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A kind of compound glycyrrhizin tablet and preparation method thereof

A technology of glycyrrhizin tablets and glycyrrhizin, which is applied in the field of compound glycyrrhizin tablets and its preparation, can solve the problems affecting the stability and dissolution rate of tablets, inconvenient use of injections, and complicated prescription processes. Achieve the effects of good dissolution rate and stability, low production cost and simple process

Active Publication Date: 2019-07-09
LEPU PHARMACEUTICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the compound glycyrrhizin preparations available for patients on the market are injections and tablets. In the case of long-term medication, the injections are very inconvenient to use and the patient’s compliance is poor; while the tablets are sugar-coated tablets, the prescription process is more complicated, and When the strength of the tablet is guaranteed, it often affects the stability and dissolution rate of the tablet drug

Method used

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  • A kind of compound glycyrrhizin tablet and preparation method thereof
  • A kind of compound glycyrrhizin tablet and preparation method thereof
  • A kind of compound glycyrrhizin tablet and preparation method thereof

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Embodiment 1-4

[0020] A compound glycyrrhizin tablet is a tablet made of monoammonium glycyrrhizinate, glycine and DL-methionine as main ingredients, and fillers and disintegrating agents as auxiliary materials; each compound glycyrrhizin tablet The consumption of each raw material in the agent is as shown in table 1:

[0021] The consumption of each raw material in each tablet of the embodiment of table 1

[0022]

[0023] The preparation method of compound glycyrrhizin tablet described in embodiment 1 and embodiment 3 comprises the following steps:

[0024] (1) Grind and sieve each raw material respectively, pass the main drug raw material and filler through a 80-mesh sieve, and pass the xanthan gum through a 200-mesh sieve;

[0025] (2) Weigh each raw material according to the mass ratio, first mix the main drug raw materials and filler evenly, then add xanthan gum, and mix for 45 minutes;

[0026] (3) Press the product obtained in step (2) into tablets to obtain the product.

[002...

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Abstract

The invention discloses compound glycyrrhizin tablets. The compound glycyrrhizin tablets are prepared from a main drug raw material comprising glycyrrhizic acid ammonium salt, glycine and DL-methionine and an auxiliary material comprising a filling agent and a disintegrating agent. The mass ratio of the main drug raw material to the auxiliary material is 1:(1.7-2.8). The filling agent is prepared by evenly mixing mannitol and starch in a mass ratio of 2:1, and the disintegrating agent is xanthan gum. The invention further discloses a preparation method of the compound glycyrrhizin tablets. The method sequentially comprises the steps of grinding, screening, mixing and tabletting, and then the compound glycyrrhizin tablets are prepared. Due to mannitol in the auxiliary material, the situation that the drug quality is unqualified caused by moisture absorption of glycyrrhizic glycoside can be avoided, and the sweetness of mannitol can mask the bitterness of the tablets; by matching with the starch and xanthan gum in a certain ratio, the raw materials of the tablets are good in fluidity and pressing-ability; the technology is simple, energy conservation and environment protection are achieved, and the production cost is low.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound glycyrrhizin tablet and a preparation method thereof. Background technique [0002] The compound glycyrrhizin preparation (trade name: Meineng) was developed by Mino Fayuan Pharmaceutical Co., Ltd. in Japan. It was first produced and marketed in Japan in 1948. It was originally used for the treatment of skin diseases. It has two dosage forms: injection and solid preparation. In 1958, it tried to treat liver disease with Meinol, and it was officially reported in the late 1970s that it was used clinically as a preparation for the treatment of chronic hepatitis. Japan has verified its definite curative effect in the treatment of chronic hepatitis from liver histopathology. Retrospective studies on the treatment of hepatitis C have shown that the incidence of liver cirrhosis can be greatly reduced; 22 years of long-term efficacy observations...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/36A61K31/704A61K31/198A61P1/16
CPCA61K9/0095A61K9/2018A61K9/205A61K9/2059A61K31/198A61K31/704A61K2300/00
Inventor 李春丽王庆鹏孙冬梅骆献丽贾银芳
Owner LEPU PHARMACEUTICAL CO LTD
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