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Preparation and application of phenylalanine dipeptide-graphene quantum dot composite material

A technology of graphene quantum dots and phenylalanine dipeptide, which is applied in the fields of molecular recognition and electrochemical research, and achieves the effects of good recognition ability, simple and environmentally friendly preparation method

Active Publication Date: 2017-06-13
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still no reports on the use of graphene quantum dot electrochemical modification materials as electrochemical modification materials.

Method used

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  • Preparation and application of phenylalanine dipeptide-graphene quantum dot composite material
  • Preparation and application of phenylalanine dipeptide-graphene quantum dot composite material
  • Preparation and application of phenylalanine dipeptide-graphene quantum dot composite material

Examples

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Effect test

Embodiment 1

[0030] The preparation of phenylalanine dipeptide-graphene quantum dot composite material comprises the following steps:

[0031] (1) Weigh the solid citric acid and grind it into a white powder, add it into a crucible, and heat it with a program-controlled box-type electric furnace. After the reaction is over, take out the solid sample, add an appropriate amount of ultrapure water, and dissolve it ultrasonically. After the product was fully dissolved, the yellow transparent solution was obtained by suction filtration, and prepared into a 2 mg / mL graphene quantum dot solution, which was stored in the dark at room temperature.

[0032] (2) Take 1.00 mg of phenylalanine dipeptide powder in 20 μL of hexafluoroisopropanol to prepare a 50 mg / mL hexafluoroisopropanol solution of phenylalanine dipeptide, add ultrapure water to the above solution, Dilute to 3mg / mL phenylalanine dipeptide solution. Then, 20 μL of the graphene quantum dot solution prepared in step (1) was added to the...

Embodiment 2

[0036] The phenylalanine dipeptide-graphene quantum dot composite modified electrode prepared in Example 1 was placed in a 5mM potassium ferricyanide solution, and was used under the electrochemical window of -0.2~0.6V (vs.SCE). The modified electrode was characterized by cyclic voltammetry, with a scan rate of 0.1V / s and a scan cycle of 20. The results are shown in the attached figure 2 As shown, the phenylalanine dipeptide-graphene quantum dot composite modified electrode shows a reversible symmetric cyclic voltammogram.

Embodiment 3

[0038] The phenylalanine dipeptide-graphene quantum dot composite modified electrode prepared in Example 1 was placed in 25mL of 0.5mM tryptophan enantiomer solution, and after standing for 60s, it was heated at 0.4~1.2V (vs. The differential pulse voltammogram was recorded within the electrochemical window of SCE). After each measurement, the modified electrode was swept in 25mL 0.1M sodium dihydrogen phosphate (pH=7) to restore the electrode activity. The recognition effect of tryptophan enantiomer by the phenylalanine dipeptide-graphene quantum dot composite modified electrode is shown in the appendix image 3 , the phenylalanine dipeptide-graphene quantum dot composite modified electrode has a good recognition effect on the tryptophan enantiomer (R L / D is 2.71).

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Abstract

The invention relates to preparation and application of a phenylalanine dipeptide-graphene quantum dot composite material. The preparation includes the following steps: preparation of graphene quantum dots, preparation of the phenylalanine dipeptide-graphene quantum dot composite material, preparation of a phenylalanine dipeptide-graphene quantum dot composite material modified electrode, and electrochemical method identification of tryptophan enantiomers. The beneficial effects are that the preparation method of the phenylalanine dipeptide-graphene quantum dot composite material modified electrode is simple and environment-friendly, and the phenylalanine dipeptide-graphene quantum dot composite material modified electrode has better tryptophan enantiomer recognition ability because of some optical rotation of the phenylalanine dipeptide.

Description

technical field [0001] The invention relates to the preparation and application of a phenylalanine dipeptide-graphene quantum dot composite material, which belongs to the field of molecular recognition and electrochemical research. [0002] technical background [0003] Proteins, nucleic acids, polysaccharides, and amino acids are essential substances for life activities, and almost all of them have chirality. For chiral compounds, when its two enantiomers are in an achiral environment, except for optical activity, their chemical and physical properties are completely identical, and their nuclear magnetic resonance and infrared spectra are also completely consistent. However, when there is an external environment, the two optical isomers exhibit completely different properties. Therefore, chiral recognition has important research significance. Currently, chiral recognition research methods mainly include capillary electrophoresis, chromatography, fluorescence detection and ...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 孔泳郭莉丽鲍丽平
Owner CHANGZHOU UNIV
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