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Sanguisorba officinalis sapogenin oral emulsion as well as preparation method and applications thereof

A technology of Ulmus saponin oral emulsion and Sangui saponin, which is applied in the field of Sangui saponin oral emulsion and its preparation, to achieve the effects of treatment and/or prevention, and improvement of drug solubility and dissolution

Inactive Publication Date: 2017-05-03
SICHUAN YINGLU WEITE PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no public report on the preparation of oral emulsion with saponin from Burnet eucalyptus as the active ingredient for the treatment and / or prevention of myelosuppression

Method used

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  • Sanguisorba officinalis sapogenin oral emulsion as well as preparation method and applications thereof
  • Sanguisorba officinalis sapogenin oral emulsion as well as preparation method and applications thereof
  • Sanguisorba officinalis sapogenin oral emulsion as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 oral emulsion of the present invention

[0031] Weigh the raw materials according to the following ratio:

[0032] Sanguigenin 1mg, soybean oil 100mg, egg yolk lecithin 20mg, glycerin 2mg.

[0033] The preparation method is as follows:

[0034] Take Sanguigenin, soybean oil, and egg yolk lecithin, mix them, dissolve them in ethanol, remove the ethanol by rotary evaporation under reduced pressure, add glycerin and appropriate amount of water under high-speed stirring, so that the concentration of Sanguigenin in the emulsion is 0.3mg / mL, 10000rpm Under high-speed shearing for 5 minutes, high-pressure homogenization under 800 bar pressure for 4 times, and high-pressure sterilization to obtain the oral emulsion of the present invention.

Embodiment 2

[0035] Embodiment 2 Preparation of oral emulsion of the present invention

[0036] Weigh the raw materials according to the following ratio:

[0037] Burnet genin 1mg, medium chain triglyceride 300mg, egg yolk lecithin 20mg, glycerin 3mg.

[0038] The preparation method is as follows:

[0039] Take Sanguigenin, medium-chain triglycerides, and egg yolk lecithin, mix them, dissolve them in ethanol, remove the ethanol by rotary evaporation under reduced pressure, add glycerin and appropriate amount of water under high-speed stirring, so that the concentration of Sanguigenin in the emulsion is 0.3mg / mL, high-speed shearing at 10000rpm for 5min, high-pressure homogenization at 800bar pressure for 4 times, and autoclaving to obtain the oral emulsion of the present invention.

Embodiment 3

[0040] Embodiment 3 Preparation of oral emulsion of the present invention

[0041] Weigh the raw materials according to the following ratio:

[0042] Sanguigenin 2mg, fish oil 300mg, egg yolk lecithin 20mg, glycerin 5mg.

[0043] The preparation method is as follows:

[0044] Take Sanguigenin, fish oil, and egg yolk lecithin, mix them, dissolve them in ethanol, remove the ethanol by rotary evaporation under reduced pressure, add glycerin and appropriate amount of water under high-speed stirring, so that the concentration of Sanguigenin in the emulsion is 0.3mg / mL, at 10000rpm High-speed shearing for 5 minutes, high-pressure homogenization under 800 bar pressure for 4 times, and high-pressure sterilization to obtain the oral emulsion of the present invention.

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Abstract

The invention provides sanguisorba officinalis sapogenin oral emulsion. The sanguisorba officinalis sapogenin oral emulsion is a prepared from the following raw materials in parts by weight: 0.5-10 parts of sanguisorba officinalis sapogenin, 1-300 parts of oral oil, 0.5-30 parts of an emulsifying agent, and 0.001-5 parts of a stabilizer. The invention further provides a preparation method and applications of the oral emulsion. The sanguisorba officinalis sapogenin oral emulsion prepared by adopting the method provided by the invention has the obvious effect in treating and / or preventing myelosuppression.

Description

technical field [0001] The invention relates to an oral emulsion of eucalyptus saponin and its preparation method and application, belonging to the field of medicines. Background technique [0002] Myelosuppression is a clinically common hematopoietic system disease, which can occur in radiotherapy and / or chemotherapy of tumor diseases of various systems, radiation injury caused by ionizing radiation, viral hepatitis, parvovirus infection or drugs (chloramphenicol , benzene, sulfonamides, antiepileptics, sedatives, antithyroid drugs, antidiabetics, antimalarials, sleeping pills) and other factors. Bone marrow suppression can cause damage to the bone marrow microenvironment, hematopoietic stem cells, hematopoietic growth factors, etc., and the first, second or third lineage of granulocytes, erythrocytes, and megakaryocytes are inhibited. Agranulocytosis can cause serious infection; red blood cell decrease can cause severe anemia; platelet decrease can cause severe bleeding a...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/56A61K47/44A61K47/10A61P7/00A61P35/00A61P9/06
CPCA61K9/107A61K9/0053A61K31/56A61K47/10A61K47/44
Inventor 杨世林
Owner SICHUAN YINGLU WEITE PHARMA TECH CO LTD
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