Strontium-containing xenogeneic bone scaffold and preparation method thereof
A bone scaffold and xenogeneic technology, applied in the field of materials, can solve the problems of long preparation period and limited strontium content, and achieve the effects of prolonging the release period, easy operation and short period
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Embodiment 1
[0041] a) Select porcine femoral cancellous bone, cut into pieces, stir in 80°C water, and change the liquid every 3 hours. When the aqueous solution was bloodless, the bones were transferred to 75% (v / v) ethanol and stirred for 4 hours. The bones were then stirred in 10% (w / v) sodium hydroxide for 2 h. Finally the bones were stirred in 30% (v / v) hydrogen peroxide for 12h. The bone was washed with water, calcined at 800°C for 5 hours, and the heterogeneous bone scaffold was obtained after cooling.
[0042] b) Preparation of SrCl 2 Aqueous solution (2M), soak the scaffold in it, stir for 6 hours, absorb excess liquid, bake at 60°C for 2 hours, and obtain the heterogeneous bone / Sr scaffold.
[0043] c) Prepare an organic solution of polycaprolactone (PCL) in dichloromethane (DCM) (10%, w / v), and coat the organic solution on the heterogeneous bone / Sr scaffold. After the DCM was volatilized, it was heated at 60°C for 2 hours, and after cooling, the heterogeneous bone / Sr / PCL sc...
Embodiment 2
[0050] Select porcine femoral cancellous bone, cut into pieces, stir in 80°C water, and change the liquid every 3 hours. When the aqueous solution was bloodless, the bones were transferred to 75% (v / v) ethanol and stirred for 4 hours. The bones were then stirred in 10% (w / v) sodium hydroxide for 2 h. Finally the bones were stirred in 30% (v / v) hydrogen peroxide for 12h. The bone was washed with water, calcined at 800°C for 5 hours, and the heterogeneous bone scaffold was obtained after cooling. Prepare SrCl 2 Aqueous solution (2M), soak the scaffold in it, stir for 6 hours, absorb excess liquid, bake at 60°C for 2 hours, and obtain the heterogeneous bone / Sr scaffold. An organic solution of polycaprolactone (PCL) in dichloromethane (DCM) (15%, w / v) was prepared, and the organic solution was coated on the xenograft bone / Sr scaffold. After the DCM was volatilized, it was heated at 60°C for 3 hours, and after cooling, the heterogeneous bone / Sr / PCL scaffold was obtained and sto...
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