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A kind of preparation method of surface molecularly imprinted polymer applied in aqueous phase

A surface molecular imprinting and polymer technology, applied in chemical instruments and methods, and other chemical processes, can solve problems such as poor practicability, template molecule embedding, and large contact angle of materials, and achieve excellent results

Inactive Publication Date: 2018-12-25
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the technical defects of the existing molecularly imprinted polymer preparation method, such as severe embedding of template molecules, long processing time, large material contact angle, difficulty in using in water phase, and poor practicability, the present invention provides a surface molecule for water phase application. The preparation method of imprinted polymer aims to provide a molecularly imprinted polymer with large imprinting factor, fast adsorption and desorption speed, large adsorption capacity and good selectivity

Method used

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  • A kind of preparation method of surface molecularly imprinted polymer applied in aqueous phase
  • A kind of preparation method of surface molecularly imprinted polymer applied in aqueous phase
  • A kind of preparation method of surface molecularly imprinted polymer applied in aqueous phase

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Effect test

Embodiment 1

[0075] Example 1 Preparation of naringin surface molecularly imprinted polymer SMIPs

[0076] (1) Synthesis of metal-organic gel MOGs

[0077] Fe(NO 3 ) 3 9H 2 O and trimesic acid were dissolved in ethanol at a molar ratio of 3:2, and every mmol of Fe(NO 3 ) 3 9H 2 O was added with 7ml of ethanol, and 15ml of ethanol was added to every mmol of trimesic acid, and the two were fully mixed under vigorous stirring to obtain gel-like MOGs.

[0078] (2) Synthesis of macroporous carrier

[0079] Mix MOGs, glycidyl methacrylate (GMA), ethylene glycol dimethacrylate (EDMA) and azobisisobutyronitrile (AIBN), add GMA 0.4mmol, EDMA 0.27mmol, AIBN 0.8 per gram of MOGs mg. Under the protection of nitrogen, stir and react at 60°C for 24 hours, separate solid and liquid, wash repeatedly with 0.25mol / L sulfuric acid solution until no iron ions can be detected in the washing liquid, then wash with water and ethanol until the washing liquid has no UV absorption, and vacuum dry at 60°C ,...

Embodiment 2

[0086] Embodiment 2: Selective adsorption experiment

[0087] Take the aqueous solution of 20mg / ml naringin and the structural analog (pigenin and rutin) of naringin respectively as sample solution, under the same conditions, carry out adsorption with SMIPs and SNIPs prepared by embodiment 1 and blank control Experiments were carried out to measure the amount of adsorption and evaluate the recognition selectivity of SMIPs. Accurately weigh about 30mg of SMIPs and SNIPs and add them to two 10.00ml sample aqueous solutions (20mg / ml, pH 8.0), and shake at a constant temperature of 25°C for 10 minutes to carry out adsorption experiments. Solid-liquid separation, according to the change of sample concentration before and after adsorption, calculate Adsorption capacity.

[0088] The adsorption amounts of SMIPs and SNIPs for naringin were 6.49 μmol / g and 2.01 μmol / g, respectively, and the imprinting factor was 3.25; the adsorption amounts for apigenin were 0.041 μmol / g and 0.024 μmo...

Embodiment 3

[0089] Embodiment 3 adsorption kinetics experiment and desorption experiment

[0090] Take 10.00ml of naringin aqueous solution (20mg / ml) as sample solution, accurately weigh about 30mg of SMIPs (embodiment 1) to carry out adsorption experiment, take samples and analyze at different times, calculate the adsorption capacity, and obtain Figure 6 The adsorption kinetic curve shown in the figure evaluates the adsorption speed of SMIPs for template molecules. From Figure 6 It can be seen that SMIPs reached the adsorption equilibrium for naringin in about 3 minutes, indicating that the SMIPs prepared by the present invention have a very fast adsorption speed for template molecules and have excellent adsorption kinetic properties.

[0091] Take the above SMIPs whose adsorption has reached equilibrium for solid-liquid separation, add 10.00ml of acetic acid solution (pH3.0) to the solid and shake at a constant temperature of 25°C for 10 minutes for desorption experiment, separate so...

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Abstract

The invention discloses a preparation method of surface molecularly imprinted polymers in water phase application. The preparation method comprises the following steps: polymerizing solutions containing MOGs, glycidyl methacrylate, ethylene glycol dimethacrylate and an initiator, and subsequently conducting washing and drying to obtain a macroporous carrier; reacting the macroporous carrier with a photoinitiator, and conducting washing and drying to obtain the macroporous carrier with the photoinitiator on the surface; pre-assembling template molecules and functional monomers, then mixing the pre-assembled template molecules and functional monomers with a crosslinker and the treated macroporous carrier, conducting photopolymerization and washing, removing the template molecules, and conducting drying to obtain the surface molecularly imprinted polymer material, wherein the molar ratio of the functional monomers to the crosslinker is 1:(20-30). According to the preparation method, the macroporous material prepared by using the MOGs as a pore-foaming agent is used as the carrier and synergistically matched with the crosslinker with a high addition proportion, thereby preparing the surface molecularly imprinted polymers SMIPs with good template molecule identifying selectivity, large adsorption capacity and high adsorption and desorption speed.

Description

technical field [0001] The invention belongs to the field of molecularly imprinted materials, and in particular relates to a method for preparing a surface molecularly imprinted polymer that can be applied in an aqueous phase. Background technique [0002] Molecular Imprinted Polymers (MIPs) is a kind of biomimetic molecular recognition material that began to flourish in the 1950s. It is a highly cross-linked polymer prepared in the presence of template molecules (target molecules to be recognized). First, functional monomers and template molecules are pre-assembled to form complexes through covalent or non-covalent bonds, and then polymerization is initiated in the presence of a cross-linking agent, and finally template molecules are removed from the polymer. In a highly cross-linked polymer structure, The imprinted cavities that are complementary to the template molecule in terms of size, shape, and group distribution are left, that is, the imprinted site, which can then s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F267/06C08F222/14C08F2/48C08F222/32C08J9/26B01J20/26
CPCB01J20/268C08F2/48C08F220/32C08F220/325C08F267/06C08F2438/01C08J9/26C08J2201/0422C08J2333/14C08J2351/00C08F222/14
Inventor 王艳冯雪雪孙磊乌铁蕾钟世安
Owner CENT SOUTH UNIV
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