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Technology for extracting phosphoesterase by ion exchange resin

A technology of ion exchange resin and phosphatase, which is applied in the direction of enzyme, hydrolase, glycosylase, etc., can solve the problems of many times, long medication cycle, poor patient compliance, etc., achieve simple process, improve compliance, reduce The effect of product price

Inactive Publication Date: 2017-09-19
RUGAO YONGXING CASING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of taking immediate-release preparations is three times a day, and one course of treatment is 1-2 months. The medication cycle is long and the number of times is high, and the patient's compliance is relatively poor.

Method used

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  • Technology for extracting phosphoesterase by ion exchange resin
  • Technology for extracting phosphoesterase by ion exchange resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A kind of ion exchange resin extracts the component and the weight ratio of phosphatase process:

[0014]

[0015] A kind of preparation method of ion exchange resin extraction phosphatase process, concrete steps comprise:

[0016] ①Material preparation, preparation according to the weight ratio of each component of a compound phosphatase sustained-release tablet, the compound phosphatase is crushed at low temperature and passed through a 120-mesh sieve, and the pharmaceutical excipients are respectively crushed through a 80-mesh sieve.

[0017] ②Granulation, mix the components of the sustained-release tablet obtained in step ① evenly, and wet granulate; the process parameters are: the inlet air temperature is 40-45°C, the material temperature is 30-35°C, and the outlet air temperature is 22-26°C. ℃.

[0018] ③Sizing, crush the granules obtained in step ②, and pass through a 20-mesh sieve.

[0019] ④Compress the granules obtained in step ③ with a low-speed tablet p...

Embodiment 2

[0023] A kind of ion exchange resin extracts the component and the weight ratio of phosphatase process:

[0024]

[0025] A kind of preparation method of ion exchange resin extraction phosphatase process, concrete steps comprise:

[0026] ① Raw material preparation, according to the weight ratio of each component of a compound phosphatase sustained-release tablet, the compound phosphatase is ground at low temperature and passed through a 120-mesh sieve, and the pharmaceutical excipients are respectively crushed through a 80-mesh sieve.

[0027] ②Granulation, mix the components of the sustained-release tablet obtained in step ① evenly, and wet granulate; the process parameters are: the inlet air temperature is 40-45°C, the material temperature is 30-35°C, and the outlet air temperature is 22-26°C. ℃.

[0028] ③Sizing, crush the granules obtained in step ②, and pass through a 20-mesh sieve.

[0029] ④ Press the granules obtained in step ③ into tablets by a low-speed tablet ...

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Abstract

The invention discloses a technology for extracting phosphoesterase by ion exchange resin in the field of biological pharmacy. The phosphoesterase is prepared from the following ingredients in parts by weight: 3-35% of compound phosphoesterase, 20-55% of releasing agent and the balance of other medical ingredients. The preparation method for a sustained release tablet comprises the following steps that: preparing materials, pelletizing, carrying out size stabilization and tabletting. The sustained release tablet can realize a purpose that medicines can be slowly released in vivo for a long time, blood drug concentration is stable, and fluctuation is small so as to lower drug administration frequency and improve patient compliance. Through the control of the concentration of effective drug ingredients in blood, a drug effect can be conveniently maintained, a drug releasing peak receiving frequency is reduced, and certain protection is given to the visceral organs of a patient.

Description

technical field [0001] The invention relates to a process for extracting phosphatase with an ion exchange resin in the field of biopharmaceuticals. Background technique [0002] In recent years, with the changes in people's lifestyle and dietary structure, the incidence of hyperlipidemia fatty liver (non-alcoholic fatty liver) caused by obesity and other factors is increasing, and may develop into steatohepatitis, Fatty cirrhosis, currently there is no definite treatment. Barley malt root is a by-product of beer production, and compound phosphatase is a biologically active compound enzyme preparation extracted from it, mainly including phosphodiesterase, phosphatase, ribonuclease, deoxyribonuclease, Nucleotidase, proteolytic enzyme, arginine esterase, amylase and more than ten kinds of enzymes are brownish-yellow fine powder with a water content below 10%, and are better dissolved in a slightly alkaline solution. It has the functions of promoting appetite, enhancing physic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/54A61K9/22A61P1/16
CPCA61K38/54A61K9/0002A61K9/2054C12Y301/03C12Y301/03031C12Y301/04001C12Y302/01001C12Y302/01002
Inventor 费苹陈银芳费正明陈明全
Owner RUGAO YONGXING CASING
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