Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A polymethoxylated flavone, composition and pharmaceutical preparation thereof for preventing or treating non-alcoholic fatty liver

A technology of polymethoxyflavone and heptamethoxyflavone, applied in the field of medicine, can solve problems such as unsatisfactory effects

Active Publication Date: 2019-04-23
CHINA PHARM UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for the treatment of NAFLD in modern medicine. It mainly focuses on eliminating the etiology and incentives, and treating the primary underlying disease, so as to prevent the development of chronic liver disease and prevent and treat steatohepatitis. At the end stage, liver transplantation is used for treatment, but the effect of treatment Unsatisfactory, so the development of new drugs to effectively treat NAFLD has important clinical significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A polymethoxylated flavone, composition and pharmaceutical preparation thereof for preventing or treating non-alcoholic fatty liver
  • A polymethoxylated flavone, composition and pharmaceutical preparation thereof for preventing or treating non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0017] experimental method:

[0018] 1. Establishment of animal models

[0019] Take 60 C57BL / 6 male mice, weighing 18-20 g, aged 6 weeks. After one week of adaptation, the mice were randomly divided into: normal diet group (Normal chow diet, NCD), high fat diet group (High fat diet, HFD), lovastatin group (Lovastatin, LOV), 3,5,6,7, 8,3',4'-heptamethoxyflavone low-dose group (HMF-L) and 3,5,6,7,8,3',4'-heptamethoxyflavone high-dose group (HMF-H ), and the other groups except the normal diet group adopted a high-fat diet. HFD feed formula is: 1.25% cholesterol, 20% lard, 5% sucrose, 0.5% cholic acid, vitamins adjusted to normal levels.

[0020] 2. Dosage and administration method: In the HFD induction experiment, mice were administered by intragastric administration. Modeling began to administer drugs, and NCD and HFD w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses polymethoxylated flavonoids, a composition, and application of preparations thereof to prevent or treat non-alcoholic fatty liver diseases. The medicine for preventing or treating the non-alcoholic fatty liver diseases comprises the active ingredients of polymethoxylated flavonoids and pharmaceutically acceptable carriers or excipient, wherein the polymethoxylated flavonoids is 3,5,6,7,8,3',4'-heptemthoxyflavone; the medicine is prepared into a pharmaceutically acceptable dosage form. After giving HMF (hydroxymethyl furfural), the liver structure is greatly improved; the liver fat accumulation caused by high fat diet is reduced; the HMF high-concentration liver lipid droplets approach to the normal level; the results show that the 3,5,6,7,8,3',4'-heptemthoxyflavone can effectively improve the liver lipid accumulation, achieves the effect of preventing or treating the non-alcoholic fatty liver diseases, and has the dose-effect difference.

Description

technical field [0001] The invention belongs to the field of medicine and relates to new applications of natural products, in particular to polymethoxylated flavones, compositions and pharmaceutical preparations for preventing or treating non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors. It is related to the global prevalence of metabolic syndrome. In recent years, the incidence of NAFLD has shown a clear upward trend. It has become the number one cause of chronic liver disease and abnormal liver function in developed countries. The prevalence of NAFLD in ordinary adults is 17%. ~33%. At present, there is no specific drug for the treatment of NAFLD in modern medicine. It mainly focuses on eliminating the etiology and incentives, and treating the primary underlying disease,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/352A61P1/16
CPCA61K31/352A61K31/7048A61K2300/00
Inventor 刘鄂湖肖娉婷谢志深
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com