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Preparation method of medicine for treating hypertension

A technology for treating drugs and hypertension, which is applied in the field of preparing drugs for treating hypertension, can solve problems such as adverse reactions, instability of sustained-release system, etc., and achieves increasing compatibility, maintaining effective blood drug concentration, and increasing storage stability. Effect

Inactive Publication Date: 2016-07-20
张阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing sustained-release system of hypertension drugs is unstable and there are still adverse reactions. Therefore, it is necessary to develop a sustained-release tablet to prolong the release time of the drug. At the same time, it is necessary to be able to control the release of the drug and reduce adverse reactions.

Method used

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  • Preparation method of medicine for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] First, mix shell powder, organic microspheres, and polyvinyl alcohol with a mass ratio of 100:5:1 to make a green body; then remove organic matter by sintering at 900°C to form micropores, and ball mill it into powder to obtain a support material; weigh 0.2g Hydrochlorothiazide, 9.3g carbonate polymer, mixed uniformly according to the method of equal addition, then added 0.3g support material and 0.2g hydroxypropylcellulose propylene glycol solution with a mass concentration of 12%, granulated with a 30-mesh sieve, and dried at 60°C for 4h , after being sized through a 24-mesh sieve, mixed evenly, and compressed into tablets to obtain the drug.

Embodiment 2

[0023] First, mix shell powder, organic microspheres, and polyvinyl alcohol with a mass ratio of 100:4:1 to make a green body; then remove organic matter by sintering at 850°C to form micropores, and ball mill into powder to obtain a support material; weigh 0.3g Losartan, 9g carbonate polymer, mixed uniformly according to the method of equal addition, then add 0.6g support material and 0.1g mass concentration of 12% hydroxypropyl cellulose propylene glycol solution, granulate with 30 mesh sieve, dry at 60°C After 4 hours, 24-mesh sieve sieves the granules, mixes them evenly, and compresses them into tablets to complete.

Embodiment 3

[0025] First, mix shell powder, organic microspheres, and polyvinyl alcohol with a mass ratio of 100:4.5:1 to make a green body; then remove organic matter by sintering at 900°C to form micropores, and ball mill into powder to obtain a support material; weigh 0.3g Losartan, 9g carbonate polymer, mixed uniformly according to the method of equal addition, then add 0.6g support material and 0.1g mass concentration of 12% hydroxypropyl cellulose propylene glycol solution, granulate with 30 mesh sieve, dry at 60°C After 4 hours, 24-mesh sieve sieves the granules, mixes them evenly, and compresses them into tablets to complete.

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Abstract

The invention discloses a preparation method of a medicine for treating hypertension. The method comprises the following steps: firstly mixing shell powder, organic microspheres and polyvinyl alcohol to prepare a green body; sintering the green body into solid and carrying out ball-milling to form powder to obtain a support material; carrying out sealed reaction on equimolar 1,4-butanolide and 6-caprolactone in presence of an alcohol initiator and an organic zinc catalyst in a nitrogen environment; terminating the reaction with glacial acetic acid, carrying out precipitating in ice diethyl ether, filtering and vacuum-drying to obtain a carbonic ester polymer; weighing an active medicine and the carbonic ester polymer, mixing evenly, adding the support material and a hydroxy propyl cellulose alcohol solution, pelletizing through a 30-mesh sieve and drying the product at 60 DEG C for 4 hours; and granulating through a 24-mesh sieve, mixing evenly, and tabletting to obtain the medicine for treating hypertension. According to the medicine, a few of components are fused into a whole through a splicing system to form a stable system, so that release of the medicine is relatively well controlled.

Description

technical field [0001] The invention relates to a medicine preparation, in particular to a preparation method of a medicine for treating hypertension containing therapeutic ingredients. Background technique [0002] Oral absorption of general antihypertensive drugs is rapid, and most of them are absorbed through the gastrointestinal tract. Ordinary preparations reach peak concentration in 3.5 hours, half-life is 9 hours, and action time is 12 hours. Daily administration, and because hypertensive patients need long-term medication, it brings great inconvenience and pain to patients and their families. Hypertension refers to the clinical syndrome of systolic blood pressure>140mmHg and (or) diastolic blood pressure>90mmHg, excluding secondary factors. With the continuous development of social economy and the change of people's life style, the prevalence of hypertension in our country continues to increase. The prevalence of hypertension in adults in my country is 18.8%. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K45/00A61K31/549A61K31/4178A61K31/517A61K31/475A61K31/4168A61K47/46A61K47/32A61K47/34A61K47/38A61P9/12
CPCA61K45/00A61K9/0002A61K9/204A61K9/2054A61K9/2068A61K31/4168A61K31/4178A61K31/475A61K31/517A61K31/549
Inventor 张阳
Owner 张阳
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