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Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation

A technology of vitamins and calcium carbonate, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, etc., can solve problems affecting calcium absorption, etc.

Active Publication Date: 2017-02-22
北京远方通达医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method effectively solves the stability problem of vitamin D3, the unsaturated bond in the vitamin D3 molecule has been inserted into the three-dimensional structure of β-cyclodextrin to form an inclusion compound, which limits the contact between vitamin D3 and calcium. , affecting the body's absorption of calcium

Method used

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  • Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation
  • Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation
  • Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Embodiment 1, the preparation of calcium carbonate / vitamin D3 chewable tablet

[0122] prescription:

[0123] 1) Vitamin D3 Coating Powder

[0124]

[0125] 2) Calcium Carbonate / Vitamin D3 Chewable Tablets

[0126]

[0127]

[0128] Preparation Process:

[0129] 1) Preparation of vitamin D3 coating powder

[0130] a) dissolving the prescribed amount of vitamin D3 in an appropriate amount of ethanol to obtain a vitamin D3 solution;

[0131] b) dissolving the Opadry powder of the prescribed amount in an appropriate amount of purified water to obtain a coating solution;

[0132] c) Place the prescribed amount of sorbitol in a fluidized bed, then spray the vitamin D3 solution on the surface of the sorbitol, then spray coating with the coating solution, and dry after the coating solution is sprayed to obtain the vitamin D3 coating Powder; wherein the material temperature is set to 38°C during coating, and the speed is set to 50rpm when spraying vitamin D3 solut...

Embodiment 2

[0140] Embodiment 2, the preparation of calcium carbonate / vitamin D3 chewable tablet

[0141] prescription:

[0142] 1) Vitamin D3 Coating Powder

[0143]

[0144] 2) Calcium Carbonate / Vitamin D3 Chewable Tablets

[0145]

[0146]

[0147] Preparation Process:

[0148] 1) Preparation of vitamin D3 coating powder

[0149] a) dissolving the prescribed amount of vitamin D3 in an appropriate amount of ethanol to obtain a vitamin D3 solution;

[0150] b) dissolving the Opadry powder of the prescribed amount in an appropriate amount of purified water to obtain a coating solution;

[0151] c) Mix the prescribed amount of mannitol and sorbitol and place it in a fluidized bed as a base material, then spray the vitamin D3 solution on the surface of the base material, and then spray coat with the coating solution, and wait until the coating solution is sprayed Dry to obtain vitamin D3 coating powder.

[0152] 2) Preparation of adhesive

[0153] With embodiment 1.

[0154...

Embodiment 3

[0156] Embodiment 3, the preparation of calcium carbonate / vitamin D3 chewable tablet

[0157] prescription:

[0158] 1) Vitamin D3 Coating Powder

[0159]

[0160] 2) Calcium Carbonate / Vitamin D3 Chewable Tablets

[0161]

[0162]

[0163] Preparation Process:

[0164] 1) Preparation of vitamin D3 coating powder

[0165] a) dissolving the prescribed amount of vitamin D3 in an appropriate amount of ethanol to obtain a vitamin D3 solution;

[0166] b) dissolving the Opadry powder of the prescribed amount in an appropriate amount of purified water to obtain a coating solution;

[0167] c) Place the prescribed amount of sorbitol in a fluidized bed, then spray the vitamin D3 solution on the surface of the sorbitol, then spray coating with the coating solution, and dry after the coating solution is sprayed to obtain the vitamin D3 coating Powder; wherein the material temperature is set to 42°C during coating, and the speed is set to 40rpm when spraying vitamin D3 solut...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a preparation containing vitamin D3 and calcium carbonate and a preparation method for the preparation. The preparation containing vitamin D3 and calcium carbonate comprises calcium carbonate, vitamin D3 and pharmaceutically acceptable auxiliary materials, wherein the vitamin D3 is vitamin D3 coating powder obtained by coating vitamin D3 with opadry. The vitamin D3 coating powder in the preparation containing vitamin D3 and calcium carbonate has relatively good stability, and is relatively high in uniformity of content of vitamin D3. Meanwhile, the preparation containing vitamin D3 and calcium carbonate provided by the invention can effectively promote absorption, on calcium, of a human body.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation containing vitamin D3 and calcium carbonate and a preparation method thereof. Background technique [0002] Calcium carbonate is one of the traditional calcium supplements in my country. It has the advantages of high calcium content and good calcium supplement effect. The calcium ions released in the human body after oral administration can participate in the formation of bones and the reconstruction of bone tissue after fractures, as well as muscle contraction and nerve function. Transmission, coagulation mechanism and reduce the permeability of capillaries, etc. Vitamin D3 is a fat-soluble vitamin that can improve the body's absorption of calcium and phosphorus, saturate the levels of plasma calcium and phosphorus, promote growth and bone calcification, and promote healthy teeth. It can be taken with calcium sources at the same time....

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K47/38A61P3/02A61K31/593
Inventor 石峰方益胜
Owner 北京远方通达医药技术有限公司
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