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Dimethylbiguanide gastric retention tablet and preparation method

A metformin and gastric retention technology, applied in the field of medicine, can solve problems such as not being able to meet the requirements of gastric retention time, achieve good market application value, and enrich the effect of product types

Active Publication Date: 2017-09-22
SHOUGUANG FUKANG PHARMA +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional metformin tablet is a single formula, which cannot meet the requirements of different gastric residence time

Method used

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  • Dimethylbiguanide gastric retention tablet and preparation method
  • Dimethylbiguanide gastric retention tablet and preparation method
  • Dimethylbiguanide gastric retention tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] 1. The floating and swelling synergistic formula contains Klucel (Hydroxypropylcellulose), polyethylene oxide (PEO 8000K), sodium carboxymethyl starch NaCMC 450cps, other ingredients (including coloring agent and magnesium stearate):

[0009] Formulations containing 500 mg of metformin:

[0010]

[0011] 2. Bioadhesive swelling synergistic formula contains chitosan, copovidone, polyoxyethylene polyethyleneoxide (PEO8000K), other ingredients (including coloring agent and magnesium stearate):

[0012] Formulations containing 500 mg of metformin:

[0013]

[0014]

[0015] A tablet preparation method: all excipients (hypromellose HPMC, hypromellose HPC, sodium carboxymethyl starch NaCMC, polyoxyethylene PEO 8000K, chitosan, copovidone, microcrystalline cellulose element) and magnesium stearate and carbonate, pass through No. 60 sieve respectively before tabletting, and then the mixture is compressed and molded with a German Fette tablet machine. The specific tab...

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Abstract

The invention discloses a floating and expanding collaborative type dimethylbiguanide gastric retention tablet containing 500 mg of dimethylbiguanide. The dimethylbiguanide gastric retention tablet is prepared from 500 mg of the dimethylbiguanide, hydroxypropyl cellulose, polyoxyethylene, sodium carboxymethyl starch, a coloring agent and magnesium stearate. Aiming at different gastric retention time, a formula is further defined; the product is regular and stable in drug release, and can meet medical requirements of different patient groups; moreover, the drug release in vivo is stable, a slow release effect is good, and a dosage form that the retention time of the floating preparation in stomach is extended and the bioavailability is improved is basically achieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a metformin gastric retention tablet and a preparation method thereof. Background technique [0002] Metformin has been in clinical use for more than 50 years since it came out in 1957. It is currently one of the most widely used oral glucose drugs in the world. The main diabetes guidelines at home and abroad all recommend that regardless of whether the patient is overweight or not, unless there is evidence or risk of renal damage, metformin should be used for treatment from the beginning, and metformin should be included in the combined treatment plan, which fully reflects the role of metformin in the treatment of diabetes. The "cornerstone" status in However, in clinical work, patients often encounter gastrointestinal discomfort such as diarrhea, nausea, vomiting, bloating, fatigue, and indigestion. A new option for patients. Traditional metformin tablets are a single for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/155A61K47/38A61K47/36A61P3/10
CPCA61K9/0002A61K9/0065A61K9/205A61K9/2059A61K9/2095A61K31/155
Inventor 张勇宋伟国方浩崔鑫李新建李法辉杨磊何英俊宋成刚杨大伟董良军高东圣杨春程
Owner SHOUGUANG FUKANG PHARMA
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