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A kind of method of leaching saponins and polysaccharides

A technology of leaching and saponin, which is used in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of large environmental pollution, low selectivity, and volatile solvents.

Active Publication Date: 2020-10-09
内蒙古宏魁生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction and separation of biological substances often use two-phase extraction method. Although this method has the advantages of mild conditions, easy scale-up and continuous operation, due to the use of a two-phase extraction system composed of water-miscible organic solvents and salts, There are disadvantages of volatile solvents, large environmental pollution, and low selectivity

Method used

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  • A kind of method of leaching saponins and polysaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Weigh 1 part by weight of Cynomorium tablets, add cold water, soak for a period of time under ultrasonic waves or microwaves (see Table 1 for details), heat the system to a certain temperature, and keep for a period of time under ultrasonic waves or microwaves (see Table 1 for details) First hot water extraction), centrifugal separation to obtain solid I and extract I; add a certain amount of water to solid I, heat to a certain temperature and keep it for a period of time (second hot water extraction), centrifugal separation to obtain solid II and extract II; add a certain amount of water to solid II, heat to a certain temperature and keep it for a period of time (the third hot water extraction), and centrifuge to obtain solid III and extract III. Combine the extract I, extract II and extract III, place them in an environment with a temperature of 2-8°C and let them stand for more than 24 hours, filter them with a cloth bag to remove the precipitate, then add them to the...

Embodiment 2

[0089] Weigh 1 part by weight of Cynomorium tablets, add cold water and soak in ultrasonic waves (22kHz, 40W / kg) at 10°C for 1h, then heat to 85°C and start continuous countercurrent leaching in a Kennedy type extractor, solid phase and liquid phase The mass ratio of phase addition was 1:5, and the obtained sample was denoted as G8.

Embodiment 3

[0091] The total saponins and total saponins and polysaccharide contents in samples G1-G7 were measured, and the results are shown in Table 3.

[0092] table 3

[0093] Sample serial number Total saponins (wt%) Polysaccharide (wt%) G1 0.252 45.28 G2 0.237 38.59 G3 0.228 36.27 G4 0.241 38.31 G5 0.234 35.45 G6 0.209 31.15 G7 0.198 27.57

[0094] As can be seen from the data in Table 3, in the saponin and polysaccharide crude products extracted according to the method described in the present application, the total saponin and polysaccharide content is high, and the method has good selectivity to saponin and polysaccharide.

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Abstract

The invention discloses a method for leaching saponin and polysaccharide. The method is characterized by comprising the following steps: pre-processing sliced herba cynomorii in water at 0-30 DEG C, and leaching the pre-processed sliced herba cynomorii by virtue of water at 80-100 DEG C. The method has the advantages of being simple and easy to operate, high in extracting and separating speeds, free from the use of a volatile organic solvent, low in environmental pollution and high in selectivity on the saponin and polysaccharide.

Description

technical field [0001] The application relates to a method for extracting saponins and polysaccharides from Cynomorium cynomorium, which belongs to the field of separation and extraction of effective components of natural products. Background technique [0002] Cynomorium was first recorded in "Materia Medica Yanyi Supplement", and "Compendium of Materia Medica" also recorded that Cynomorium is also known as elixir, rust iron rod, ground hair ball, yellow ancient wolf, sheep lock and pull, and belongs to Cynomorium genus Cynomorium. The dry fleshy stem of Cynomorium cynomorium grows in dry and sandy areas, and mostly parasitizes on the roots of Nitraria terrestris. It is mainly distributed in Inner Mongolia, Ningxia, Xinjiang, Gansu, Qinghai and other northwest regions. Cynomorium is sweet in taste and warm in nature. It has the effects of nourishing kidney yang, nourishing essence and blood, moistening intestines and laxative. It is a commonly used medicine in traditional C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K36/185A61P1/10A61P31/04A61P31/10A61P29/00A61P35/00A61K125/00A61K31/715
CPCA61K31/715A61K36/185A61K2236/331A61K2236/39A61K2236/53C08B37/0003A61K2300/00
Inventor 张金玉裴静刘涌王树国
Owner 内蒙古宏魁生物药业有限公司
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