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PET/MRI bimodal photographic developer SPIO-NOTA-68Ga, and preparation method and application thereof

A technology of spio-nota-68ga and SPIO-PEG2000-NH2, applied in the medical field, can solve problems such as the advent of dual-modal imaging drugs, and achieve good in vitro stability and water solubility, mild conditions, and simple reaction steps.

Inactive Publication Date: 2017-08-04
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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Problems solved by technology

[0002] In the clinical diagnosis of tumors, positron emission tomography (PET) and magnetic resonance imaging (MRI) are playing an increasingly important role, but single-mode PET and MRI are both important in diagnosis. There are certain limitations, therefore, PET / MRI fusion technology has become an inevitable trend of current imaging technology
In 2011, PET / MRI scanners have entered the clinic, but so far there is no dual-modal imaging drug for clinical use

Method used

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  • PET/MRI bimodal photographic developer SPIO-NOTA-68Ga, and preparation method and application thereof
  • PET/MRI bimodal photographic developer SPIO-NOTA-68Ga, and preparation method and application thereof
  • PET/MRI bimodal photographic developer SPIO-NOTA-68Ga, and preparation method and application thereof

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Embodiment Construction

[0028] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings.

[0029] 1. Materials and methods

[0030] 1.1 Reagents and instruments

[0031] SPIO-PEG 2000 -NH 2 (1mg / ml, Nanjing Xianfeng Nano Material Technology Co., Ltd.), NOTA-NHS (French CHEMATECH company), dilute hydrochloric acid (12.5mol / L, German Merck) sodium acetate, glacial acetic acid, etc. (Shanghai Bailingwei Chemical Technology Co., Ltd. ), MEM culture solution, fetal bovine serum, 0.25% trypsin, PBS solution, etc. (Gibco, USA), normal Kunming mice, male, 18-22 g (Experimental Animal Center, Southern Medical University).

[0032] JEM-200CX Transmission Electron Microscope (Japan JEOL Company), NanoZS Nanoparticle Size Potentiometer (UK Malvern Company), Vibrating Sample Magnetometer VSM 7407 (US Lakeshore Company), IRAffinity-1 Fourier Tr...

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Abstract

The invention discloses a compound SPIO-NOTA-68Ga and a preparation method thereof. The preparation method comprises the steps of using a polyethylene glycol derivative (PEG2000) modified SPIO surface amidogen for coupling a bifunctional chelating agent 1,4,7-triazacyclononane-1,4,7-nitrilotriacetic (NOTA) into the nanometer surface so as to obtain a labelled precursor SPIO-PEG2000-NOTA; then adopting 68Ga for radiolabeling SPIO to obtain the SPIO-NOTA-68Ga. In addition, the invention discloses application of the SPIO-NOTA-68Ga. Through researching in-vitro and partial in-vivo biological properties, a result shows that the SPIO-NOTA-68Ga has favorable physicochemical property and biocompatibility, higher in-vitro stability, favorable water solubility, and high labeling rate, has no need to be purified, and can be applied in research of subsequent PET / MRI bimodal development when being used as a PET / MRI bimodal probe.

Description

technical field [0001] The present invention relates to PET / MRI dual mode imaging agent SPIO-NOTA- 68 Ga and its preparation method and application belong to the field of medicine. Background technique [0002] In the clinical diagnosis of tumors, positron emission tomography (PET) and magnetic resonance imaging (MRI) are playing an increasingly important role, but single-mode PET and MRI are both important in diagnosis. There are certain limitations, therefore, PET / MRI fusion technology has become an inevitable trend of current imaging technology. In 2011, PET / MRI scanners have entered clinical practice, but so far no dual-modality imaging drugs have been released for clinical use. Therefore, designing an effective dual-modality imaging drug has become an important research work. This paper reports the synthesis and preliminary properties of a new PET / MRI bimodal drug. [0003] Superparamagnetic iron oxide nanoparticles (SPION) are widely used in medical research due to...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/08A61K49/10A61K49/12A61K51/04A61K51/06
CPCA61K49/0002A61K49/085A61K49/106A61K49/128A61K51/0482A61K51/065
Inventor 尹吉林王欣璐吴凡
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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