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Preparation method of nano meso-porous silicon composite hydrogel with controlled release function

A composite hydrogel and nano-mesoporous technology, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, inorganic non-active ingredients, etc., can solve the problem of reducing the drug release rate, and achieve good biocompatibility and biological Effects of degradability, clear pores and good biocompatibility

Inactive Publication Date: 2017-03-15
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the results of in vitro small molecule drug release experiments show that the nanocomposite hydrogel can slowly release the drug, and the drug release rate is significantly reduced compared with the pure hydrogel

Method used

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  • Preparation method of nano meso-porous silicon composite hydrogel with controlled release function
  • Preparation method of nano meso-porous silicon composite hydrogel with controlled release function
  • Preparation method of nano meso-porous silicon composite hydrogel with controlled release function

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Experimental program
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Effect test

Embodiment 1

[0028] A preparation method of nanometer mesoporous silicon composite hydrogel with controlled release function:

[0029] (1) Use sodium periodate to oxidize hyaluronic acid into formylated hyaluronic acid, obtain the oxidized solid after purification and freeze-drying, wherein the molar mass of sodium periodate and a structural unit in the hyaluronic acid molecular chain The ratio is 5:4;

[0030] (2) Dissolving the oxidized hyaluronic acid and carboxymethyl chitosan in step (1) respectively in phosphate buffered saline solution, the concentration of both solutions being 6 wt%. ;

[0031] (3) After the two solutions in step (2) are completely dissolved, respectively draw 0.5mL of the two polymer solutions and add them to the 24-well cell culture plate to quickly stir the two solutions evenly, and water can be found after standing for two minutes. The gel has transformed from a liquid to a solid state to form a pure hydrogel.

Embodiment 2

[0033] A preparation method of nanometer mesoporous silicon composite hydrogel with controlled release function:

[0034] (1) Using sodium periodate to oxidize hyaluronic acid into formylated hyaluronic acid, after purification and freeze-drying, the oxidized solid is obtained, wherein the molar mass ratio of sodium periodate to a unit of hyaluronic acid is 5: 4;

[0035] (2) the oxidized hyaluronic acid and carboxymethyl chitosan in the step (1) are dissolved in phosphate buffered saline respectively, and the concentration of both solutions is 6wt%;

[0036] (3) Prepare mesoporous silicon nanoparticles, disperse them in deionized water at a concentration of 0.1%, and add the model drug FITC (accounting for one-tenth of the mass of nanoparticles) to the solution after the mesoporous silicon nanoparticles are uniformly dispersed Ultrasonic dispersion in medium, and stirring in the dark for 24 hours, so that FITC is loaded into the pores of mesoporous silicon nanoparticles, and...

Embodiment 3

[0039] A preparation method of nanometer mesoporous silicon composite hydrogel with controlled release function:

[0040] (1) Using sodium periodate to oxidize hyaluronic acid into formylated hyaluronic acid, after purification and freeze-drying, the oxidized solid is obtained, wherein the molar mass ratio of sodium periodate to a unit of hyaluronic acid is 5: 4;

[0041] (2) the oxidized hyaluronic acid and carboxymethyl chitosan in the step (1) are dissolved in phosphate buffered saline respectively, and the concentration of both solutions is 6wt%;

[0042](3) Prepare mesoporous silicon nanoparticles, disperse them in deionized water at a concentration of 0.1%, and add the model drug FITC (accounting for one-tenth of the mass of nanoparticles) to the solution after the mesoporous silicon nanoparticles are uniformly dispersed Ultrasonic dispersion in medium, and stirring in the dark for 24 hours, so that FITC is loaded into the pores of mesoporous silicon nanoparticles, and ...

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Abstract

The invention discloses a preparation method of nano meso-porous silicon composite hydrogel with a controlled release function. The preparation method includes the steps that micromolecular medicine is loaded in meso-porous silicon nano-particles; an oxidized hyaluronic acid and carboxymethyl chitosan solution is prepared, and the medicine-carrying nano-particles are added into the hyaluronic acid solution to be ultrasonically treated and then stirred to be uniform; a medicine-carrying nano composite hydrogel carrier is prepared. The prepared nano composite hydrogel has good mechanical performance, biocompatibility, biodegradability and medicine slow release effects, and has potential of being applied to the fields of tissue engineering and biological medicine treatment. In addition, the preparation method of the nano composite hydrogel is simple, cost is low, and large-scale production can be achieved.

Description

technical field [0001] The invention belongs to the field of preparation of composite hydrogel materials, in particular to a preparation method of nano mesoporous silicon composite hydrogel with controlled release function. Background technique [0002] Growth factor is one of the important factors in tissue engineering construction, and the release behavior of growth factor at the damaged site affects the regeneration behavior of damaged tissue. A reasonable concentration of growth factors can promote cell adhesion and proliferation on the scaffold and induce differentiation, while excessive growth factors accumulated around the damaged tissue will produce low toxicity and carcinogenicity. Among them, small molecule drug growth factors are prone to burst release in the body fluid environment, resulting in a large amount of growth factors gathering in the damaged part at the initial stage of stent implantation, resulting in low toxicity or growth factors spreading to the who...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/36A61K9/06A61L27/54A61L27/52
CPCA61K9/0002A61K9/06A61K47/02A61K47/36A61L27/52A61L27/54A61L2300/602
Inventor 何创龙张骞骞陈良秦明冯炜周小军
Owner DONGHUA UNIV
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