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A method for testing the pore size distribution of hemodialysis membranes

A technology of pore size distribution and hemodialysis, applied in the direction of permeability/surface area analysis, suspension and porous material analysis, measuring device, etc., to achieve the effect of small data fluctuation, practical and convenient performance evaluation method, and high precision

Active Publication Date: 2021-03-12
WEIHAI WEIGAO BLOOD PURIFICATION PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention provides a method for testing the pore size distribution of hemodialysis membranes, aiming at solving the shortcomings of the above-mentioned pore size distribution testing method

Method used

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  • A method for testing the pore size distribution of hemodialysis membranes
  • A method for testing the pore size distribution of hemodialysis membranes
  • A method for testing the pore size distribution of hemodialysis membranes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Take a certain brand polysulfone Qualcomm hemodialyzer on the market. A variety of dextran was used as the test solute, the weight-average molecular weights of which were 1kDa, 10kDa, 50kDa and 100kDa, respectively, dissolved in ultrapure water as the simulated solution. The simulated liquid was filtered through a polysulfone high-pass hemodialyzer, and the filtrate was obtained after 30 minutes of stability after the experiment was run. The operating pressure was 10-20 kPa. The simulated solution and filtrate were tested for molecular weight distribution by gel permeation chromatography, and the dextran concentration corresponding to each molecular weight in the two solutions was obtained. Using relational formulas 1 and 2, the retention performance curves of the dialysis membrane for dextran of various molecular weights were obtained. The interception performance data is nonlinearly fitted to relational expression 4 by SPSS software, and the fitting adopts the Levinb...

Embodiment 2

[0073] Take a certain brand of polysulfone low-pass hemodialyzer on the market. A variety of polyethylene glycols were used as test solutes, with weight average molecular weights of 1kDa, 6kDa, 12kDa and 35kDa, dissolved in ultrapure water as a simulated solution. The simulated liquid was filtered through a polysulfone low-pass dialyzer, and the filtrate was obtained after 30 minutes of stability after the experiment was run. The operating pressure was 10-20 kPa. The simulated liquid and the filtrate were tested for molecular weight distribution by gel permeation chromatography, and the polyethylene glycol concentration corresponding to each molecular weight in the two solutions was obtained. Using relational formulas 1 and 2, the cut-off performance curves of the dialysis membrane for polyethylene glycols of various molecular weights were obtained. Use 1stopt software to nonlinearly fit the interception performance data to relational expression 4, and use simple surface clim...

Embodiment 3

[0075] Take a certain brand of polysulfone hemodialysis filter on the market. A variety of polysucrose was used as the test solute, the weight-average molecular weights of which were 1kDa, 20kDa, 50kDa and 100kDa, respectively, dissolved in ultrapure water as the simulated solution. The simulated liquid was filtered through a polysulfone hemodialysis filter, and the filtrate was obtained after 30 minutes of stability after the experiment was run. The operating pressure was 10-20 kPa. The simulated liquid and the filtrate were tested for molecular weight distribution by gel permeation chromatography, and the polysucrose concentration corresponding to each molecular weight in the two solutions was obtained. Using relational formulas 1 and 2, the retention performance curves of the dialysis membrane for polysucrose of various molecular weights were obtained. The interception performance data is nonlinearly fitted to relational expression 4 by 1stopt software, and the fitting ado...

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Abstract

The invention discloses a test method of the aperture distribution of a hemodialysis membrane. The method comprises the following steps: dissolving one or more solutes in ultrapure water to form a simulation solution, and filtering the simulation solution through the hemodialysis membrane; testing the concentration of corresponding solute molecular weight in the simulation solution and the concentration of corresponding solute molecular weight in a filtrate; calculating a curve of the molecular diameter of the corresponding solute molecular weight and the interception rate of the hemodialysis membrane; establishing the aperture distribution function and the accumulated distribution function of the hemodialysis membrane; and carrying out nonlinear fitting on the accumulated distribution function on practically measured interception rate curve data through least squares fitting analysis software, determining the aperture distribution parameter, and substituting the aperture distribution parameter into the aperture distribution function to obtain the aperture distribution of the hemodialysis membrane. The method is used to rapidly detect the aperture distribution of the hemodialysis membrane., and has the advantages of high accuracy of measured data, simplicity and high practicality.

Description

technical field [0001] The invention relates to the technical field of characterization of hemodialysis membranes, in particular to a method for testing the pore size distribution of hemodialysis membranes. Background technique [0002] Hemodialyzer, commonly known as artificial kidney, is a conventional hemodialysis device for blood purification and is mainly used to treat symptoms such as chronic renal failure, acute renal failure and drug poisoning. The hemodialyzer mainly uses the principles of diffusion, convection, and adsorption to expel toxic small and medium molecular substances in the blood, and retain beneficial macromolecular blood components such as red blood cells and albumin, so as to achieve the purpose of purifying the blood. [0003] During dialysis, the selective separation performance of the dialyzer is mainly affected by the pore size and pore size distribution of the hemodialysis membrane. The membrane pore size refers to the diameter of the narrowest ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/08
CPCG01N15/088
Inventor 牟倡骏张洁敏徐天成代朋
Owner WEIHAI WEIGAO BLOOD PURIFICATION PROD
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