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Preparation method of amino acid chelated calcium and calcium supplement preparation comprising the chelated calcium

An amino acid, chelated calcium technology, applied in the field of calcium supplements, can solve the problems of inability to realize large-scale industrial production, incomplete reaction, low chelation rate, etc., and achieves improved chelation rate and reaction efficiency, short reaction time, The effect of high absorption rate

Active Publication Date: 2018-05-22
岳智广
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, amino acid chelated calcium is produced by pure chemical methods, that is, amino acids and calcium hydroxide are mixed in a certain proportion in a closed container for reaction. However, the above-mentioned method has the following disadvantages: (1) The preparation time is long and the yield is low. (2) The chelation rate is low and the reaction is incomplete; (3) The solubility in water is low, which affects the absorption

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  • Preparation method of amino acid chelated calcium and calcium supplement preparation comprising the chelated calcium

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Embodiment 1

[0033] This embodiment provides a method for preparing amino acid chelated calcium, which includes the following steps:

[0034] (1) Weigh the calcium-containing compound and the amino acid ligand in a molar ratio of 1:1 and mix them thoroughly to obtain a mixture; wherein the calcium-containing compound is Ca(OH) 2 , CaO, CaCl 2 A mixture composed of a molar ratio of 2:2:1, and the amino acid ligand is a mixture composed of L-aspartic acid, D-methionine, and glycine in a molar ratio of 4:2:1;

[0035] (2) Add 4.5 times the mass of water to the mixture of step (1), mix well and perform the first filtration to obtain a first suspension with a solid particle size of less than 20 μm in the filtrate;

[0036] (3) Adjust the pH of the first suspension to 7, and then conduct homogenization for 2 hours. After the homogenization is completed, nanogrind with a high-pressure liquid nanomill, and then perform a second filtration to obtain a solid filtrate The second suspension with a particle s...

Embodiment 2

[0045] This embodiment provides a method for preparing amino acid chelated calcium, which includes the following steps:

[0046] (1) Weigh the calcium-containing compound and the amino acid ligand at a molar ratio of 4:1 and mix them thoroughly to obtain a mixture; wherein the calcium-containing compound is Ca(OH) 2 , CaO, CaCl 2 A mixture composed according to a molar ratio of 4:1:2, and the amino acid ligand is a mixture composed of L-aspartic acid, L-methionine and glycine according to a molar ratio of 6:1:2;

[0047] (2) Add 5.5 times the mass of water to the mixture of step (1), mix well and perform the first filtration to obtain the filtrate as a first suspension with a solid particle size of less than 20 μm;

[0048] (3) Adjust the pH of the first suspension to 7.5 first, and then conduct a homogenization treatment for 6 hours. After the homogenization treatment is completed, use a high-pressure liquid nanomill for nanogrinding, and then perform a second filtration to obtain a ...

Embodiment 3

[0057] This embodiment provides a method for preparing amino acid chelated calcium, which includes the following steps:

[0058] (1) Weigh the calcium-containing compound and the amino acid ligand in a molar ratio of 2:1 and mix them thoroughly to obtain a mixture; wherein the calcium-containing compound is Ca(OH) 2 , CaO, CaCl 2 A mixture composed according to a molar ratio of 3:1.5:1.5, and the amino acid ligand is a mixture composed of L-aspartic acid, D-methionine, L-methionine, and glycine according to a molar ratio of 5:0.5:0.5:1.5;

[0059] (2) Add 5 times the mass of water to the mixture of step (1), mix well and perform the first filtration to obtain a first suspension with a solid particle size of less than 20 μm in the filtrate;

[0060] (3) Adjust the pH of the first suspension to 7.3 first, and then conduct a homogenization treatment for 4 hours. After the homogenization treatment is completed, use a high-pressure liquid nanomill for nanogrinding, and then perform a secon...

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Abstract

The invention relates to a preparation method of amino acid chelated calcium. The preparation method comprises the following steps: preparing a mixture by mixing a calcium-containing compound and an amino acid ligand according to a specific ratio, adding a right amount of water into the mixture, performing primary filtration on the material to obtain a first suspension having a solid particle size less than 20 mu m, regulating the pH value, performing homogenization treatment to enable the solid particle size to reach the nano level, performing secondary filtration after the homogenization treatment filtration a second suspension having a solid particle size less than 100 nm, and finally performing chelation reaction on the second suspension at specific temperature and pressure. Thus, the chelation rate and the reaction efficiency of the chelation reaction are greatly improved, the reaction time is short, and the reaction is complete. The amino acid chelated calcium is high in yield; the mass percent of the calcium element in the amino acid chelated calcium is up to 12.9%; and the amino acid chelated calcium prepared by the method can be absorbed by a human body very easily, and the absorptivity is up to 95% or above.

Description

Technical field [0001] The invention belongs to the technical field of calcium supplements, and specifically relates to a preparation method of amino acid chelated calcium and a calcium supplement preparation comprising the chelated calcium. Background technique [0002] Calcium is one of the most important elements of the human body. The function of almost every system of the human body is related to calcium. The harm of calcium deficiency to the human body has become a remarkable worldwide problem. Especially the impact on infants, the elderly, pregnant women and patients with certain diseases is more serious. Scientific calcium supplementation, beneficial to health, has become a consensus of people. Normal people’s daily physiological requirement for calcium is 300-500 mg, while according to Chinese eating habits, the daily calcium intake from food is only 150-200 mg. [0003] According to incomplete statistics, there are currently more than 200 calcium supplements on the dome...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/16C07C229/76
CPCA23V2002/00A23V2200/30A23V2250/0622A23V2250/0632A23V2250/0616A23V2250/636A23V2250/264A23V2250/708
Inventor 岳智广
Owner 岳智广
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