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Film coating premix for soft capsules and preparation method of film coating premix

A film coating and premix technology, which is used in capsule delivery, medical preparations with inactive ingredients, pharmaceutical formulations, etc., can solve the problems of damaged capsule skin, oil leakage, deformation, adhesion, etc., and achieves the effect of improving preservation. Technological progress is obvious, the effect of solving oral odor

Inactive Publication Date: 2017-05-31
SHANGHAI NEW PHIL BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of film coating premix and preparation method for soft capsule, described this film coating premix and preparation method for soft capsule are to solve existing soft capsule Difficult to preserve, easy to agglomerate, adhesion, deformation, capsule skin damage, oil leakage, seam cracking technical problems

Method used

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  • Film coating premix for soft capsules and preparation method of film coating premix
  • Film coating premix for soft capsules and preparation method of film coating premix
  • Film coating premix for soft capsules and preparation method of film coating premix

Examples

Experimental program
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Effect test

Embodiment 1

[0027] This example is a health care product garlic essence soft capsule, which is filled with garlic essential oil, which emits some garlic smell.

[0028] Recipe one: IR 33%, hypromellose 30%, polyethylene glycol 7%, methacrylic acid-ethyl acrylate polymer 10%, talc 19.5%, soybean lecithin 0.5%.

[0029] Depend on figure 1 It can be seen that the soft capsules that have been coated but not coated are all agglomerated during storage, and there is no agglomeration after two years of storage with coating, which solves the defects of soft capsules during storage and the odor in the mouth .

Embodiment 2

[0031] This example is an Omega 3 soft capsule product, which is filled with perilla oil and vitamins.

[0032] Recipe 2: IR 37%, hypromellose 24%, polyethylene glycol 16%, talc 22%, soybean lecithin 1%.

[0033] Depend on figure 2 It can be seen that uncoated products will produce clumping, adhesion, and seam cracking during consumption and use, giving people a sense of quality problems. These defects in the process of consumer use can be solved by coating.

Embodiment 3

[0035] In this example, the coating can be made into various colors to improve the appearance and grade of the product and solve the defects of preservation.

[0036] Recipe three: IR 38%, hypromellose 20%, polyethylene glycol 16%, colorant 1%, talcum powder 23.5%, soybean lecithin 1.5%.

[0037] Depend on image 3 It can be seen that making soft capsules into various colors facilitates consumers to distinguish the types of drugs and facilitates storage

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Abstract

The invention provides a film coating premix for soft capsules. The film coating premix consists of a film-forming agent, a colorant, and an antisticking agent, and in the film coating premix for the soft capsules, the mass percentage of the film-forming agent is 72-80%, the mass percentage of the colorant is 0-3%, and the mass percentage of the antisticking agent is 17-25%. The invention also provides a preparation method of the film coating premix, and the preparation method comprises the following steps: mixing, grinding and crushing colorant materials to obtain a mixture with a uniform color; adding film-forming agent materials into a mixing machine, then adding the mixture of the colorant into the mixing machine, performing mixing, grinding, crushing and re-mixing to ensure that the mixture is fully ground and mixed, and performing screening after homogenization, thereby obtaining the film coating premix for the soft capsules. The premix provided by the present invention can effectively solve the technical problems of capsule joint cracking, adhesion and agglomeration of current soft capsules in use and preservation.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and relates to a pharmaceutical excipient, in particular to a coating material, in particular to a film coating premix for soft capsules and a preparation method thereof. Background technique [0002] Soft capsule preparations are commonly used in medicines or health foods. At present, the market for health care products is growing, and the demand for soft capsules is also increasing. Played a big role. [0003] Soft capsules are made of gelatin, glycerin or other suitable pharmaceutical excipients alone or in combination. Soft capsule preparations are mostly used for water-insoluble; liquid oily substances can be directly sealed into capsules, which is a new type of preparation. Soft capsule preparations have many advantages and can solve some problems that cannot be solved by traditional Chinese medicine preparations, but there are also some problems at the same time. Soft capsules are not ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/32
CPCA61K9/4891A61K47/32
Inventor 吴兴安左成林
Owner SHANGHAI NEW PHIL BIOLOGICAL TECH CO LTD
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