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Fiber-based three-dimensional porous composite material for bone repair, its preparation method and molded product

A three-dimensional porous and composite material technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of not having a macroscopic three-dimensional structure, uneven distribution of internal fibers, and lack of mechanical support, etc., achieving low cost and easy molding , high security effect

Active Publication Date: 2020-04-07
MEDPRIN REGENERATIVE MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] In view of the lack of osteoinductivity of the current artificial bone filling materials, and the fact that the fibrous structure bone filling materials do not have a macroscopic three-dimensional structure, do not have mechanical support, or the internal fiber distribution is not uniform, and cannot meet the needs of bone defect parts for material performance, The present invention firstly provides a fiber-based three-dimensional porous composite material for bone repair, which has a macroscopic three-dimensional fiber structure. The characteristics of mechanical properties, at the same time have the role of bone conduction and mechanical support

Method used

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  • Fiber-based three-dimensional porous composite material for bone repair, its preparation method and molded product
  • Fiber-based three-dimensional porous composite material for bone repair, its preparation method and molded product
  • Fiber-based three-dimensional porous composite material for bone repair, its preparation method and molded product

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no. 1 approach

[0060] In the first embodiment of the present invention, a fiber-based three-dimensional porous composite material for bone repair is provided.

[0061] The composition of the fiber-based three-dimensional porous composite material includes micro-nano fiber powder and a binder, which are prepared by uniformly mixing the micro-nano fiber powder and the binder and undergoing a pore-forming process. in particular:

[0062]

[0063] The micro-nano fiber powder in the present invention means that the fiber raw material is pulverized and obtained with or without surface mineralization treatment.

[0064] The fiber raw material in the present invention can be various common fiber raw materials in this field. For example, it can be selected from synthetic polymer fibers, natural polymer fibers, and inorganic fibers, or a mixture of two or more fibers.

[0065] The synthetic polymer fibers of the present invention can be selected from artificially synthesized fibers that are degrad...

no. 2 approach

[0114] The second embodiment of the present invention provides a method for preparing a fiber-based three-dimensional porous composite material for bone repair. The method comprises the steps of:

[0115] Step 1: preparing fibers with a diameter of 0.1-100 μm by electrospinning, and then pulverizing the fibers by crushing technology to obtain micro-nano fiber powder with a particle size of 10-500 μm;

[0116] Step 2: the step of uniformly mixing the micronano fiber powder and the binder to obtain a mixed system;

[0117] Step 3: a step of subjecting the mixed system to a pore-forming process to obtain the fiber-based three-dimensional porous composite material;

[0118] The binder includes biodegradable and self-curable inorganic components; based on the total mass of the porous composite material, the content of the micro-nano fiber powder is 5-50% by mass.

[0119] Typically, the preparation method of the present invention can be carried out according to the following step...

no. 3 approach

[0134] In the third embodiment of the present invention, there is provided a molded product, which is the fiber-based three-dimensional porous composite material for bone repair according to the first embodiment or the fiber-based three-dimensional porous composite material for bone repair according to the second embodiment. Preparation method of fiber-based three-dimensional porous composite material for bone repair The obtained fiber-based three-dimensional porous composite material is obtained by molding.

[0135] The molded product of the present invention can typically be a medical biological repair material, more specifically, a human bone repair material.

[0136] Any desired product can be obtained through different molding processes. Furthermore, the third embodiment of the present invention provides a three-dimensional porous scaffold for human bone repair.

[0137] In such molded products, the presence of nanofibrous structure makes the scaffold have a significant e...

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Abstract

The invention provides a fiber-based three-dimensional porous composite material for bone repair and a preparation method thereof and a molded product. The fiber-based three-dimensional porous composite material comprises micronano fiber powder and a binder, wherein the particle diameter of the micronano fiber powder is 10-500 micrometers, the diameter of fiber forming the micronano fiber powder is 0.1-100 micrometers, and the micronano fiber powder is evenly dispersed in the binder; the binder comprises biodegradable and self-curable inorganic components; the fiber-based three-dimensional porous composite material comprises, by mass, 5-50% of the micronano fiber powder, the porosity of the fiber-based three-dimensional porous composite material is 30-85%, and the compressive strength is 1-15 MPa. A constructed fiber-based three-dimensional connected porous scaffold is simple in preparation method and has a micronano fiber structure, so that the scaffold has a remarkable induced osteogenesis effect; the constructed fiber-based three-dimensional connected porous scaffold can better meet the filling demand of bone defect sites and can provide better mechanical properties.

Description

technical field [0001] The present invention relates to a fiber-based porous composite material for bone repair and its preparation method, and molded products prepared by using the fiber-based porous composite material, in particular to a three-dimensional porous scaffold and its preparation method, belonging to the technical field of tissue engineering repair . Background technique [0002] At present, the number of fractures caused by work-related injuries and traffic accidents is gradually increasing, and the aging population also brings more diseases such as degenerative diseases of the spine and osteoporosis. Bone tumors, osteomyelitis, and hereditary bone diseases are also more common in clinical practice. orthopedic diseases. The self-healing ability of bone tissue is limited, and the bone defect cavity formed by most bone tissue diseases is difficult to heal. Surgical bone grafting is usually required to fill the defect to provide mechanical support and improve the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50A61L27/56
CPCA61L27/425A61L27/427A61L27/50A61L27/56A61L2430/02C08L67/04
Inventor 张婧袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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