlorogenic acid and concentrated liquid, applied in chemical instruments and methods, separation/purification of carboxylic acid esters, organic chemistry, etc., can solve the problem of high energy consumption, reagents, solvents, inability to achieve continuous work, complicated process and other problems, to achieve the effect of high purification and concentration efficiency, high porosity and high retention rate

Active Publication Date: 2020-05-15
HANGZHOU RUINA MEMBRANE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above method also has some shortcomings: after the chlorogenic acid extract is obtained and filtered through an inorganic membrane, it is concentrated sequentially by rotary evaporation, filtration precipitation, and macroporous resin adsorption. The above method is not only complicated in process, but cannot be continuously Sexual work, the efficiency is low, and each process needs to consume a lot of heat energy, reagents, solvents, etc., the cost is high, and it is not environmentally friendly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for purifying and concentrating chlorogenic acid, comprising the following steps:

[0029] (1) Ultrafiltration treatment: pass the crude chlorogenic acid extract into a tubular ultrafiltration membrane (molecular weight cut-off of 100,000 Daltons) for ultrafiltration treatment.

[0030] (2) Diafiltration-re-ultrafiltration treatment: Ultrafiltration dilute liquid and ultrafiltration concentrated liquid are obtained after separation by tubular ultrafiltration membrane, the ultrafiltration dilute liquid is transferred to the fresh water tank, and the ultrafiltration concentrated liquid is transferred to the diafiltration tank, add water to the percolation tank, and the amount of water added is 1 times the volume of the dope to obtain leachate; the leachate is passed into the tubular ultrafiltration membrane for ultrafiltration treatment again, and the ultrafiltration leachate after ultrafiltration treatment The liquid is transferred to the fresh water tank, and t...

Embodiment 2

[0034] A method for purifying and concentrating chlorogenic acid, comprising the following steps:

[0035] (1) Ultrafiltration treatment: pass the crude chlorogenic acid extract into a tubular ultrafiltration membrane (molecular weight cut-off of 100,000 Daltons) for ultrafiltration treatment.

[0036] Wherein, the concentrated liquid surface of the tubular ultrafiltration membrane is also coated with a macroporous anti-clogging coating (thickness is 8 microns. The porosity is 75%, and the average pore diameter is 1.5 microns). The preparation method is as follows: The method prepares a 55wt% titanium dioxide colloidal solution, adds cellulose, [N-methyl perfluorohexanesulfonamido] ethyl methacrylate and a binder to the silica colloidal solution and stirs evenly to obtain a coating; Apply the paint on the concentrated liquid surface of the tubular ultrafiltration membrane, age at room temperature for 10 hours, and dry thoroughly to obtain a macroporous anti-clogging coating. ...

Embodiment 3

[0042] A method for purifying and concentrating chlorogenic acid, comprising the following steps:

[0043] (1) Ultrafiltration treatment: Pass the crude chlorogenic acid extract into a tubular ultrafiltration membrane (with a molecular weight cut-off of 90,000 Daltons) for ultrafiltration treatment.

[0044] Wherein, the thick liquid surface of the tubular ultrafiltration membrane is also coated with a macroporous anti-clogging coating (thickness is 5 microns. The porosity is 80%, and the average pore diameter is 0.5 microns). The preparation method is as follows: The method prepares a 50wt% titanium dioxide colloidal solution, adds cellulose, [N-methyl perfluorohexanesulfonamido] ethyl methacrylate and a binder to the silica colloidal solution and stirs evenly to obtain a coating; Apply the paint on the concentrated liquid surface of the tubular ultrafiltration membrane, age at room temperature for 8 hours, and dry thoroughly to obtain a macroporous anti-clogging coating. Th...

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Abstract

The invention relates to the field of purification of chlorogenic acid and discloses a chlorogenic acid purifying and concentrating method. The chlorogenic acid purifying and concentrating method comprises the following steps: (1) ultra-filtering a crude chlorogenic acid extract; (2) transferring an ultra-filtered thin solution to a fresh water tank, transferring an ultra-filtered concentrated solution to a percolation tank, adding water into the percolation tank to obtain a percolate; ultra-filtering the percolate again, transferring the ultra-filtered thin solution subjected to ultrafiltration again into the fresh water tank, and transferring the ultra-filtered concentrated solution subjected to ultrafiltration again to the percolation tank, and circulating in turn; and (3) conducting reverse osmosis treatment on the ultra-filtered thin solution, enabling a reverse osmosis thin solution to enter the fresh water tank again, and collecting a reverse osmosis concentrated solution. The method adopts the mode of combination of a tubular ultrafiltration membrane and a reverse osmosis membrane, the chlorogenic acid extract is purified and concentrated, on the basis of guaranteeing the purity of an obtained chlorogenic acid extract concentrated solution, the whole process is high in efficiency, the energy consumption is low, the cost is reduced, and no extra pollutants are produced in the whole process.

Description

technical field [0001] The invention relates to the field of chlorogenic acid purification, in particular to a method for purifying and concentrating chlorogenic acid. Background technique [0002] Chlorogenic acid is one of the main antibacterial and antiviral effective pharmacological components of honeysuckle. Chlorogenic acid has a wide range of antibacterial effects, but it can be inactivated by proteins in the body. Similar to caffeic acid, it can increase the central excitability of rats when taken orally or intraperitoneally. It can increase the intestinal motility of rats and mice and the tension of rat uterus. Choleretic effect, can enhance the secretion of bile in rats. It is sensitizing to humans, and after inhalation of plant dust containing this product, asthma and dermatitis may occur. [0003] The Chinese patent with the application number CN201310232265.X discloses a method for extracting high-purity chlorogenic acid, including raw material preparation a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/48C07C69/732B01D61/58
CPCB01D61/58C07C67/48C07C69/732Y02P20/10
Inventor 陈幸培陈健
Owner HANGZHOU RUINA MEMBRANE ENG
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