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Tilmicosin controlled-release microcapsule preparation containing plant essential oil and preparation method thereof

The technology of tilmicosin and plant essential oil is applied in the field of tilmicosin sustained-release microcapsule preparation containing plant essential oil and its preparation field, and can solve the problems of irritating gastric mucosa, difficult to achieve taste masking, complicated clinical operation and the like , to increase appetite, reduce feed-to-meat ratio, and eliminate cross-contamination

Inactive Publication Date: 2017-05-31
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, injections are administered by individuals, and the clinical operation is cumbersome, and the safety is low. Once overdose, it is easy to cause side effects and even death in animals; soluble powders and solutions are administered orally, which is difficult to achieve the purpose of taste masking and has poor palatability.
Mixed feeding is a relatively simple and easy way of administration, but ordinary powders and premixes have poor taste-masking effect, poor palatability, no sustained-release function, unstable in the stomach, and irritating to the gastric mucosa; and poor fluidity , low dispersion, difficult to mix when mixing

Method used

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  • Tilmicosin controlled-release microcapsule preparation containing plant essential oil and preparation method thereof
  • Tilmicosin controlled-release microcapsule preparation containing plant essential oil and preparation method thereof
  • Tilmicosin controlled-release microcapsule preparation containing plant essential oil and preparation method thereof

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preparation example Construction

[0031] This embodiment also provides a preparation method of tilmicosin sustained-release microcapsules containing plant essential oils, which is used to prepare the above-mentioned tilmicosin sustained-release microcapsules containing plant essential oils, which includes the following Preparation steps:

[0032] 1) Weigh the auxiliary materials according to the mass percentage of the formula, and heat and melt the auxiliary materials within the temperature range of 60°C-120°C;

[0033] 2), accurately weigh the raw materials according to the mass percentage of the formula, and add the weighed raw materials into the molten liquid prepared in step 1), stir evenly and cool;

[0034] 3) The mixed liquid prepared in step 2) is sprayed, condensed, granulated and sieved, and collected to obtain a granular tilmicosin sustained-release microcapsule preparation containing plant essential oils.

[0035] In the step 1), different temperatures can be selected for heating according to diff...

Embodiment approach 1

[0039] 1), accurately weigh auxiliary materials: 80% fat powder and 5% paraffin, heat and melt at 90°C;

[0040] 2), accurately weigh the raw materials: 10% tilmicosin and 5% oregano oil, add successively to the molten liquid prepared in step 1), stir evenly, and cool;

[0041] 3), the mixed solution prepared in step 2) is sprayed and condensed to granulate, sieved, and collected to obtain a tilmicosin sustained-release microcapsule preparation containing plant essential oils.

Embodiment approach 2

[0043] 1), accurately weigh auxiliary materials: 70% stearic acid and 5% beeswax, heat and melt at 80°C;

[0044] 2), accurately weigh the raw materials: 20% tilmicosin and 5% cinnamon oil, sequentially added to the molten liquid prepared in step 1), stirred evenly, and cooled;

[0045] 3), the mixed solution prepared in step 2) is sprayed and condensed to granulate, sieved, and collected to obtain a tilmicosin sustained-release microcapsule preparation containing plant essential oils.

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Abstract

The invention relates to the technical field of veterinary medicines, and discloses a tilmicosin controlled-release microcapsule preparation containing plant essential oil and a preparation method thereof. The tilmicosin controlled-release microcapsule preparation containing the plant essential oil is prepared from raw materials with the mass percentage of 10% to 50% and the balance of an auxiliary material by adopting mist spraying condensation granulation, wherein the raw materials comprise tilmicosin and the plant essential oil; and the auxiliary material is the mixture of one or more of fatty powder, hydrogenated vegetable oil, stearic acid, stearyl alcohol, glycerin monostearate, monoglyceride and wax. The tilmicosin and the plant essential oil are simultaneously contained in the tilmicosin controlled-release microcapsule preparation containing the plant essential oil, the animal diseases are prevented and controlled, the using amount of antibiotics is reduced, and the pollution caused by the antibiotics is reduced; the bitter taste of the tilmicosin is covered up, the ingestion of animals is induced, and the preparation can be dissolved until reaching intestinal tracts, so that the holding time of effective blood concentration of medicine is prolonged, and the cross contamination caused in the feed mixing process is eliminated.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a tilmicosin sustained-release microcapsule preparation containing plant essential oil and a preparation method thereof. Background technique [0002] Tilmicosin (Tilmicosin) is a semi-synthetic macrolide animal-specific antibacterial drug developed in the 1980s. It has the advantages of broad antibacterial spectrum, strong antibacterial effect, and low drug resistance. Tilmicosin is effective against all Gram-positive bacteria, some Gram-negative bacteria, spirochetes, mycoplasma, etc., especially against Actinobacillus pleuropneumoniae, Pasteurella hemolytica, Pasteurella multocida and Mycoplasma of livestock and poultry It has stronger antibacterial activity than tylosin. Therefore, tilmicosin is widely used in livestock and poultry farming. [0003] Tilmicosin tastes extremely bitter, has poor palatability, animals do not like to eat it, and is irrit...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/50A61K47/44A61K45/06A61K31/706A61P31/04A61K36/53A61K36/54A61K31/255
CPCA61K45/06A61K9/0002A61K9/5063A61K31/255A61K31/706A61K36/53A61K36/54A61K2300/00
Inventor 杨小云刘肖娟谭志坚黄显会王俊廖贵城符德文
Owner FOSHAN STANDARD BIO TECH
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