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TcO nucleus marked ciprofloxacin dithiocarbamate complex and preparation method and applications thereof

A technology of ciprofloxacin and ammonium sulfate, applied in the fields of radiopharmaceutical chemistry and clinical nuclear medicine, can solve the problems of high uptake, low inflammation/muscle ratio, etc.

Inactive Publication Date: 2009-11-11
BEIJING NORMAL UNIVERSITY +1
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Problems solved by technology

and 99 Tc m -ciprofloxacin compared to 99 Tc m Although N-CPFXDTC has a high inflammation uptake and inflammation / blood ratio, its inflammation / muscle ratio is low, and its uptake in liver, lung and other organs is high, so it is still necessary to develop a more ideal new type of inflammation imaging agent

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  • TcO nucleus marked ciprofloxacin dithiocarbamate complex and preparation method and applications thereof
  • TcO nucleus marked ciprofloxacin dithiocarbamate complex and preparation method and applications thereof
  • TcO nucleus marked ciprofloxacin dithiocarbamate complex and preparation method and applications thereof

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Embodiment Construction

[0019] Describe the present invention in detail below by embodiment:

[0020] A sort of 99 Tc m O nuclear labeled ciprofloxacin dicarbaminate complex

[0021] 99 Tc m Preparation of O-CPFXDTC:

[0022] Add 1-5mL_Na to the GH kit 99 Tc m o 4 (37~740MBq), after shaking well and standing at room temperature for 15 minutes, you can get 99 Tc m -GH. Use 0.1mol / L NaOH to adjust the pH value of the solution to 8, add 1mL of CPFXDTC aqueous solution with a concentration of 1g to 2g / L to the above solution, mix well, and continue the reaction in a water bath at 100°C for 20 to 30 minutes to obtain the present invention. said 99 Tc m O-CPFXDTC complex.

[0023] right 99 Tc m Performance determination of O-CPFXDTC complex:

[0024] 1. 99 Tc m Thin Layer Chromatography (TLC) Identification of O-CPFXDTC

[0025] Identification by thin layer chromatography (TLC) 99 Tc m O-CPFXDTC, the system used is polyamide-physiological saline. in this system 99 Tc m -GH, 99 Tc ...

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Abstract

The invention discloses a TcO nucleus marked ciprofloxacin dithiocarbamate complex and a preparation method and applications thereof. The complex uses the TcO nucleus as a central nucleus; and four sulphur atoms in two CPFXDTC ligand molecules generate complexation reaction with Tc to obtain a TcO-CPFXDTC complex. The complex has the advantages of high radiochemical purity, good stability, high intussusception of inflammation, rational target-to-nontarget ratio of inflammation to muscle, and low intussusception of liver, lung, spleen and the like. Therefore, the complex is a new developer of inflammation, with popularization and application values.

Description

Technical field [0001] The present invention relates to 99 Tc m O the field of radiopharmaceutical chemistry and clinical nuclear medicine technology for nuclear labeling, specifically relating to a 99 Tc m O nucleus-labeled ciprofloxacin dicarbaminate complex, its preparation method and application. Background technique [0002] Nuclide inflammation imaging is an important method for early detection of lesions. Inflammation imaging agents are divided into proteins, antibiotics, leukocytes, and small molecule compounds according to different markers. The nuclides used are as follows: 67 Ga, 111 In and 99 Tc m . because 99 Tc m Excellent nuclear properties, cheap and easy to obtain and other advantages make it one of the preferred nuclides for radiopharmaceutical research. 99 Tc m Labeled white blood cell imaging is known as the "gold standard" for detecting acute and chronic inflammatory lesions, but the labeling process is complicated and cross-infection is prone...

Claims

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Application Information

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IPC IPC(8): A61K51/04A61K103/10
Inventor 张俊波张仕坚王跃王学斌唐志刚张现忠陆洁
Owner BEIJING NORMAL UNIVERSITY
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