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Pericardial collagen composite material and preparation method and application thereof

A composite material and collagen technology, applied in prosthetics, tissue regeneration, medical science, etc., can solve the problems of osteoinductivity and bionic bone structure, and achieve sufficient space maintenance ability, good compactness, and biodegradation time prolonged effect

Active Publication Date: 2017-06-27
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artificial bone materials have been formed rapidly in recent years, and can better synthesize bone repair substitute materials that are close to the shape of defective bone, but their osteoinductive and biomimetic bone structures are not ideal enough

Method used

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  • Pericardial collagen composite material and preparation method and application thereof
  • Pericardial collagen composite material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment provides a polysaccharide-containing pericardial composite material, which is prepared by the following steps:

[0028] 1. Remove the fat from the pericardium purchased in the market with a glass plate or steel plate, and freeze it in the refrigerator for 24 hours;

[0029] 2. Put the fat-removed pericardium into a beaker and rinse it with deionized water for 3 times, each time for 5 minutes. At this time, if there is any fat tissue, remove it sharply with scissors and tweezers;

[0030] 3. Degreasing: the ratio of solid to liquid is 3:1, the temperature is 40°C, add a degreasing agent with a weight ratio of 0.6% of pig pericardium, and act for 1.5 hours. The ratio of solid to liquid is 4:1, washed twice with water;

[0031] 4. Alkali treatment: the ratio of solid to liquid is 3:1, the temperature is 28°C, add sodium hydroxide with a mass ratio of 0.8% of pig pericardium, and 0.6% degreasing agent, turn for 30 minutes, turn for 10 minutes every 50 minut...

Embodiment 2

[0043] This embodiment provides a pericardial composite material containing bone substitute material or growth factor, which is prepared by the following steps:

[0044] Operate according to example 1

[0045] 7. Compounding: liquid ratio 2.5:1, temperature 35°C, pH value 6.4-6.8, hydroxyapatite 2.0%, react for 90 minutes, wash with PBS;

[0046] 8. Cross-linking: liquid ratio 2.0:1, temperature 30°C, glutaraldehyde 0.2%, add in portions, adjust the pH value to 8, react for 60 minutes, wash with water until the pH value is neutral;

[0047] 9. Washing with PBS: liquid ratio 3:1, temperature 25°C, wash 3 times.

[0048] 10. Disinfection: cobalt 60 irradiation sterilization.

[0049] The pericardial collagen composite material prepared by the above method can be used as a bone repair material.

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Abstract

The invention relates to a pericardial collagen composite material and a preparation method and application thereof. The pericardial collagen composite material contains at least one of chitosan, hyaluronic acid, chondroitin sulfate and other water-soluble polysaccharide or hydroxyapatites, BMP, PDGF and other bone replacement materials and bone growth factors. The preparation method of the pericardial collagen composite material comprises the steps that a pigpericardium is taken to remove chunk fat, and then water immersion, degreasing, alkali soaking, dealkalization, enzymolysis, compounding, crosslinking and disinfection. The pericardial collagen composite material can be used as a tooth implantation guided bone regeneration barrier isolating membrane, an oral cavity restorationmembrane and a bone repair material. The pericardial collagen composite materialhas good biocompatibility and compactness, high mechanical strength and excellent controllable degradation time.

Description

technical field [0001] The invention relates to the fields of chemical engineering, bioengineering, medicine and material science, and in particular to a pericardial collagen composite material and its preparation method and application. Background technique [0002] Guided bone regeneration membranes are divided into two categories: non-absorbable membranes and absorbable membranes. Non-absorbable membranes include polytetrafluoroethylene (expanded polytetrafluoroethylene, e-PTFE) and titanium-enhanced polytetrafluoroethylene (Ti-e-PTFE) membranes. , peptide film, these polymer materials have good physical, chemical, thermal and mechanical properties, but due to their inertness, they cannot be degraded in the body, and patients need to undergo a second operation to remove them, which will cause additional surgical costs and pain, and prolong the life of the patient. the patient's healing cycle. Absorbable membranes overcome this shortcoming and are widely used. However, cu...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/20A61L27/12A61L27/50
CPCA61L27/12A61L27/20A61L27/3604A61L27/3687A61L27/50A61L2430/02A61L2430/12A61L2430/40C08L5/08
Inventor 曹成波闫建伟王倩沈新春张春莲
Owner SHANDONG UNIV
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