Method for preparing high activity bone defect repairing material
A technology for repairing materials and bone defects, applied in the field of preparation of medical biomaterials, can solve the problems of difficult productization and inconvenient molding, and achieve the effect of easy processing and obvious effect.
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Embodiment 1
[0013] Example 1: Polyethylene glycol (average molecular weight 600) was mixed with lactide in a molar ratio of 1:30, polymerized at 200°C for 24 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the powder and BMP evenly at a ratio of 1000:5, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissues have no inflammation. After 12 weeks, the X-ray photos and Hard tissue sections showed good osteogenesis.
Embodiment 2
[0014] Example 2: Polyethylene glycol (average molecular weight 400) was mixed with lactide in a molar ratio of 1:20, polymerized at 160°C for 48 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the powder and BMP evenly at a ratio of 100:1, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissues have no inflammation. After 12 weeks, the X-ray photos and Hard tissue sections showed good osteogenesis.
Embodiment 3
[0015] Example 3: Glycerin and lactide were mixed at a molar ratio of 1:10, polymerized at 180°C for 36 hours to obtain polylactic acid, which was pulverized below 0°C into polylactic acid powder. At low temperature, mix the polylactic acid powder and BMP evenly at a ratio of 1000:2, press it into a certain shape below 38°C, and implant it into the bone defect site. After three weeks, the bone formation is obvious, and the surrounding tissue is basically free of inflammation. After 12 weeks, X-ray photos and hard tissue sections showed that the osteogenesis effect was good.
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