A kind of pharmaceutical composition against fungal infection and its preparation method, preparation and application

An antifungal and composition technology, which is applied in the field of antifungal infection pharmaceutical compositions, can solve the problems of not being able to better meet the needs of patients, slow onset of therapeutic effects, and poor durability of curative effects

Active Publication Date: 2020-08-07
CHUXIONG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The classic drug currently on the market for the treatment of fungal infections is griseofulvin, and the drugs for local application are mainly salicylic acid, benzoic acid and other preparations. Since the 1970s, azole antifungal drugs have been mainly used for treatment. The main drugs are clotrimazole, miconazole, econazole and bifonazole, etc., but these antifungal drugs are antifungal drugs, and there is a possibility of relapse after discontinuation. Antibacterial and bactericidal drugs are mainly allylamines, such as naftifine, butenafine, etc., but with the large-scale clinical use, these drugs inevitably have some drug resistance problems. In terms of traditional Chinese medicine treatment, Now clinically, external treatment is mainly used for treatment. Specifically, there are many dosage forms such as tincture, lotion, vinegar, liniment and ointment, and most of them have certain effects, but these medicines are mainly confirmed by preliminary clinical trials. However, strict antibacterial tests in vitro have not been conducted to confirm its exact efficacy, and the onset of therapeutic effect is slow, and the durability of curative effect is poor, so it cannot better meet the needs of patients.

Method used

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  • A kind of pharmaceutical composition against fungal infection and its preparation method, preparation and application

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preparation example Construction

[0018] The preparation method of the antifungal infection pharmaceutical composition of the present invention comprises the steps of pretreatment, extraction and posttreatment, specifically comprising:

[0019] A. Pretreatment: Weigh each raw material according to the formula ratio, pulverize, sieve and mix to obtain material a;

[0020] B. Extraction: Adding 3 to 8 times the weight of material a to material a with an ethanol solution with a volume percentage concentration of 60 to 90% to obtain extract b;

[0021] C. Post-processing: the extract b is dried, pulverized and sieved to obtain the target pharmaceutical composition against fungal infection.

[0022] The crushing and sieving described in step A is crushing through a 10-80 mesh sieve.

[0023] The extraction described in the B step is leaching or percolation extraction.

[0024] Described extraction method is:

[0025] Method 1: Take the material a that has passed through a 80-mesh sieve, add an ethanol solution w...

Embodiment 1

[0040] Take 20 parts of Hydrangea Fangfeng, 20 parts of Jiuliguang, 20 parts of Sophora flavescens, 20 parts of Cortex Phellodendri and 10 parts of Flying Grass

[0041] Weigh each raw material according to the formula ratio, pulverize and cross an 80-mesh sieve and mix to obtain material a; get the material a through an 80-mesh sieve, add an ethanol solution that is 8 times the weight of material a and have a concentration of 60% by volume, and store in dark at room temperature place for 7 days, filter to obtain the extract b, dry the extract b, pulverize and sieve the target product which is the pharmaceutical composition for anti-fungal infection.

Embodiment 2

[0043] Take 25 parts of Hydrangea Fangfeng, 25 parts of Jiuliguang, 25 parts of Sophora flavescens, 25 parts of Cortex Phellodendri and 15 parts of Flying Grass

[0044]Weigh each raw material according to the formula ratio, pulverize and cross an 80-mesh sieve and mix to obtain material a; get the material a through an 80-mesh sieve, add an ethanol solution that is 8 times the weight of material a and have a concentration of 60% by volume, and store in dark at room temperature place for 7 days, filter to obtain the extract b, dry the extract b, pulverize and sieve the target product which is the pharmaceutical composition for anti-fungal infection.

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Abstract

The invention discloses an anti-fungal-infection pharmaceutical composition and a preparation method thereof, and preparations and application of the pharmaceutical composition. The anti-fungal-infection pharmaceutical composition is prepared from the following raw materials in parts by weight: 20-30 parts of Leucas, 20-30 parts of Senecio scandens, 20-30 parts of kuh-seng, 20-30 parts of phellodendron bark and 10-20 parts of hairy euphorbia. The preparation method comprises the following steps: pretreatment, extraction and after-treatment. The preparations are tablets, capsules, granules, pills and tinctures prepared by adding pharmaceutically acceptable auxiliary materials into the anti-fungal-infection pharmaceutical composition. The application is the application of the anti-fungal-infection pharmaceutical composition in preparation of drugs for preventing / treating fungal infection diseases. The anti-fungal-infection pharmaceutical composition has the function of treating tinea manus and pedis and onychomycosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for antifungal infection and its preparation method, preparation and application. Background technique [0002] Fungi are a type of eukaryote. The most common fungi are various types of mushrooms, but fungi also include molds and yeasts. More than 70,000 species of fungi have now been discovered, estimated to be only a small half of all that exist. Most fungi were originally classified as animals or plants. [0003] At present, fungi have become independent kingdoms in taxonomy, paralleling the kingdoms of animals, plants, prokaryotes and protists. Fungi have solid cell walls and true nuclei, do not contain chlorophyll, are heterotrophic, live in a parasitic or saprophytic manner, and typically reproduce both sexually and asexually, producing spores of various forms. According to the growth characteristics and morphological difference...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P31/10A61P17/00
CPCA61K36/28A61K36/282A61K36/47A61K36/489A61K36/53A61K36/756A61K2236/333A61K2300/00
Inventor 潘立文杨先振
Owner CHUXIONG MEDICAL COLLEGE
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