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A traditional Chinese medicine composition for improving sleep quality and its preparation method and application

A technology for improving sleep quality and composition, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of weak effect of soothing the liver and strengthening the spleen, and achieve the advantages of increasing the rate of falling asleep, easily obtaining materials, and prolonging the duration of sleep. Effect

Active Publication Date: 2020-08-14
湖南协和健康科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically commonly used Chinese patent medicines include Tianwang Buxin Dan, Baizi Yangxin Pills, Anshen Buxin Pills (capsules, granules), Yangxue Anshen Tablets, Zaoren Anshen Granules, Qiye Shen'an Tablets, Mian'anning Oral Liquid, Schisandra Syrup, Anshen Bunao liquid, etc. The above-mentioned drugs tend to nourish the liver and nourish the liver, nourish the heart and calm the nerves, but the effect of soothing the liver and strengthening the spleen is relatively weak

Method used

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  • A traditional Chinese medicine composition for improving sleep quality and its preparation method and application
  • A traditional Chinese medicine composition for improving sleep quality and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Chinese medicine composition (decoction)

[0024] (1) Take 40g of bergamot, 30g of lily, 25g of jujube seed, 15g of poria cocos, 10g of lotus seed, and mash the jujube kernel;

[0025] (2) Add water with 8 times the weight of medicinal materials, and decoct twice, each time for 1 hour;

[0026] (3) Combine the decoction, filter and concentrate to 120ml to obtain a decoction of 1g / ml.

Embodiment 2

[0027] The preparation of embodiment 2 Chinese medicine composition (granule)

[0028] (1) Take 40g of bergamot, 30g of lily, 25g of jujube seed, 15g of poria cocos, 10g of lotus seed, and mash the jujube kernel;

[0029] (2) Add water with 8 times the weight of medicinal materials, and decoct twice, each time for 1 hour;

[0030] (3) merge decoction, filter;

[0031] (4) Concentrate the filtered decoction at 60°C to a clear paste with a relative density of 1.38, and dry it in an oven at 75°C to form a dry paste;

[0032] (5) Crush the dry paste into fine powder, add maltodextrin to 17g, add water to make granules, dry at 60°C and sieve the whole granule, pass through a 14-mesh sieve to remove large particles, and pass through a 60-mesh sieve to remove fine powder , after obtaining the granules, pack them into 8.5g / bag.

Embodiment 3

[0033] Example 3 Validation of the effect of traditional Chinese medicine composition on improving sleep quality

[0034] 1. Materials and methods

[0035] 1.1 Test drugs

[0036] Get the obtained decoction of embodiment 1, continue to concentrate, be mixed with high, middle and low dosage groups successively, the concentration of high dosage group is 2.4g / ml, the concentration of middle dosage group is 1.2g / ml, the concentration of low dosage group is 0.6g / ml. ml.

[0037] 1.2 Experimental animals

[0038] Male SPF grade Kunming mice, weighing 20±2g, provided by the Experimental Animal Center of Southern Medical University, certificate number SYXK (Guangdong) 2011-0074, the animals were fed in the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, and the temperature of the feeding environment in the experiment room The temperature is 24-26°C, the humidity is 50%-60%, light and dark are alternated for 12 hours, and water and food are free t...

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Abstract

The invention relates to a traditional Chinese medicinal composition for improving the sleep quality and a preparation of the traditional Chinese medicinal composition. The formula of the traditional Chinese medicinal composition is prepared from the following components: 30 to 50 parts of fructus citri sarcodactyli, 20 to 40 parts of lily bulb, 10 to 30 parts of semen ziziphi spinosae, 5 to 20 parts of poria cocos and 5 to 15 parts of semen nelumbinis. According to the traditional Chinese medicinal composition disclosed by the invention, the components are reasonably matched according to a traditional Chinese theoretical formula. Pharmacology experiment results show that the traditional Chinese medicinal composition has a function of improving the sleep quality; the traditional Chinese medicinal formula and an extraction method are simple; crude drugs are easily obtained; the traditional Chinese medicinal composition is low in cost and easy to produce; the quality is easy to control.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for improving sleep quality and an application thereof. Background technique [0002] With the accelerated pace of modern life, intensified competition, and increased work or study pressure, "staying up late" has become a living habit of all age groups, and the incidence of insomnia has gradually increased, which has caused great harm to people's physical and mental health, quality of life and work efficiency. big negative impact. The epidemiological study of insomnia in 10 countries in the world in 2002 showed that 12.1% of the general population suffered from insomnia (DSM-IV standard), while 45.4% of people in my country had experienced insomnia to varying degrees in the past month. [0003] About 1 / 3 of a person's life is spent in sleep. Sleep is an important part of the body's recovery, integration and memory consolidat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8967A61K9/16A61K9/00A61P25/20A61K9/20A61K9/48
CPCA61K9/0095A61K9/1652A61K9/2004A61K9/4825A61K36/076A61K36/62A61K36/725A61K36/752A61K36/8967A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 谢炜
Owner 湖南协和健康科技研究院有限公司
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