Biocompatible bone graft and preparation method thereof

Abstract

The invention provides a biocompatible bone graft. The main components of the stent include silk fibroin, polyvinyl alcohol, calcium salt, cartilage cytoskeleton-removed component of amphibian and an osteogenic induction factor; and the mechanical strength and degradation speed of the bone graft can be controlled by changing the proportion of the components. The biocompatible bone graft is of a three-dimensional solid shape and has good mechanical properties; and dense holes in the surface promote the adhesion and regeneration of cartilage cells. In the preparation process of the biocompatible bone graft, heating is not needed, no chemical or enzyme crosslinking agent is used, and the activity of each component is maintained. The biocompatible bone graft gives play to the collaborative advantage of each component and is applied to the substitute graft of bone tissue defect.

Description

technical field [0001] The invention relates to the technical field of medical bone graft engineering, in particular to a biocompatible bone graft with regeneration performance and ideal mechanical strength and a preparation method thereof. Background technique [0002] The self-repair ability of bone is extremely limited, and the construction of engineered bone with tissue engineering technology provides a promising method for repairing bone defects. The research content of bone transplantation involves many aspects of materials, preparations, and transplantation medicine. The key to success is to construct an ideal biocompatible bone graft with regenerative properties and ideal mechanical strength. [0003] At present, the scaffold materials used in bone transplantation engineering include natural materials and synthetic materials. The synthetic materials mainly include polyglycolide, polylactide and their copolymers. The disadvantage of artificial synthetic materials is ...

AI Technical Summary

Problems solved by technology

In recent years, with the rise of research on tissue-engineered organs and cell scaffolds and the development of various biotechnologies, silk fibroin has been used more and more widely, and has been successfully used in various medical materials such as surgical sutures. However, silk fibroin Does not have the ability to promote cartilage regeneration

In addition, in vitro cell culture experiments found that in the culture dish coated with silk fibroin, the cells were not easy to adhere and grew slowly.

Therefore, although silk fibroin has good mechanical properties such as elastic strength and wear resistance, it lacks the ability to promote cell adhesion and regeneration, so it is difficult to be used in bone grafts.

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