Solid preparation fabrication equipment and method

Abstract

The invention provides solid preparation fabrication equipment and method. The solid preparation fabrication equipment is characterized by comprising a spray freeze-drying device and a solid preparation forming device. The solid preparation fabrication method includes the steps that a solution, mixed suspension liquid or emulsion containing medicine effective ingredients is prepared, spray freezing and drying are performed through the spray freeze-drying device under the stirring or non-stirring state, particles obtained through spray freezing and drying are directly fabricated into a solid preparation through the solid preparation forming device, or the particles obtained through spray freezing and drying are mixed with at least one accessory and then fabricated into the solid preparation through the solid preparation forming device. The solid preparation fabrication equipment and method are particularly suitable for but not limited to the production or research process of materials of properties of sensitization, low content proportion, biological activity, heat sensitivity and the like.

Description

technical field [0001] The invention relates to a solid preparation manufacturing equipment and method. Background technique [0002] In general, the production / development process of tablets or capsules generally has pretreatment processes such as granulation, granulation, drying, and mixing. This process has its inherent disadvantages, such as time-consuming, uneven mixing, heat sensitivity The impact of the substance is relatively large, and it is easy to fly dust. For the pre-treatment of allergenic substances, factors such as airtightness and cleanability of each link also need to be considered, which will increase additional cost input. [0003] There are many granulation methods commonly used at present, including high-shear wet granulation, fluidized bed granulation, dry granulation, spray drying granulation, etc., but all methods (except dry granulation) require heated It has a greater impact on heat-sensitive substances, and spray drying is prone to sticking to t...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to develop a solid preparation with high production efficiency and suitable for heat-sensitive substances in view of the defects of the current tablet and capsule pretreatment process that are cumbersome, have an impact on heat-sensitive substances, and consume time and energy in conventional freeze-drying. equipment and methods

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